PMID- 34098365
OWN - NLM
STAT- MEDLINE
DCOM- 20210720
LR  - 20210720
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 205
DP  - 2021 Sep
TI  - Cholesterol modulates the interaction between paclitaxel and Langmuir monolayers 
      simulating cell membranes.
PG  - 111889
LID - S0927-7765(21)00333-7 [pii]
LID - 10.1016/j.colsurfb.2021.111889 [doi]
AB  - The composition of Langmuir monolayers used as cell membrane models is an 
      essential factor for the interaction with biologically-relevant molecules, 
      including pharmaceutical drugs. In this paper, we report the modulation of 
      effects from the antineoplastic drug paclitaxel by the relative concentration of 
      cholesterol in the Langmuir monolayers of ternary mixtures of 
      dipalmitoylphosphatidylcholine, sphingomyelin, and cholesterol. Since the 
      dependence on cholesterol concentration for these monolayers simulating lipid 
      rafts is non-monotonic, we analyzed the surface pressure and compressibility 
      modulus data with the multidimensional projection technique referred to as 
      interactive document mapping (IDMAP). The maximum expansion induced by paclitaxel 
      in surface pressure isotherms was observed for 27% cholesterol, while the 
      compressibility modulus decreased most strongly for the monolayer with 48% 
      cholesterol. Therefore, the physiological action of paclitaxel may vary depending 
      on whether it is associated with penetration in the membrane or with changes in 
      the membrane elasticity.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Pereira, Andressa R
AU  - Pereira AR
AD  - Sao Carlos Institute of Physics, University of Sao Paulo, SP, Brazil.
FAU - Shimizu, Flavio M
AU  - Shimizu FM
AD  - Department of Applied Physics, "Gleb Wataghin" Institute of Physics (IFGW), 
      University of Campinas (UNICAMP), Campinas, SP, Brazil.
FAU - Oliveira, Osvaldo N Jr
AU  - Oliveira ON Jr
AD  - Sao Carlos Institute of Physics, University of Sao Paulo, SP, Brazil. Electronic 
      address: chu@ifsc.usp.br.
LA  - eng
PT  - Journal Article
DEP - 20210531
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Membranes, Artificial)
RN  - 0 (Sphingomyelins)
RN  - 2644-64-6 (1,2-Dipalmitoylphosphatidylcholine)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - P88XT4IS4D (Paclitaxel)
SB  - IM
MH  - *1,2-Dipalmitoylphosphatidylcholine
MH  - Cell Membrane
MH  - Cholesterol
MH  - Membranes, Artificial
MH  - *Paclitaxel
MH  - Sphingomyelins
OTO - NOTNLM
OT  - Cholesterol
OT  - DPPC
OT  - Langmuir monolayers
OT  - Lipid rafts
OT  - Paclitaxel
EDAT- 2021/06/08 06:00
MHDA- 2021/07/21 06:00
CRDT- 2021/06/07 20:24
PHST- 2021/03/27 00:00 [received]
PHST- 2021/05/19 00:00 [revised]
PHST- 2021/05/28 00:00 [accepted]
PHST- 2021/06/08 06:00 [pubmed]
PHST- 2021/07/21 06:00 [medline]
PHST- 2021/06/07 20:24 [entrez]
AID - S0927-7765(21)00333-7 [pii]
AID - 10.1016/j.colsurfb.2021.111889 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2021 Sep;205:111889. doi: 
      10.1016/j.colsurfb.2021.111889. Epub 2021 May 31.