PMID- 34095873
OWN - NLM
STAT- MEDLINE
DCOM- 20220301
LR  - 20220301
IS  - 2666-3791 (Electronic)
IS  - 2666-3791 (Linking)
VI  - 2
IP  - 5
DP  - 2021 May 18
TI  - A rich meconium metabolome in human infants is associated with early-life gut 
      microbiota composition and reduced allergic sensitization.
PG  - 100260
LID - 10.1016/j.xcrm.2021.100260 [doi]
LID - 100260
AB  - Microbiota maturation and immune development occur in parallel with, and are 
      implicated in, allergic diseases, and research has begun to demonstrate the 
      importance of prenatal influencers on both. Here, we investigate the meconium 
      metabolome, a critical link between prenatal exposures and both early microbiota 
      and immune development, to identify components of the neonatal gut niche that 
      contribute to allergic sensitization. Our analysis reveals that newborns who 
      develop immunoglobulin E (IgE)-mediated allergic sensitization (atopy) by 1 year 
      of age have a less-diverse gut metabolome at birth, and specific metabolic 
      clusters are associated with both protection against atopy and the abundance of 
      key taxa driving microbiota maturation. These metabolic signatures, when coupled 
      with early-life microbiota and clinical factors, increase our ability to 
      accurately predict whether or not infants will develop atopy. Thus, the 
      trajectory of both microbiota colonization and immune development are 
      significantly affected by metabolites present in the neonatal gut at birth.
CI  - Crown Copyright (c) 2021.
FAU - Petersen, Charisse
AU  - Petersen C
AD  - Michael Smith Laboratories, University of British Columbia, Vancouver, BC, 
      Canada.
AD  - Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
AD  - British Columbia Children's Hospital, Vancouver, BC, Canada.
FAU - Dai, Darlene L Y
AU  - Dai DLY
AD  - Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
AD  - British Columbia Children's Hospital, Vancouver, BC, Canada.
FAU - Boutin, Rozlyn C T
AU  - Boutin RCT
AD  - Michael Smith Laboratories, University of British Columbia, Vancouver, BC, 
      Canada.
FAU - Sbihi, Hind
AU  - Sbihi H
AD  - Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
AD  - British Columbia Children's Hospital, Vancouver, BC, Canada.
FAU - Sears, Malcolm R
AU  - Sears MR
AD  - McMaster University, Hamilton, ON, Canada.
FAU - Moraes, Theo J
AU  - Moraes TJ
AD  - Hospital for Sick Children & University of Toronto, Toronto, ON, Canada.
FAU - Becker, Allan B
AU  - Becker AB
AD  - Children's Hospital Research Institute of Manitoba, Department of Pediatrics and 
      Child Health, University of Manitoba, Winnipeg, MB, Canada.
FAU - Azad, Meghan B
AU  - Azad MB
AD  - Children's Hospital Research Institute of Manitoba, Department of Pediatrics and 
      Child Health, University of Manitoba, Winnipeg, MB, Canada.
FAU - Mandhane, Piush J
AU  - Mandhane PJ
AD  - University of Alberta, Edmonton, AB, Canada.
FAU - Subbarao, Padmaja
AU  - Subbarao P
AD  - McMaster University, Hamilton, ON, Canada.
AD  - Hospital for Sick Children & University of Toronto, Toronto, ON, Canada.
FAU - Turvey, Stuart E
AU  - Turvey SE
AD  - Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
AD  - British Columbia Children's Hospital, Vancouver, BC, Canada.
FAU - Finlay, B Brett
AU  - Finlay BB
AD  - Michael Smith Laboratories, University of British Columbia, Vancouver, BC, 
      Canada.
AD  - Department of Microbiology and Immunology, University of British Columbia, 
      Vancouver, BC, Canada.
AD  - Department of Biochemistry, University of British Columbia, Vancouver, BC, 
      Canada.
LA  - eng
GR  - AEC-85761/CIHR/Canada
GR  - PJT-148484/CIHR/Canada
GR  - FDN-159935/CIHR/Canada
GR  - EC1-144621/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210429
PL  - United States
TA  - Cell Rep Med
JT  - Cell reports. Medicine
JID - 101766894
RN  - 0 (RNA, Ribosomal, 16S)
RN  - 37341-29-0 (Immunoglobulin E)
MH  - Female
MH  - Gastrointestinal Microbiome/*immunology
MH  - Humans
MH  - Hypersensitivity, Immediate/*genetics
MH  - Immunoglobulin E/metabolism
MH  - Infant
MH  - Infant, Newborn
MH  - Meconium/*microbiology
MH  - Metabolome/genetics/*physiology
MH  - Microbiota/physiology
MH  - Pregnancy
MH  - RNA, Ribosomal, 16S/genetics
PMC - PMC8149367
OTO - NOTNLM
OT  - allergic sensitization
OT  - early-life window
OT  - meconium
OT  - metabolome
OT  - microbiota maturation
OT  - neonatal niche
OT  - newborn
COIS- The authors declare no competing interests.
EDAT- 2021/06/08 06:00
MHDA- 2021/06/08 06:01
PMCR- 2021/04/29
CRDT- 2021/06/07 06:14
PHST- 2019/07/23 00:00 [received]
PHST- 2021/01/20 00:00 [revised]
PHST- 2021/04/02 00:00 [accepted]
PHST- 2021/06/07 06:14 [entrez]
PHST- 2021/06/08 06:00 [pubmed]
PHST- 2021/06/08 06:01 [medline]
PHST- 2021/04/29 00:00 [pmc-release]
AID - S2666-3791(21)00076-8 [pii]
AID - 100260 [pii]
AID - 10.1016/j.xcrm.2021.100260 [doi]
PST - epublish
SO  - Cell Rep Med. 2021 Apr 29;2(5):100260. doi: 10.1016/j.xcrm.2021.100260. 
      eCollection 2021 May 18.