PMID- 34095447
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220423
IS  - 2352-9067 (Print)
IS  - 2352-9067 (Electronic)
IS  - 2352-9067 (Linking)
VI  - 34
DP  - 2021 Jun
TI  - The relation between the atrial blood supply and the complexity of acute atrial 
      fibrillation.
PG  - 100794
LID - 10.1016/j.ijcha.2021.100794 [doi]
LID - 100794
AB  - BACKGROUND: Patients with a history of myocardial infarction and coronary artery 
      disease (CAD) have a higher risk of developing AF. Conversely, patients with 
      atrial fibrillation (AF) have a higher risk of developing myocardial infarction, 
      suggesting a link in underlying pathophysiology. The aim of this study was to 
      assess whether coronary angiographic parameters are associated with a substrate 
      for AF in patients without a history of AF. METHODS: During cardiac surgery in 62 
      patients (coronary artery bypass grafting (CABG;n = 47), aortic valve replacement 
      (AVR;n = 9) or CABG + AVR (n = 6)) without a history of clinical AF (age 
      65.4 +/- 8.5 years, 26.2% female), AF was induced by burst pacing. The preoperative 
      coronary angiogram (CAG) was assessed for the severity of CAD, and the adequacy 
      of atrial coronary blood supply as quantified by a novel scoring system including 
      the location and severity of right coronary artery disease in relation to the 
      right atrial branches. Epicardial mapping of the right atrium (256 unipolar 
      electrodes) was used to assess the complexity of induced AF. RESULTS: There was 
      no association between the adequacy of right atrial coronary blood supply on 
      preoperative CAG and AF complexity parameters. Multivariable analysis revealed 
      that only increasing age (B0.232 (0.030;0.433),p = 0.03) and the presence of 3VD 
      (B3.602 (0.187;7.018),p = 0.04) were independently associated with an increased 
      maximal activation time difference. CONCLUSIONS: The adequacy of epicardial right 
      atrial blood supply is not associated with increased complexity of induced atrial 
      fibrillation in patients without a history of clinical AF, while age and the 
      extent of ventricular coronary artery disease are.
CI  - (c) 2021 Published by Elsevier B.V.
FAU - Dudink, Elton A M P
AU  - Dudink EAMP
AD  - Maastricht University Medical Center (MUMC+) and Cardiovascular Research 
      Institute Maastricht (CARIM), Department of Cardiology, P. Debyelaan 25, 6229 HX 
      Maastricht, the Netherlands.
FAU - Bidar, Elham
AU  - Bidar E
AD  - Maastricht University Medical Center (MUMC+) and Cardiovascular Research 
      Institute Maastricht (CARIM), Department of Cardiothoracic Surgery, P. Debyelaan 
      25, 6229 HX Maastricht, the Netherlands.
AD  - Maastricht University and Cardiovascular Research Institute Maastricht (CARIM), 
      Department of Physiology, Universiteitssingel 50, 6229 ER Maastricht, the 
      Netherlands.
FAU - Jacobs, Judith
AU  - Jacobs J
AD  - Maastricht University Medical Center (MUMC+) and Cardiovascular Research 
      Institute Maastricht (CARIM), Department of Cardiology, P. Debyelaan 25, 6229 HX 
      Maastricht, the Netherlands.
FAU - van Hunnik, Arne
AU  - van Hunnik A
AD  - Maastricht University and Cardiovascular Research Institute Maastricht (CARIM), 
      Department of Physiology, Universiteitssingel 50, 6229 ER Maastricht, the 
      Netherlands.
FAU - Zeemering, Stef
AU  - Zeemering S
AD  - Maastricht University and Cardiovascular Research Institute Maastricht (CARIM), 
      Department of Physiology, Universiteitssingel 50, 6229 ER Maastricht, the 
      Netherlands.
