PMID- 34101411
OWN - NLM
STAT- MEDLINE
DCOM- 20210805
LR  - 20240226
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 13
IP  - 24
DP  - 2021 Jun 23
TI  - Protein-Gated Upconversion Nanoparticle-Embedded Mesoporous Silica Nanovehicles 
      via Diselenide Linkages for Drug Release Tracking in Real Time and Tumor 
      Chemotherapy.
PG  - 29070-29082
LID - 10.1021/acsami.1c04447 [doi]
AB  - Two novel stimuli-responsive drug delivery systems (DDSs) were successfully 
      created from bovine serum albumin- or myoglobin-gated upconversion 
      nanoparticle-embedded mesoporous silica nanovehicles (UCNP@mSiO(2)) via 
      diselenide (Se-Se)-containing linkages. More importantly, multiple roles of each 
      scaffold of the nanovehicles were achieved. The controlled release of the 
      encapsulated drug doxorubicin (DOX) within the mesopores was activated by triple 
      stimuli (acidic pH, glutathione, or H(2)O(2)) of tumor microenvironments, owing 
      to the conformation/surface charge changes in proteins or the reductive/oxidative 
      cleavages of the Se-Se bonds. Upon release of DOX, the Forster resonance energy 
      transfer between the UCNP cores and encapsulated DOX was eliminated, resulting in 
      an increase in ratiometric upconversion luminescence for DOX release tracking in 
      real time. The two protein-gated DDSs showed some differences in the drug release 
      performances, relevant to structures and properties of the protein nanogates. The 
      introduction of the Se-Se linkages not only increased the versatility of 
      reductive/oxidative cleavages but also showed less cytotoxicity to all cell 
      lines. The DOX-loaded protein-gated nanovehicles showed the inhibitory effect on 
      tumor growth in tumor-bearing mice and negligible damage/toxicity to the normal 
      tissues. The constructed nanovehicles in a spatiotemporally controlled manner 
      have fascinating prospects in targeted drug delivery for cancer chemotherapy.
FAU - Yan, Hua
AU  - Yan H
AD  - Key Laboratory of Mesoscopic Chemistry (Ministry of Education), State Key 
      Laboratory of Coordination Chemistry, and School of Chemistry and Chemical 
      Engineering, Nanjing University, Nanjing 210023, People's Republic of China.
AD  - School of Pharmaceutical and Materials Engineering, Taizhou University, Taizhou, 
      Zhejiang Province 318000, People's Republic of China.
FAU - Dong, Jiangtao
AU  - Dong J
AD  - Key Laboratory of Mesoscopic Chemistry (Ministry of Education), State Key 
      Laboratory of Coordination Chemistry, and School of Chemistry and Chemical 
      Engineering, Nanjing University, Nanjing 210023, People's Republic of China.
FAU - Huang, Xuan
AU  - Huang X
AD  - Key Laboratory of Mesoscopic Chemistry (Ministry of Education), State Key 
      Laboratory of Coordination Chemistry, and School of Chemistry and Chemical 
      Engineering, Nanjing University, Nanjing 210023, People's Republic of China.
FAU - Du, Xuezhong
AU  - Du X
AUID- ORCID: 0000-0003-2492-1085
AD  - Key Laboratory of Mesoscopic Chemistry (Ministry of Education), State Key 
      Laboratory of Coordination Chemistry, and School of Chemistry and Chemical 
      Engineering, Nanjing University, Nanjing 210023, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210608
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Myoglobin)
RN  - 0 (sodium yttriumtetrafluoride)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 58784XQC3Y (Yttrium)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 77B218D3YE (Erbium)
RN  - 80168379AG (Doxorubicin)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - GAN16C9B8O (Glutathione)
RN  - MNQ4O4WSI1 (Ytterbium)
RN  - Q80VPU408O (Fluorides)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/chemistry/*therapeutic use
MH  - Cattle
MH  - Doxorubicin/chemistry/*therapeutic use
MH  - Drug Carriers/*chemistry/metabolism
MH  - Drug Liberation
MH  - Erbium/chemistry
MH  - Female
MH  - Fluorides/chemistry
MH  - Glutathione/metabolism
MH  - HeLa Cells
MH  - Humans
MH  - Hydrogen Peroxide/metabolism
MH  - Hydrogen-Ion Concentration
MH  - Metal Nanoparticles/*chemistry
MH  - Mice, Inbred C57BL
MH  - Myoglobin/chemistry/metabolism
MH  - Neoplasms/*drug therapy
MH  - Porosity
MH  - Serum Albumin, Bovine/chemistry/metabolism
MH  - Silicon Dioxide/chemistry
MH  - Xenograft Model Antitumor Assays
MH  - Ytterbium/chemistry
MH  - Yttrium/chemistry
MH  - Mice
OTO - NOTNLM
OT  - diselenide bonds
OT  - drug delivery
OT  - protein nanogates
OT  - tumor therapy
OT  - upconversion nanoparticles
EDAT- 2021/06/09 06:00
MHDA- 2021/08/06 06:00
CRDT- 2021/06/08 17:18
PHST- 2021/06/09 06:00 [pubmed]
PHST- 2021/08/06 06:00 [medline]
PHST- 2021/06/08 17:18 [entrez]
AID - 10.1021/acsami.1c04447 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2021 Jun 23;13(24):29070-29082. doi: 
      10.1021/acsami.1c04447. Epub 2021 Jun 8.