PMID- 34092825
OWN - NLM
STAT- MEDLINE
DCOM- 20211227
LR  - 20220531
IS  - 2472-2448 (Electronic)
IS  - 0048-5764 (Print)
IS  - 0048-5764 (Linking)
VI  - 51
IP  - 2
DP  - 2021 Mar 16
TI  - Lamotrigine and Stevens-Johnson Syndrome Prevention.
PG  - 96-114
AB  - Stevens-Johnson Syndrome (SJS) is a rare life-threatening condition characterized 
      by severe mucocutaneous epidermal necrolysis and detachment of the epidermis. The 
      condition centers around a delayed-type hypersensitivity reaction with a complex 
      etiology stemming from a variety of causes. The number one cause is 
      medication-related-common ones including sulfonamides, antiepileptics, 
      allopurinol, and nonsteroidal anti-inflammatory drugs. Genetics also play a role 
      as several human leukocyte antigen (HLA) genotypes within certain ethnic groups 
      have been implicated in adverse reactions to specific drugs. HLAB*15:02 has been 
      identified in the Chinese and others of Southeast Asian origin to increase 
      susceptibility to lamotrigine and carbamazepine-induced SJS. Furthermore, 
      patients of Japanese origin with HLAB*31:01 and Koreans with HLA-B*44:03 are also 
      at increased risk of SJS after receiving the same two drugs. Of the 
      antiepileptics, one most commonly associated with SJS is lamotrigine, a 
      pre-synaptic voltage-gated sodium channel inhibitor. Lamotrigine is an 
      antiepileptic drug of the phenyltriazine class that is indicated for the 
      prevention of focal and generalized seizures in epileptic patients as well as 
      monotherapy or adjunctive maintenance treatment for Bipolar disorder. The 
      occurrence of SJS is not a rigid contraindication to lamotrigine reintroduction 
      in the same patient. To facilitate this, manufacturers have developed a strict 
      re-challenge dosing regimen to facilitate successful reintroduction of 
      lamotrigine. In order to prevent the recurrence of SJS during a re-challenge, 
      timing of re-dose and initial rash severity must be considered. Therefore, to 
      prevent SJS recurrence, prime lamotrigine re-challenge patients are those with 
      mild initial rash that has not occurred within the previous 4 weeks. The Federal 
      Food and Drug Administration recommends the testing HLA subtypes for those 
      associated with SJS prior to starting lamotrigine.
CI  - Copyright (c) 1964-2021 by MedWorks Media Inc, Los Angeles, CA All rights reserved. 
      Printed in the United States.
FAU - Edinoff, Amber N
AU  - Edinoff AN
AD  - Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science 
      Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, 
      LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport 
      School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State 
      University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana 
      State University Shreveport, Department of Anesthesiology, Shreveport, LA. 
      Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, 
      Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of 
      Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy 
      Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, 
      Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, 
      Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of 
      Anesthesiology, Shreveport, LA, University of Arizona College of 
      Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, 
      Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain 
      Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State 
      University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast 
      Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.
FAU - Nguyen, Long H
AU  - Nguyen LH
AD  - Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science 
      Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, 
      LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport 
      School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State 
      University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana 
      State University Shreveport, Department of Anesthesiology, Shreveport, LA. 
      Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, 
      Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of 
      Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy 
      Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, 
      Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, 
      Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of 
      Anesthesiology, Shreveport, LA, University of Arizona College of 
      Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, 
      Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain 
      Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State 
      University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast 
      Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.
FAU - Fitz-Gerald, Mary Jo
AU  - Fitz-Gerald MJ
AD  - Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science 
      Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, 
      LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport 
      School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State 
      University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana 
      State University Shreveport, Department of Anesthesiology, Shreveport, LA. 
      Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, 
      Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of 
      Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy 
      Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, 
      Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, 
      Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of 
      Anesthesiology, Shreveport, LA, University of Arizona College of 
      Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, 
      Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain 
      Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State 
      University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast 
      Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.
FAU - Crane, Erin
AU  - Crane E
AD  - Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science 
      Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, 
      LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport 
      School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State 
      University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana 
      State University Shreveport, Department of Anesthesiology, Shreveport, LA. 
      Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, 
      Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of 
      Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy 
      Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, 
      Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, 
      Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of 
      Anesthesiology, Shreveport, LA, University of Arizona College of 
      Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, 
      Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain 
      Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State 
      University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast 
      Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.
FAU - Lewis, Kyle
AU  - Lewis K
AD  - Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science 
      Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, 
      LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport 
      School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State 
      University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana 
      State University Shreveport, Department of Anesthesiology, Shreveport, LA. 
      Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, 
      Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of 
      Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy 
      Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, 
      Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, 
      Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of 
      Anesthesiology, Shreveport, LA, University of Arizona College of 
      Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, 
      Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain 
      Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State 
      University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast 
      Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.
FAU - Pierre, Samantha St
AU  - Pierre SS
AD  - Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science 
      Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, 
      LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport 
      School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State 
      University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana 
      State University Shreveport, Department of Anesthesiology, Shreveport, LA. 
      Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, 
      Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of 
      Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy 
      Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, 
      Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, 
      Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of 
      Anesthesiology, Shreveport, LA, University of Arizona College of 
      Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, 
      Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain 
      Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State 
      University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast 
      Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.
FAU - Kaye, Alan D
AU  - Kaye AD
AD  - Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science 
      Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, 
      LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport 
      School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State 
      University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana 
      State University Shreveport, Department of Anesthesiology, Shreveport, LA. 
      Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, 
      Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of 
      Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy 
      Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, 
      Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, 
      Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of 
      Anesthesiology, Shreveport, LA, University of Arizona College of 
      Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, 
      Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain 
      Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State 
      University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast 
      Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.
