PMID- 34084975
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210605
IS  - 2455-4626 (Electronic)
IS  - 2394-8108 (Print)
IS  - 2394-8108 (Linking)
VI  - 7
IP  - 1
DP  - 2021 Jan-Mar
TI  - Mitochondrial activity of human umbilical cord mesenchymal stem cells.
PG  - 33-36
LID - 10.4103/bc.bc_15_21 [doi]
AB  - Human umbilical cord mesenchymal stem cells (hUC-MSCs) serve as a potential 
      cell-based therapy for degenerative disease. They provide immunomodulatory and 
      anti-inflammatory properties, multipotent differentiation potential and are 
      harvested with no ethical concern. It is unknown whether MSCs collected from 
      different areas of the human umbilical cord elicit more favorable effects than 
      others. Three MSC populations were harvested from various regions of the human 
      umbilical cord: cord lining (CL-MSCs), perivascular region (PV-MSCs), and 
      Wharton's jelly (WJ-MSCs). Mesenchymal markers (CD90 and CD73) were expressed by 
      all three cell populations. Stemness marker (OCT4), endothelial cell adhesion 
      molecular marker (CD146), and monocyte-macrophage marker (CD14) were expressed by 
      WJ-MSCs, PV-MSCs, and CL-MSCs, respectively. Stroke presents with oxygen and 
      glucose deprivation and leads to dysfunctional mitochondria and consequently cell 
      death. Targeting the restoration of mitochondrial function in the stroke brain 
      through mitochondrial transfer may be effective in treating stroke. In vitro 
      exposure to ambient and OGD conditions resulted in CL-MSCs number decreasing the 
      least post-OGD/R exposure, and PV-MSCs exhibiting the greatest mitochondrial 
      activity. All three hUC-MSC populations presented similar metabolic activity and 
      survival in normal and pathologic environments. These characteristics indicate 
      hUC-MSCs potential as a potent therapeutic in regenerative medicine.
CI  - Copyright: (c) 2021 Brain Circulation.
FAU - Cozene, Blaise M
AU  - Cozene BM
AD  - School of Science and Engineering, Tulane University, New Orleans, LA, USA.
FAU - Russo, Eleonora
AU  - Russo E
AD  - Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of 
      Palermo, Palermo, Italy.
FAU - Anzalone, Rita
AU  - Anzalone R
AD  - Department of Surgical, Oncological and Stomatological Sciences, University of 
      Palermo, Palermo, Italy.
FAU - Rocca, Giampiero La
AU  - Rocca G
AD  - Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of 
      Palermo, Palermo, Italy.
FAU - Borlongan, Cesario V
AU  - Borlongan CV
AD  - Department of Cell and Molecular Biology, Morsani College of Medicine, University 
      of South Florida, Tampa, FL, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210330
PL  - India
TA  - Brain Circ
JT  - Brain circulation
JID - 101669876
PMC - PMC8057105
OTO - NOTNLM
OT  - Bioenergetics
OT  - Wharton's Jelly
OT  - ischemic diseases
OT  - mitochondria
OT  - stem cell therapy
OT  - stroke
OT  - umbilical cord mesenchymal stem cells
COIS- Prof. Cesario V. Borlongan is Associate Editor of Brain Circulation.
EDAT- 2021/06/05 06:00
MHDA- 2021/06/05 06:01
PMCR- 2021/03/30
CRDT- 2021/06/04 07:11
PHST- 2020/11/03 00:00 [received]
PHST- 2020/12/03 00:00 [revised]
PHST- 2020/12/15 00:00 [accepted]
PHST- 2021/06/04 07:11 [entrez]
PHST- 2021/06/05 06:00 [pubmed]
PHST- 2021/06/05 06:01 [medline]
PHST- 2021/03/30 00:00 [pmc-release]
AID - BC-7-33 [pii]
AID - 10.4103/bc.bc_15_21 [doi]
PST - epublish
SO  - Brain Circ. 2021 Mar 30;7(1):33-36. doi: 10.4103/bc.bc_15_21. eCollection 2021 
      Jan-Mar.