PMID- 34096448
OWN - NLM
STAT- MEDLINE
DCOM- 20220602
LR  - 20220610
IS  - 1532-4281 (Electronic)
IS  - 1079-9893 (Linking)
VI  - 42
IP  - 3
DP  - 2022 Jun
TI  - MicroRNA-320a-containing exosomes from human umbilical cord mesenchymal stem 
      cells curtail proliferation and metastasis in lung cancer by binding to SOX4.
PG  - 268-278
LID - 10.1080/10799893.2021.1918166 [doi]
AB  - Exosomes from human umbilical cord mesenchymal stem cells (HUCMSCs) containing 
      microRNAs (miRNAs) have been underscored as possible therapeutic options for 
      cancers. Hence, our goal here was to investigate the relevance of 
      miR-320a-containing exosomes from HUCMSCs to lung cancer. First, H1299 and H460 
      cells were co-cultured with the exosomes overexpressing miR-320a from HUCMSCs. 
      The data displayed that HUCMSCs-secreted exosomes expressing miR-320a exerted 
      anti-tumor effects in vitro and in vivo. Online analysis available at TargetScan 
      database revealed that miR-320a bound to sex-determining region Y-box 4 (SOX4), 
      and the luciferase reporter gene assay clarified this targeting relationship. 
      Next, a beta-catenin-specific agonist WAY-262611 was delivered into the H1299 and 
      H460 cells to assess the effects of the Wnt/beta-catenin pathway on lung cancer 
      cellular processes. The results demonstrated that WAY-262611 potentiated lung 
      cancer cell viability, invasion, and migration, but inhibited cell apoptosis. 
      Altogether, exosomes carrying miR-320a from HUCMSCs might suppress lung cancer 
      cell growth via the SOX4/Wnt/beta-catenin axis, which highpoints the potency of 
      exosomes expressing miR-320a as a possible therapeutic option for lung cancer 
      treatment.
FAU - Xie, Huan
AU  - Xie H
AD  - Department of Respiratory Medicine, Shengzhou People's Hospital (the First 
      Affiliated Hospital of Zhejiang University Shengzhou Branch), Shengzhou, 
      Zhejiang, P.R. China.
FAU - Wang, Jie
AU  - Wang J
AD  - Department of Respiratory Medicine, Shengzhou People's Hospital (the First 
      Affiliated Hospital of Zhejiang University Shengzhou Branch), Shengzhou, 
      Zhejiang, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20210607
PL  - England
TA  - J Recept Signal Transduct Res
JT  - Journal of receptor and signal transduction research
JID - 9509432
RN  - 0 (MicroRNAs)
RN  - 0 (SOX4 protein, human)
RN  - 0 (SOXC Transcription Factors)
RN  - 0 (beta Catenin)
SB  - IM
MH  - Cell Proliferation/genetics
MH  - *Exosomes/genetics/metabolism/pathology
MH  - Humans
MH  - *Lung Neoplasms/pathology
MH  - *Mesenchymal Stem Cells/metabolism
MH  - *MicroRNAs/genetics/metabolism
MH  - SOXC Transcription Factors/genetics/metabolism
MH  - Umbilical Cord/metabolism
MH  - beta Catenin/genetics
OTO - NOTNLM
OT  - Human umbilical cord mesenchymal stem cells
OT  - SOX4
OT  - exosomes
OT  - lung cancer
OT  - microRNA-320a
OT  - the Wnt/beta-catenin pathway
EDAT- 2021/06/08 06:00
MHDA- 2022/06/03 06:00
CRDT- 2021/06/07 08:51
PHST- 2021/06/08 06:00 [pubmed]
PHST- 2022/06/03 06:00 [medline]
PHST- 2021/06/07 08:51 [entrez]
AID - 10.1080/10799893.2021.1918166 [doi]
PST - ppublish
SO  - J Recept Signal Transduct Res. 2022 Jun;42(3):268-278. doi: 
      10.1080/10799893.2021.1918166. Epub 2021 Jun 7.