FAU - Kaye, Adam M
AU  - Kaye AM
AD  - Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science 
      Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, 
      LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport 
      School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State 
      University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana 
      State University Shreveport, Department of Anesthesiology, Shreveport, LA. 
      Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, 
      Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of 
      Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy 
      Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, 
      Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, 
      Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of 
      Anesthesiology, Shreveport, LA, University of Arizona College of 
      Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, 
      Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain 
      Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State 
      University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast 
      Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.
FAU - Kaye, Jessica S
AU  - Kaye JS
AD  - Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science 
      Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, 
      LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport 
      School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State 
      University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana 
      State University Shreveport, Department of Anesthesiology, Shreveport, LA. 
      Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, 
      Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of 
      Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy 
      Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, 
      Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, 
      Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of 
      Anesthesiology, Shreveport, LA, University of Arizona College of 
      Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, 
      Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain 
      Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State 
      University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast 
      Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.
FAU - Kaye, Rachel J
AU  - Kaye RJ
AD  - Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science 
      Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, 
      LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport 
      School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State 
      University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana 
      State University Shreveport, Department of Anesthesiology, Shreveport, LA. 
      Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, 
      Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of 
      Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy 
      Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, 
      Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, 
      Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of 
      Anesthesiology, Shreveport, LA, University of Arizona College of 
      Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, 
      Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain 
      Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State 
      University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast 
      Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.
FAU - Gennuso, Sonja A
AU  - Gennuso SA
AD  - Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science 
      Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, 
      LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport 
      School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State 
      University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana 
      State University Shreveport, Department of Anesthesiology, Shreveport, LA. 
      Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, 
      Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of 
      Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy 
      Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, 
      Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, 
      Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of 
      Anesthesiology, Shreveport, LA, University of Arizona College of 
      Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, 
      Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain 
      Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State 
      University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast 
      Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.
FAU - Varrassi, Giustino
AU  - Varrassi G
AD  - Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science 
      Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, 
      LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport 
      School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State 
      University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana 
      State University Shreveport, Department of Anesthesiology, Shreveport, LA. 
      Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, 
      Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of 
      Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy 
      Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, 
      Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, 
      Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of 
      Anesthesiology, Shreveport, LA, University of Arizona College of 
      Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, 
      Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain 
      Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State 
      University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast 
      Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.
FAU - Viswanath, Omar
AU  - Viswanath O
AD  - Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science 
      Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, 
      LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport 
      School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State 
      University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana 
      State University Shreveport, Department of Anesthesiology, Shreveport, LA. 
      Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, 
      Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of 
      Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy 
      Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, 
      Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, 
      Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of 
      Anesthesiology, Shreveport, LA, University of Arizona College of 
      Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, 
      Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain 
      Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State 
      University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast 
      Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.
FAU - Urits, Ivan
AU  - Urits I
AD  - Edinoff, MD, Nguyen, MD, Gerald, MD, Louisiana State University Health Science 
      Center Shreveport, Department of Psychiatry and Behavioral Medicine, Shreveport, 
      LA. Crane, BS, Lewis, BS, St Pierre, BS, Louisiana State University Shreveport 
      School of Medicine, Shreveport, LA. Alan D. Kaye, MD, PhD, Louisiana State 
      University New Orleans, Department of Anesthesiology, New Orleans, LA, Louisiana 
      State University Shreveport, Department of Anesthesiology, Shreveport, LA. 
      Gennuso, MD, Louisiana State University Shreveport, Department of Anesthesiology, 
      Shreveport, LA. Adam M. Kaye, PharmD, Jessica S. Kaye, Thomas J. Long School of 
      Pharmacy and Health Sciences, University of the Pacific, Department of Pharmacy 
      Practice, Stockton, CA. Rachel J. Kaye, BA, Medical College of South Carolina, 
      Charleston, SC. Varrassi, MD, PhD, FIPP, Paolo Procacci Foundation, Via Tacito 7, 
      Roma, Italy. Viswanath, MD, Louisiana State University Shreveport, Department of 
      Anesthesiology, Shreveport, LA, University of Arizona College of 
      Medicine-Phoenix, Phoenix, AZ, Creighton University School of Medicine, 
      Department of Anesthesiology, Omaha, NE, Valley Anesthesiology and Pain 
      Consultants-Envision Physician Services, Phoenix, AZ. Urits, MD, Louisiana State 
      University Shreveport, Department of Anesthesiology, Shreveport, LA, Southcoast 
      Health, Southcoast Physicians Group Pain Medicine, Wareham, MA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Psychopharmacol Bull
JT  - Psychopharmacology bulletin
JID - 0101123
RN  - 0 (Anticonvulsants)
RN  - 0 (HLA-B Antigens)
RN  - 33CM23913M (Carbamazepine)
RN  - U3H27498KS (Lamotrigine)
SB  - IM
MH  - *Anticonvulsants/adverse effects
MH  - Carbamazepine
MH  - HLA-B Antigens
MH  - Humans
MH  - Lamotrigine/*adverse effects
MH  - *Stevens-Johnson Syndrome/genetics/prevention & control
MH  - United States
PMC - PMC8146560
OTO - NOTNLM
OT  - HLA subtype
OT  - TEN
OT  - lamotrigine
OT  - prevention
OT  - stevens-johnson syndrome
EDAT- 2021/06/08 06:00
MHDA- 2021/12/28 06:00
PMCR- 2022/03/16
CRDT- 2021/06/07 05:42
PHST- 2021/06/07 05:42 [entrez]
PHST- 2021/06/08 06:00 [pubmed]
PHST- 2021/12/28 06:00 [medline]
PHST- 2022/03/16 00:00 [pmc-release]
PST - ppublish
SO  - Psychopharmacol Bull. 2021 Mar 16;51(2):96-114.