PMID- 3409517
OWN - NLM
STAT- MEDLINE
DCOM- 19881004
LR  - 20041117
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 78
IP  - 3 Pt 2
DP  - 1988 Sep
TI  - Mitral valve replacement and septal myomectomy in hypertrophic cardiomyopathy. 
      Ten-year follow-up in 80 patients.
PG  - I35-43
AB  - Between 1970 and 1980, 80 patients with hypertrophic cardiomyopathy were treated 
      with mitral valve replacement (MVR) at our institution; 54 of these (Group 1) 
      underwent MVR alone, and the remaining 26 (Group 2) underwent MVR plus septal 
      myomectomy. The 1-month mortality was 7.4% for Group 1 and 7.6% for Group 2. 
      After 10 years of follow-up, the annual mortality was 1.5% for Group 1 and 1.6% 
      for Group 2 (this difference was not significant). Sixty-nine percent of the 
      patients in both groups continued to experience marked symptomatic improvement. 
      In Group 1, 96% of the patients had been assigned to New York Heart Association 
      (NYHA) functional class III or IV before surgery; only 17% remained in these two 
      classes postoperatively (p less than 0.01). In Group 2, 98% had been assigned to 
      NYHA functional class III or IV before surgery, whereas only 20% remained in 
      these two classes postoperatively (p less than 0.01). A comparison of 
      preoperative and postoperative hemodynamic findings revealed that the left 
      ventricular end-diastolic pressure was significantly reduced from 20 to 14 mm Hg 
      in Group 1 and from 20 to 15 mm Hg in Group II (p less than 0.05). There was also 
      a significant postoperative reduction in left ventricular outflow gradient at 
      rest (from 79 to 6 mm Hg in Group 1 and from 75 to 7 mm Hg in Group 2) (p less 
      than 0.01). These findings indicate that, in patients with hypertrophic 
      cardiomyopathy who require surgical treatment, MVR alone or in conjunction with 
      septal myomectomy offers significant improvement of symptoms and hemodynamic 
      values.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Krajcer, Z
AU  - Krajcer Z
AD  - Division of Cardiology, Texas Heart Institute, Houston.
FAU - Leachman, R D
AU  - Leachman RD
FAU - Cooley, D A
AU  - Cooley DA
FAU - Ostojic, M
AU  - Ostojic M
FAU - Coronado, R
AU  - Coronado R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/mortality/physiopathology/*surgery
MH  - Child
MH  - Endocarditis, Bacterial/etiology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart/physiopathology
MH  - Heart Septum/*surgery
MH  - *Heart Valve Prosthesis/adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/physiopathology/*surgery
MH  - Postoperative Complications
MH  - Prosthesis Failure
EDAT- 1988/09/01 00:00
MHDA- 1988/09/01 00:01
CRDT- 1988/09/01 00:00
PHST- 1988/09/01 00:00 [pubmed]
PHST- 1988/09/01 00:01 [medline]
PHST- 1988/09/01 00:00 [entrez]
PST - ppublish
SO  - Circulation. 1988 Sep;78(3 Pt 2):I35-43.