PMID- 34082134
OWN - NLM
STAT- MEDLINE
DCOM- 20211029
LR  - 20211029
IS  - 1873-0329 (Electronic)
IS  - 1383-5769 (Linking)
VI  - 84
DP  - 2021 Oct
TI  - Opisthorchis viverrini antigens up-regulates the expression of CD80 and MHC class 
      II in JAWSII mouse dendritic cells and promotes IL-10 and TGF-beta secretions.
PG  - 102401
LID - S1383-5769(21)00119-7 [pii]
LID - 10.1016/j.parint.2021.102401 [doi]
AB  - Dendritic cells (DCs) are antigen-presenting cells (APC) involved in the 
      initiation of immune responses. Maturation of DCs is characterized by the high 
      expression of major histocompatibility complex (MHC) class II and co-stimulatory 
      clusters of differentiation (CD) 40, CD80, and CD86 molecules. Matured DCs are 
      required for T cell differentiation and proliferation. However, the response of 
      DCs to Opisthorchis viverrini antigens has not yet been understood. Therefore, 
      this study sought to determine the expression of surface molecules of JAWSII 
      mouse DCs stimulated by crude somatic (CS) and excretory-secretory (ES) antigens 
      of O. viverrini. ES antigen significantly induced only mRNA expression of CD80 
      and MHC class II in JAWSII mouse DCs, while CS antigen promoted up-regulation of 
      both mRNA and protein levels of CD80 and MHC class II, indicating relative 
      maturation of JAWII mouse DCs. Moreover, the secreted cytokines from the 
      co-cultures of O. viverrini antigens stimulated JAWSII DC with naive CD4(+) T 
      cells was determined. Significantly increased levels of immunosuppressive 
      cytokines interleukin (IL)-10 and transforming growth factor beta (TGF-beta) were 
      found. The up-regulation of these cytokines may indicate the response of 
      regulatory T cells (Treg) to CS antigen-stimulated JAWSII DC. These findings may 
      lead to a better understanding of the role that DCs play in O. viverrini 
      infection.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Jittimanee, Suphattra
AU  - Jittimanee S
AD  - Division of Pathobiology, Faculty of Veterinary Medicine, Khon Kaen University, 
      Khon Kaen, 40002, Thailand. Electronic address: suphattra@kku.ac.th.
FAU - Wongratanacheewin, Surasakdi
AU  - Wongratanacheewin S
AD  - Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 
      40002, Thailand. Electronic address: sura_wng@kku.ac.th.
FAU - Kaewraemruaen, Chamraj
AU  - Kaewraemruaen C
AD  - Department of Microbiology, Faculty of Liberal Arts and Science, Kasetsart 
      University, Kamphaeng Saen Campas, Nakhon Pathom, 73140, Thailand. Electronic 
      address: faascrka@ku.ac.th.
FAU - Jittimanee, Jutharat
AU  - Jittimanee J
AD  - College of Medicine and Public Health, Ubon Ratchathani University, Ubon 
      Ratchathani, 34190, Thailand. Electronic address: jutharat.j@ubu.ac.th.
LA  - eng
PT  - Journal Article
DEP - 20210531
PL  - Netherlands
TA  - Parasitol Int
JT  - Parasitology international
JID - 9708549
RN  - 0 (Antigens, Helminth)
RN  - 0 (B7-1 Antigen)
RN  - 0 (IL10 protein, mouse)
RN  - 0 (Transforming Growth Factor beta)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Animals
MH  - Antigens, Helminth/*metabolism
MH  - B7-1 Antigen/*metabolism
MH  - Dendritic Cells/metabolism
MH  - Gene Expression Regulation
MH  - *Genes, MHC Class II
MH  - Interleukin-10/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Opisthorchiasis/metabolism/parasitology
MH  - Opisthorchis/*physiology
MH  - Transforming Growth Factor beta/metabolism
MH  - Up-Regulation/*genetics
OTO - NOTNLM
OT  - CD80
OT  - IL-10
OT  - JAWSII dendritic cell
OT  - MHC class II
OT  - Opisthorchis viverrini
OT  - TGF-beta
EDAT- 2021/06/04 06:00
MHDA- 2021/10/30 06:00
CRDT- 2021/06/03 20:16
PHST- 2020/01/26 00:00 [received]
PHST- 2021/05/20 00:00 [revised]
PHST- 2021/05/27 00:00 [accepted]
PHST- 2021/06/04 06:00 [pubmed]
PHST- 2021/10/30 06:00 [medline]
PHST- 2021/06/03 20:16 [entrez]
AID - S1383-5769(21)00119-7 [pii]
AID - 10.1016/j.parint.2021.102401 [doi]
PST - ppublish
SO  - Parasitol Int. 2021 Oct;84:102401. doi: 10.1016/j.parint.2021.102401. Epub 2021 
      May 31.