FAU - Weijs, Bob
AU  - Weijs B
AD  - Maastricht University Medical Center (MUMC+) and Cardiovascular Research 
      Institute Maastricht (CARIM), Department of Cardiology, P. Debyelaan 25, 6229 HX 
      Maastricht, the Netherlands.
FAU - Luermans, Justin G L M
AU  - Luermans JGLM
AD  - Maastricht University Medical Center (MUMC+) and Cardiovascular Research 
      Institute Maastricht (CARIM), Department of Cardiology, P. Debyelaan 25, 6229 HX 
      Maastricht, the Netherlands.
FAU - Maesen, Bart A E
AU  - Maesen BAE
AD  - Maastricht University Medical Center (MUMC+) and Cardiovascular Research 
      Institute Maastricht (CARIM), Department of Cardiothoracic Surgery, P. Debyelaan 
      25, 6229 HX Maastricht, the Netherlands.
FAU - Cheriex, Emile C
AU  - Cheriex EC
AD  - Maastricht University Medical Center (MUMC+) and Cardiovascular Research 
      Institute Maastricht (CARIM), Department of Cardiology, P. Debyelaan 25, 6229 HX 
      Maastricht, the Netherlands.
FAU - Maessen, Jos G
AU  - Maessen JG
AD  - Maastricht University Medical Center (MUMC+) and Cardiovascular Research 
      Institute Maastricht (CARIM), Department of Cardiothoracic Surgery, P. Debyelaan 
      25, 6229 HX Maastricht, the Netherlands.
FAU - Hoorntje, Jan C A
AU  - Hoorntje JCA
AD  - Maastricht University Medical Center (MUMC+) and Cardiovascular Research 
      Institute Maastricht (CARIM), Department of Cardiology, P. Debyelaan 25, 6229 HX 
      Maastricht, the Netherlands.
FAU - Schotten, Ulrich
AU  - Schotten U
AD  - Maastricht University and Cardiovascular Research Institute Maastricht (CARIM), 
      Department of Physiology, Universiteitssingel 50, 6229 ER Maastricht, the 
      Netherlands.
FAU - Crijns, Harry J G M
AU  - Crijns HJGM
AD  - Maastricht University Medical Center (MUMC+) and Cardiovascular Research 
      Institute Maastricht (CARIM), Department of Cardiology, P. Debyelaan 25, 6229 HX 
      Maastricht, the Netherlands.
FAU - Verheule, Sander
AU  - Verheule S
AD  - Maastricht University and Cardiovascular Research Institute Maastricht (CARIM), 
      Department of Physiology, Universiteitssingel 50, 6229 ER Maastricht, the 
      Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20210519
PL  - Ireland
TA  - Int J Cardiol Heart Vasc
JT  - International journal of cardiology. Heart & vasculature
JID - 101649525
CIN - Int J Cardiol Heart Vasc. 2021 Jun 09;34:100816. PMID: 34169141
PMC - PMC8164021
OTO - NOTNLM
OT  - Atrial fibrillation complexity
OT  - Atrial fibrillation substrate
OT  - Coronary artery disease
COIS- The authors report no relationships that could be construed as a conflict of 
      interest.
EDAT- 2021/06/08 06:00
MHDA- 2021/06/08 06:01
PMCR- 2021/05/19
CRDT- 2021/06/07 06:07
PHST- 2021/02/09 00:00 [received]
PHST- 2021/04/30 00:00 [revised]
PHST- 2021/05/04 00:00 [accepted]
PHST- 2021/06/07 06:07 [entrez]
PHST- 2021/06/08 06:00 [pubmed]
PHST- 2021/06/08 06:01 [medline]
PHST- 2021/05/19 00:00 [pmc-release]
AID - S2352-9067(21)00082-8 [pii]
AID - 100794 [pii]
AID - 10.1016/j.ijcha.2021.100794 [doi]
PST - epublish
SO  - Int J Cardiol Heart Vasc. 2021 May 19;34:100794. doi: 
      10.1016/j.ijcha.2021.100794. eCollection 2021 Jun.