PMID- 34086179
OWN - NLM
STAT- MEDLINE
DCOM- 20220830
LR  - 20240424
IS  - 1573-6830 (Electronic)
IS  - 0272-4340 (Print)
IS  - 0272-4340 (Linking)
VI  - 42
IP  - 7
DP  - 2022 Oct
TI  - In Vivo Targeting of the Neurovascular Unit: Challenges and Advancements.
PG  - 2131-2146
LID - 10.1007/s10571-021-01113-3 [doi]
AB  - The blood-brain barrier (BBB) is essential for the homeostasis of the central 
      nervous system (CNS). Functions of the BBB are performed by the neurovascular 
      unit (NVU), which consists of endothelial cells, pericytes, astrocytes, 
      microglia, basement membrane, and neurons. NVU cells interact closely and 
      together are responsible for neurovascular coupling, BBB integrity, and 
      transendothelial fluid transport. Studies have shown that NVU dysfunction is 
      implicated in several acute and chronic neurological diseases, including 
      Alzheimer's disease, multiple sclerosis, and stroke. The mechanisms of NVU 
      disruption remain poorly understood, partially due to difficulties in selective 
      targeting of NVU cells. In this review, we discuss the relative merits of 
      available protein markers and drivers of the NVU along with recent advancements 
      that have been made in the field to increase efficiency and specificity of NVU 
      research.
CI  - (c) 2021. The Author(s).
FAU - Naranjo, Oandy
AU  - Naranjo O
AD  - Department of Biochemistry and Molecular Biology, University of Miami Miller 
      School of Medicine, Miami, FL, 33136, USA.
FAU - Osborne, Olivia
AU  - Osborne O
AD  - Department of Biochemistry and Molecular Biology, University of Miami Miller 
      School of Medicine, Miami, FL, 33136, USA.
FAU - Torices, Silvia
AU  - Torices S
AD  - Department of Biochemistry and Molecular Biology, University of Miami Miller 
      School of Medicine, Miami, FL, 33136, USA.
FAU - Toborek, Michal
AU  - Toborek M
AUID- ORCID: 0000-0003-4475-2119
AD  - Department of Biochemistry and Molecular Biology, University of Miami Miller 
      School of Medicine, Miami, FL, 33136, USA. mtoborek@med.miami.edu.
AD  - Institute of Physiotherapy and Health Sciences, The Jerzy Kukuczka Academy of 
      Physical Education, Katowice, Poland. mtoborek@med.miami.edu.
AD  - Department of Biochemistry and Molecular Biology, University of Miami School of 
      Medicine, Gautier Bldg., Room 528, 1011 NW 15th Street, Miami, FL, 33136, USA. 
      mtoborek@med.miami.edu.
LA  - eng
GR  - R01 MH128022/MH/NIMH NIH HHS/United States
GR  - R01 DA044579/DA/NIDA NIH HHS/United States
GR  - R01 DA039576/DA/NIDA NIH HHS/United States
GR  - R01 DA050528/DA/NIDA NIH HHS/United States
GR  - R01 DA040537/DA/NIDA NIH HHS/United States
GR  - R01 HL126559/HL/NHLBI NIH HHS/United States
GR  - F31 NS125905/NS/NINDS NIH HHS/United States
GR  - MH122235, MH072567/MH/NIMH NIH HHS/United States
GR  - 2019/35/B/NZ7/03155/Narodowe Centrum Nauki/
GR  - R21 MH122235/MH/NIMH NIH HHS/United States
GR  - DA044579, DA039576, DA040537, DA050528, and DA047157/DA/NIDA NIH HHS/United 
      States
GR  - R01 DA047157/DA/NIDA NIH HHS/United States
GR  - HL126559/HL/NHLBI NIH HHS/United States
GR  - R01 MH072567/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20210604
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
SB  - IM
MH  - Astrocytes
MH  - *Blood-Brain Barrier
MH  - Central Nervous System
MH  - *Endothelial Cells
MH  - Pericytes
PMC - PMC9056891
MID - NIHMS1798153
OTO - NOTNLM
OT  - Blood-brain barrier
OT  - Cre mouse models
OT  - Imaging
OT  - Neurovascular unit
OT  - Protein expression
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/06/05 06:00
MHDA- 2022/08/31 06:00
PMCR- 2021/06/04
CRDT- 2021/06/04 12:24
PHST- 2021/02/11 00:00 [received]
PHST- 2021/05/28 00:00 [accepted]
PHST- 2021/06/05 06:00 [pubmed]
PHST- 2022/08/31 06:00 [medline]
PHST- 2021/06/04 12:24 [entrez]
PHST- 2021/06/04 00:00 [pmc-release]
AID - 10.1007/s10571-021-01113-3 [pii]
AID - 1113 [pii]
AID - 10.1007/s10571-021-01113-3 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2022 Oct;42(7):2131-2146. doi: 10.1007/s10571-021-01113-3. 
      Epub 2021 Jun 4.