PMID- 34086260
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Linking)
VI  - 74
IP  - 2
DP  - 2021 Nov
TI  - The association between triglyceride-glucose index and the incidence of type 2 
      diabetes mellitus-a systematic review and dose-response meta-analysis of cohort 
      studies.
PG  - 254-262
LID - 10.1007/s12020-021-02780-4 [doi]
AB  - ABSTARCT: AIMS: We aimed to assess the dose-response relationship between 
      triglyceride-glucose (TyG) index and the incidence of type 2 diabetes mellitus 
      (T2DM). METHODS: We performed a comprehensive systematic literature search using 
      PubMed, Scopus, and Embase for records published from inception until 9 February 
      2021. The effect estimates were reported as relative risks (RRs). RESULTS: 
      270,229 subjects from 14 studies were included in this systematic review and 
      meta-analysis. The pooled incidence of T2DM was 9%. Meta-regression analysis 
      indicates that baseline age (coefficient: 0.67, p = 0.026), drinking 
      (coefficient: 0.03, p = 0.035), and HDL (coefficient: -0.89, p = 0.035) affected 
      the incidence of T2DM in future. High TyG index was associated with increased 
      incidence of T2DM in pooled unadjusted (RR 4.68 [3.01, 7.29], p < 0.001; I(2): 
      96.6%) and adjusted model (adjusted RR 3.54 [2.75, 4.54], p < 0.001; I(2): 
      83.7%). Dose-response meta-analysis for the adjusted RR showed that the linear 
      association analysis was not significant per 0.1 increase in TyG index (RR 1.01 
      [0.99, 1.03], p = 0.223). There is a non-linear trend (p < 0.001) for the 
      association between TyG index and incidence of T2DM. The dose-response curve 
      became increasingly steeper at TyG index above 8.6. CONCLUSIONS: TyG index was 
      associated with the incidence of T2DM in a non-linear fashion.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Pranata, Raymond
AU  - Pranata R
AUID- ORCID: 0000-0003-3998-6551
AD  - Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia. 
      raymond_pranata@hotmail.com.
FAU - Huang, Ian
AU  - Huang I
AUID- ORCID: 0000-0003-1189-8453
AD  - Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia.
AD  - Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, 
      Hasan Sadikin General Hospital, Bandung, Indonesia.
FAU - Irvan
AU  - Irvan
AD  - Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia.
FAU - Lim, Michael Anthonius
AU  - Lim MA
AD  - Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia.
FAU - Vania, Rachel
AU  - Vania R
AD  - Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20210604
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Blood Glucose
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Glucose
MH  - Humans
MH  - Incidence
MH  - Risk Factors
MH  - Triglycerides
OTO - NOTNLM
OT  - Cohort
OT  - Diabetes
OT  - Insulin resistance
OT  - Metabolic
OT  - Triglyceride-glucose index
EDAT- 2021/06/05 06:00
MHDA- 2021/10/26 06:00
CRDT- 2021/06/04 12:25
PHST- 2021/03/25 00:00 [received]
PHST- 2021/05/25 00:00 [accepted]
PHST- 2021/06/05 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/06/04 12:25 [entrez]
AID - 10.1007/s12020-021-02780-4 [pii]
AID - 10.1007/s12020-021-02780-4 [doi]
PST - ppublish
SO  - Endocrine. 2021 Nov;74(2):254-262. doi: 10.1007/s12020-021-02780-4. Epub 2021 Jun 
      4.