PMID- 34097568
OWN - NLM
STAT- MEDLINE
DCOM- 20220307
LR  - 20220307
IS  - 1502-7686 (Electronic)
IS  - 0036-5513 (Linking)
VI  - 81
IP  - 5
DP  - 2021 Sep
TI  - A rare case of IgE kappa monoclonal gammopathy of undetermined significance 
      identified in a Swedish female.
PG  - 385-388
LID - 10.1080/00365513.2021.1929443 [doi]
AB  - Monoclonal gammopathies involving immunoglobulin E (IgE) is a very rare 
      phenomenon, with less than 70 cases being previously described in the literature. 
      The IgE monoclonal gammopathies include malignant plasma cell disorders such as 
      IgE multiple myeloma (MM), as well as the associated premalignant condition IgE 
      monoclonal gammopathy of undetermined significance (MGUS). We report a case of a 
      41-year-old woman presenting with an IgE kappa monoclonal protein following 
      routine laboratory testing. Serum protein electrophoresis (SPEP) initially showed 
      a monoclonal protein in the beta-2 fraction, at an estimated concentration of 
      <4 g/L. Subsequent serum immunofixation electrophoresis (SIFE) including antisera 
      to Ig heavy chains delta and epsilon confirmed the presence of an IgE kappa 
      monoclonal protein. Analysis of serum free light chains (FLCs) showed increased 
      levels of kappa FLC, resulting in an abnormally elevated kappa/lambda FLC ratio. 
      No Bence-Jones proteinuria was present. Bone marrow aspiration showed 6% plasma 
      cells, and no sign of myeloma-associated end-organ damage was evident. 
      Consequently, the patient was diagnosed with IgE kappa MGUS. In the present 
      report, the clinical characteristics of the patient are compared to previous 
      descriptions of IgE monoclonal gammopathy. The report further emphasizes the 
      importance of considering the presence of monoclonal IgD or IgE when SIFE shows a 
      clear band positive for a light chain but is negative for Ig heavy chains gamma, 
      alpha and mu.
FAU - Fager Ferrari, Marcus
AU  - Fager Ferrari M
AD  - Department of Hematology, Skane University Hospital, Malmo, Sweden.
FAU - Lemonakis, Konstantinos
AU  - Lemonakis K
AD  - Department of Hematology, Skane University Hospital, Malmo, Sweden.
FAU - Fornvik Jonsson, Magnus
AU  - Fornvik Jonsson M
AD  - Department of Clinical Chemistry, Skane University Hospital, Malmo, Sweden.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20210607
PL  - England
TA  - Scand J Clin Lab Invest
JT  - Scandinavian journal of clinical and laboratory investigation
JID - 0404375
RN  - 0 (Blood Proteins)
RN  - 0 (Immunoglobulin kappa-Chains)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Blood Proteins/analysis
MH  - Electrophoresis
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Immunoglobulin kappa-Chains/*blood
MH  - Monoclonal Gammopathy of Undetermined Significance/blood/*diagnosis
MH  - Multiple Myeloma/diagnosis
OTO - NOTNLM
OT  - Electrophoresis
OT  - immunoglobulin E
OT  - immunoglobulin kappa-chains
OT  - monoclonal gammopathy of undetermined significance
OT  - multiple myeloma
OT  - paraproteinemias
EDAT- 2021/06/08 06:00
MHDA- 2022/03/08 06:00
CRDT- 2021/06/07 17:14
PHST- 2021/06/08 06:00 [pubmed]
PHST- 2022/03/08 06:00 [medline]
PHST- 2021/06/07 17:14 [entrez]
AID - 10.1080/00365513.2021.1929443 [doi]
PST - ppublish
SO  - Scand J Clin Lab Invest. 2021 Sep;81(5):385-388. doi: 
      10.1080/00365513.2021.1929443. Epub 2021 Jun 7.