PMID- 34094784
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210608
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 5
DP  - 2021 May 29
TI  - Prevalence of Allergic Sensitization in Childhood Asthma.
PG  - e15311
LID - 10.7759/cureus.15311 [doi]
LID - e15311
AB  - Introduction The allergic sensitization in childhood asthma is common and the 
      prevalence varies in different geographical locations. The data on allergen 
      sensitization to guide clinicians on allergy avoidance is limited. Method This 
      prospective observational study was conducted between October 2019 and April 2020 
      on children aged two to 14 years attending an outpatient clinic. Those with 
      recurrent wheezing or physician-diagnosed asthma were interviewed; eosinophil 
      count, total serum immunoglobulin E (IgE) was measured; and skin prick test (SPT) 
      was done using standardized reagents. Wheal size of >/=3mm was considered positive. 
      Results A total of 80 children were enrolled. The mean age was 71.15 +/- 33.52 
      months (M:F ratio =1.96:1). Allergic rhinitis, conjunctivitis, and dermatosis 
      were seen in 76 (95.0%), 33 (41.3%), and 22 (27.5%) cases, respectively. The mean 
      absolute eosinophil count was 576 +/- 427per cmm. The mean total IgE was 800.9 +/- 
      883.2IU/ml. Seasonal and diurnal variations were found in 34 (42.5%) and 79 
      (98.8%) cases. Out of 1753 skin pricks using 27 reagents, 355 (20.25%) were 
      positive. Increasing age was significantly associated with increasing SPT 
      positivity (P = 0.0001). The most common sensitive aeroallergens were Kentucky 
      bluegrass (25%), Dermatophagoides pteronyssinus (22.5%), Dermatophagoides farinae 
      (21.3%), Timothy grass, and Alternaria alternans (20% each). The most common 
      sensitive food allergens were spinach (25%), banana (22.5%), carp (20%), shrimp 
      and hen's egg (18.8% each), and cow's milk (17.5%). Conclusion Increasing age was 
      associated with increasing SPT positivity in childhood asthma. The most common 
      sensitive aeroallergens were Kentucky bluegrass and 
      Dermatophagoides pteronyssinus; spinach and banana were the most common food 
      allergen.
CI  - Copyright (c) 2021, Meher et al.
FAU - Meher, Bijay Kumar
AU  - Meher BK
AD  - Pediatrics, Bhima Bhoi Medical College and Hospital, Balangir, IND.
FAU - Pradhan, Deepti D
AU  - Pradhan DD
AD  - Pediatrics, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
FAU - Mahar, Jatadhari
AU  - Mahar J
AD  - Pediatrics, Srirama Chandra Bhanja (SCB) Medical College and Hospital, Cuttack, 
      IND.
FAU - Sahu, Sanjay K
AU  - Sahu SK
AD  - Pediatrics, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
LA  - eng
PT  - Journal Article
DEP - 20210529
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8169001
OTO - NOTNLM
OT  - allergic rhinitis
OT  - asthma
OT  - immunoglobulin e
OT  - recurrent wheezing
OT  - skin prick test
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/06/08 06:00
MHDA- 2021/06/08 06:01
PMCR- 2021/05/29
CRDT- 2021/06/07 06:01
PHST- 2021/06/07 06:01 [entrez]
PHST- 2021/06/08 06:00 [pubmed]
PHST- 2021/06/08 06:01 [medline]
PHST- 2021/05/29 00:00 [pmc-release]
AID - 10.7759/cureus.15311 [doi]
PST - epublish
SO  - Cureus. 2021 May 29;13(5):e15311. doi: 10.7759/cureus.15311.