PMID- 34081781
OWN - NLM
STAT- MEDLINE
DCOM- 20220112
LR  - 20220112
IS  - 1423-0410 (Electronic)
IS  - 0042-9007 (Linking)
VI  - 117
IP  - 1
DP  - 2022 Jan
TI  - Passive immune basophil activation test for the identification of allergic 
      episodes from various adverse events elicited by haematopoietic cell 
      transplantation: A pilot study.
PG  - 119-127
LID - 10.1111/vox.13131 [doi]
AB  - BACKGROUND AND OBJECTIVES: Haematopoietic cell transplantation (HCT) therapy 
      tends to be associated with various complications including engraftment failure, 
      regimen-related toxicities, and infectious diseases. In addition, HC infusion 
      itself occasionally elicits adverse events (AEs), one of the most common AEs is 
      an allergic reaction. As appropriate laboratory tests have not yet been 
      established to distinguish allergy-mediated AEs from other complications, 
      clinical responses for HCT-related AEs can only be nonspecific. In this pilot 
      study, using passive immune basophil activation test (pi-BAT), we attempted to 
      distinguish an HC infusion-induced allergic reaction from various HCT-related 
      AEs. MATERIALS AND METHODS: Using pi-BAT, we examined 34 patients who underwent 
      HCT, that is, 11 with AEs and 23 without AEs as controls. RESULTS: Two of the 
      eleven AE cases were pi-BAT positive and, the rest of nine AE cases were 
      negative, while all non-AE cases were negative. Both of the two positive cases 
      showed erythema, tachycardia, plus cough. Because erythema is one of the 
      representative symptom of allergy, those cases could be classified as allergic 
      reaction cases or anaphylaxis cases if tachycardia and cough were concomitant 
      symptoms of erythema. Among the nine AEs with pi-BAT negative result, four cases 
      showed urticaria, four showed vomiting plus diarrhoea, and one showed cough. 
      Urticaria case was strongly suspected of allergy, however, the AE cases were 
      pi-BAT negative. CONCLUSION: The pi-BAT may be useful as an auxiliary diagnostic 
      tool to confirm the possible involvement of HC infusion in HCT-related AEs and 
      identify an immunologic mechanism for HCT-related hypersensitivity reactions.
CI  - (c) 2021 International Society of Blood Transfusion.
FAU - Yasui, Kazuta
AU  - Yasui K
AUID- ORCID: 0000-0001-8714-2949
AD  - Research and Development, Japanese Red Cross Kinki Block Blood Center, Ibaraki, 
      Japan.
FAU - Enami, Terukazu
AU  - Enami T
AD  - Division of Hematology and Stem Cell Transplantation, Shizuoka Cancer Center, 
      Nagaizumi-chou, Japan.
FAU - Okamura-Shiki, Ikue
AU  - Okamura-Shiki I
AD  - Division of Hematology and Stem Cell Transplantation, Shizuoka Cancer Center, 
      Nagaizumi-chou, Japan.
FAU - Ueda, Tomoaki
AU  - Ueda T
AD  - Department of Hematology and Oncology, Osaka University Graduate School of 
      Medicine, Suita, Japan.
FAU - Fukushima, Kentaro
AU  - Fukushima K
AD  - Department of Hematology and Oncology, Osaka University Graduate School of 
      Medicine, Suita, Japan.
FAU - Matsuyama, Nobuki
AU  - Matsuyama N
AD  - Research and Development, Japanese Red Cross Kinki Block Blood Center, Ibaraki, 
      Japan.
FAU - Kimura, Takafumi
AU  - Kimura T
AD  - Research and Development, Japanese Red Cross Kinki Block Blood Center, Ibaraki, 
      Japan.
FAU - Takanashi, Minoko
AU  - Takanashi M
AD  - Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.
FAU - Hosen, Naoki
AU  - Hosen N
AD  - Department of Hematology and Oncology, Osaka University Graduate School of 
      Medicine, Suita, Japan.
FAU - Ikeda, Takashi
AU  - Ikeda T
AD  - Division of Hematology and Stem Cell Transplantation, Shizuoka Cancer Center, 
      Nagaizumi-chou, Japan.
FAU - Takihara, Yoshihiro
AU  - Takihara Y
AD  - Research and Development, Japanese Red Cross Kinki Block Blood Center, Ibaraki, 
      Japan.
FAU - Hirayama, Fumiya
AU  - Hirayama F
AUID- ORCID: 0000-0001-6518-2085
AD  - Research and Development, Japanese Red Cross Kinki Block Blood Center, Ibaraki, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20210603
PL  - England
TA  - Vox Sang
JT  - Vox sanguinis
JID - 0413606
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - *Anaphylaxis
MH  - Basophil Degranulation Test
MH  - Basophils
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Immunoglobulin E
MH  - Pilot Projects
MH  - Skin Tests
OTO - NOTNLM
OT  - allergic-adverse events
OT  - haematopoietic cell transplantation-related adverse events
OT  - passive immune basophil activation test
EDAT- 2021/06/04 06:00
MHDA- 2022/01/13 06:00
CRDT- 2021/06/03 17:21
PHST- 2021/04/19 00:00 [revised]
PHST- 2021/01/31 00:00 [received]
PHST- 2021/04/29 00:00 [accepted]
PHST- 2021/06/04 06:00 [pubmed]
PHST- 2022/01/13 06:00 [medline]
PHST- 2021/06/03 17:21 [entrez]
AID - 10.1111/vox.13131 [doi]
PST - ppublish
SO  - Vox Sang. 2022 Jan;117(1):119-127. doi: 10.1111/vox.13131. Epub 2021 Jun 3.