PMID- 34091938
OWN - NLM
STAT- MEDLINE
DCOM- 20210811
LR  - 20210811
IS  - 1439-0272 (Electronic)
IS  - 0303-4569 (Linking)
VI  - 53
IP  - 8
DP  - 2021 Sep
TI  - Milrinone ameliorates ischaemia-reperfusion injury in experimental testicular 
      torsion/detorsion rat model.
PG  - e14128
LID - 10.1111/and.14128 [doi]
AB  - This experimental study aims to evaluate the efficacy of milrinone against 
      ischaemia-reperfusion injury due to testicular torsion/detorsion. Group 1 was 
      defined as the control group. Testicular torsion/detorsion model was performed in 
      Group 2. Group 3 had similar procedures to the rats in Group 2. In addition, 
      0.5 mg/kg of milrinone was administered intraperitoneally immediately after 
      testicular torsion in Group 3. Histopathological examinations indicated a 
      dramatic improvement in terms of inflammation, haemorrhage, oedema, congestion, 
      Cosentino and Johnson scores in Group 3 compared to Group 2 (p = .037, p = .045, 
      p = .018, p = .040, p = .033 and p = .03 respectively). Blood biochemical 
      analyses, superoxide dismutase (SOD), glutathione peroxidase (GSH-px) activity 
      and total antioxidant status (TAS) levels increased significantly in Group 3 
      compared to Group 2 (p = .001, p = .024 and p < .001). Malondialdehyde (MDA), 
      protein carbonyl (PC), interleukin 1beta (IL-1beta), tumour necrosis factor-alpha 
      (TNF-alpha) and total oxidant status (TOS) levels decreased in Group 3 compared 
      to Group 2 (p = .001, p = .018, p < .001, p = .036 and p = .002 respectively). 
      Tissue biochemical analyses determined an increase in SOD and GSH-px activity in 
      Group 3 compared to Group 2, while PC and MDA levels were reduced (p = .001, 
      p < .001, p = .038 and p < .001 respectively). Milrinone attenuates 
      ischaemia-reperfusion injury that causes highly harmful effects due to testicular 
      torsion/detorsion.
CI  - (c) 2021 Wiley-VCH GmbH.
FAU - Kolukcu, Engin
AU  - Kolukcu E
AUID- ORCID: 0000-0003-3387-4428
AD  - Department of Urology, Faculty of Medicine, Gaziosmanpasa University, Tokat, 
      Turkey.
FAU - Atilgan, Dogan
AU  - Atilgan D
AUID- ORCID: 0000-0001-8584-2124
AD  - Department of Urology, Faculty of Medicine, Gaziosmanpasa University, Tokat, 
      Turkey.
FAU - Uluocak, Nihat
AU  - Uluocak N
AUID- ORCID: 0000-0001-8315-466X
AD  - Department of Urology, Faculty of Medicine, Gaziosmanpasa University, Tokat, 
      Turkey.
FAU - Deresoy, Faik Alev
AU  - Deresoy FA
AUID- ORCID: 0000-0002-2243-9394
AD  - Department of Pathology, Faculty of Medicine, Gaziosmanpasa University, Tokat, 
      Turkey.
FAU - Katar, Muzaffer
AU  - Katar M
AUID- ORCID: 0000-0002-6296-2390
AD  - Department of Biochemistry, Faculty of Medicine, Gaziosmanpasa University, Tokat, 
      Turkey.
FAU - Unsal, Velid
AU  - Unsal V
AUID- ORCID: 0000-0003-1415-0563
AD  - Faculty of Health Sciences and Central Research Laboratory, Mardin Artuklu 
      University, Mardin, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20210606
PL  - Germany
TA  - Andrologia
JT  - Andrologia
JID - 0423506
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - JU9YAX04C7 (Milrinone)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Male
MH  - Malondialdehyde
MH  - Milrinone
MH  - Rats
MH  - Rats, Wistar
MH  - *Reperfusion Injury/drug therapy/prevention & control
MH  - *Spermatic Cord Torsion/complications/drug therapy
MH  - Testis
OTO - NOTNLM
OT  - ischaemia-reperfusion injury
OT  - milrinone
OT  - testicular torsion
OT  - treatment
EDAT- 2021/06/07 06:00
MHDA- 2021/08/12 06:00
CRDT- 2021/06/06 21:23
PHST- 2021/05/07 00:00 [revised]
PHST- 2021/04/13 00:00 [received]
PHST- 2021/05/09 00:00 [accepted]
PHST- 2021/06/07 06:00 [pubmed]
PHST- 2021/08/12 06:00 [medline]
PHST- 2021/06/06 21:23 [entrez]
AID - 10.1111/and.14128 [doi]
PST - ppublish
SO  - Andrologia. 2021 Sep;53(8):e14128. doi: 10.1111/and.14128. Epub 2021 Jun 6.