PMID- 34101025
OWN - NLM
STAT- MEDLINE
DCOM- 20210922
LR  - 20210922
IS  - 1432-0932 (Electronic)
IS  - 0940-6719 (Linking)
VI  - 30
IP  - 8
DP  - 2021 Aug
TI  - Lack of association between TNF polymorphism and ankylosing spondylitis 
      susceptibility in HLA-B27-positive population: a meta-analysis.
PG  - 2401-2408
LID - 10.1007/s00586-021-06892-3 [doi]
AB  - OBJECTIVE: Human leukocyte antigen (HLA)-B27 plays a crucial role in the 
      pathogenesis of AS. TNF polymorphisms have been reported to be associated with AS 
      susceptibility, but the results of these previous studies have been inconsistent. 
      The aim of this study was to explore whether TNF polymorphism is associated with 
      AS susceptibility in HLA-27-positive population. METHODS: Our search was done in 
      the Pubmed, Embase, and Cochrane databases (up to March 2020). The pooled and 
      individual odds ratios (ORs) with 95% confidence intervals (CIs) of the minor 
      allele of each locus were presented to assess the associations between TNF 
      polymorphisms and AS in HLA-B27-positive population. RESULTS: Ten studies from 8 
      articles were included in this meta-analysis. In the population of 
      HLA-B27-positive patients and random healthy controls, there were statistical 
      significance in the evaluation of association between the minor allele of 
      TNF-238, -308, -857, -1031 and -863 and AS susceptibility, respectively. In the 
      population of HLA-B27-positive patients and HLA-B27-positive healthy controls, 
      there were no statistical differences in the comparison of minor allele of with 
      their respective major allele in the fixed model. CONCLUSIONS: There was no 
      association of the TNF polymorphisms with AS in the HLA-B27-positive AS group and 
      HLA-B27-positive control group. Polymorphisms of TNF-238, -308, -857, -1031, -863 
      were associated with AS susceptibility in the HLA-B27-positive AS patients and 
      random control population. Other gene SNPs except TNF may play an important role 
      in AS susceptibility in HLA-B27-positive population.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Hu, Naiwen
AU  - Hu N
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, 
      Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, Cheeloo 
      College of Medicine, Shandong University, Jinan, 250021, Shandong, China.
FAU - Liu, Dongxia
AU  - Liu D
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, 
      Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, Cheeloo 
      College of Medicine, Shandong University, Jinan, 250021, Shandong, China.
FAU - Zhao, Na
AU  - Zhao N
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, 
      Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, Cheeloo 
      College of Medicine, Shandong University, Jinan, 250021, Shandong, China.
FAU - Wang, Xia
AU  - Wang X
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, 
      Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, Cheeloo 
      College of Medicine, Shandong University, Jinan, 250021, Shandong, China.
FAU - Bai, Yanyan
AU  - Bai Y
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, 
      Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. 
      714466429@qq.com.
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, Cheeloo 
      College of Medicine, Shandong University, Jinan, 250021, Shandong, China. 
      714466429@qq.com.
FAU - Sun, Hongsheng
AU  - Sun H
AUID- ORCID: 0000-0002-6528-4679
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, 
      Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. 
      229264076@qq.com.
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, Cheeloo 
      College of Medicine, Shandong University, Jinan, 250021, Shandong, China. 
      229264076@qq.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20210608
PL  - Germany
TA  - Eur Spine J
JT  - European spine journal : official publication of the European Spine Society, the 
      European Spinal Deformity Society, and the European Section of the Cervical Spine 
      Research Society
JID - 9301980
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/genetics
MH  - *HLA-B27 Antigen/genetics
MH  - Humans
MH  - Polymorphism, Single Nucleotide/genetics
MH  - *Spondylitis, Ankylosing/genetics
OTO - NOTNLM
OT  - Ankylosing spondylitis
OT  - HLA-B27
OT  - Meta-analysis
OT  - Polymorphisms
OT  - TNF
EDAT- 2021/06/09 06:00
MHDA- 2021/09/23 06:00
CRDT- 2021/06/08 12:28
PHST- 2021/04/05 00:00 [received]
PHST- 2021/05/29 00:00 [accepted]
PHST- 2021/05/24 00:00 [revised]
PHST- 2021/06/09 06:00 [pubmed]
PHST- 2021/09/23 06:00 [medline]
PHST- 2021/06/08 12:28 [entrez]
AID - 10.1007/s00586-021-06892-3 [pii]
AID - 10.1007/s00586-021-06892-3 [doi]
PST - ppublish
SO  - Eur Spine J. 2021 Aug;30(8):2401-2408. doi: 10.1007/s00586-021-06892-3. Epub 2021 
      Jun 8.