PMID- 34101817
OWN - NLM
STAT- MEDLINE
DCOM- 20220418
LR  - 20220418
IS  - 1708-8305 (Electronic)
IS  - 1195-1982 (Linking)
VI  - 28
IP  - 8
DP  - 2021 Dec 29
TI  - Safety of measles, rubella and mumps vaccines in adults: a prospective cohort 
      study.
LID - taab071 [pii]
LID - 10.1093/jtm/taab071 [doi]
AB  - BACKGROUND: In recent years, multiple outbreaks of measles associated with 
      vaccine hesitancy occurred in high-income countries, where measles incidence had 
      previously been low. Most safety data about the measles, mumps and rubella (MMR) 
      vaccine are derived from studies conducted among children, whereas evidence 
      regarding the safety profile of the vaccine in adults is scarce. METHODS: In 
      2017, during an outbreak of measles in Europe, Israeli travellers to high-risk 
      locations who were incompletely vaccinated, were urged to complete the two MMR 
      vaccination schedule before their travel. In this prospective cohort study, we 
      analysed adverse events (AEs) of MMR and MMRV (measles, mumps, rubella and 
      varicella) vaccines among these travellers. All participants were followed up 
      using structured questionnaires 2-4 weeks after vaccination. RESULTS: Seven 
      hundred and eighty-five adult travellers whose median age was 49.2 years were 
      vaccinated and followed up. Any AEs were reported by 25.2% of all participants; 
      11.6% reported local AEs, and 18.6% reported systemic AEs, none of which were 
      severe. In general, AEs were much more common among female travellers (19.4% of 
      males vs 30.1% of females (P < 0.001)). Local AEs, overall systemic AEs, headache 
      and arthralgia were much more common among females, whereas rates of general 
      malaise and fever were not statistically different between genders. We did not 
      observe any significant differences in the rates of total, local or systemic AEs 
      between the MMR and MMRV vaccines. Higher rates of systemic AEs were observed 
      among participants who were younger and probably immunized once with MMR compared 
      to older vaccines immunized once to measles only and to those who were never 
      immunized. CONCLUSIONS: The current study demonstrated low rates of systemic AEs 
      and no serious AEs following either MMR or MMRV administration. More AEs were 
      reported among females, and rates of AEs were similar after either MMR or MMRV.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of 
      International Society of Travel Medicine. All rights reserved. For permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Ami, Neuberger
AU  - Ami N
AD  - Bruce Rappaport Faculty of Medicine, Technion, HaAliya HaShniya St, Haifa, 
      3109601, Israel.
AD  - Division of Internal Medicine, Rambam Health Care Campus, HaAliya HaShniya St, 
      Haifa, 3109601, Israel.
AD  - Unit of Infectious Diseases, Rambam Healthcare Campus, HaAliya HaShniya St, 
      Haifa, 3109601, Israel.
FAU - Eyal, Nadir
AU  - Eyal N
AD  - Infectious Diseases Unit, Kaplan Medical Center, Derech Pasternak 1, Rehovot, 
      7610001, Israel.
AD  - Clalit Health Services, Jerusalem District, 9514622, Israel.
FAU - Asaf, Biber
AU  - Asaf B
AD  - The Center for Geographic Medicine and Tropical Diseases, Sheba Medical Center, 
      Tel Hashomer, Ramat Gan, 52621, Israel.
FAU - Chen, Avni
AU  - Chen A
AD  - The Center for Geographic Medicine and Tropical Diseases, Sheba Medical Center, 
      Tel Hashomer, Ramat Gan, 52621, Israel.
FAU - Adi, Brom
AU  - Adi B
AD  - The Center for Geographic Medicine and Tropical Diseases, Sheba Medical Center, 
      Tel Hashomer, Ramat Gan, 52621, Israel.
FAU - Drorit, Attias
AU  - Drorit A
AD  - Maoz Travel Clinic, Jerusalem, 94622, Israel.
FAU - Neta, Petersiel
AU  - Neta P
AD  - Division of Internal Medicine, Rambam Health Care Campus, HaAliya HaShniya St, 
      Haifa, 3109601, Israel.
AD  - Unit of Infectious Diseases, Rambam Healthcare Campus, HaAliya HaShniya St, 
      Haifa, 3109601, Israel.
FAU - Hajar, Dallashi
AU  - Hajar D
AD  - Bruce Rappaport Faculty of Medicine, Technion, HaAliya HaShniya St, Haifa, 
      3109601, Israel.
FAU - Stav, Rakedzon
AU  - Stav R
AD  - Division of Internal Medicine, Rambam Health Care Campus, HaAliya HaShniya St, 
      Haifa, 3109601, Israel.
FAU - Eli, Schwartz
AU  - Eli S
AD  - The Center for Geographic Medicine and Tropical Diseases, Sheba Medical Center, 
      Tel Hashomer, Ramat Gan, 52621, Israel.
AD  - Maoz Travel Clinic, Jerusalem, 94622, Israel.
AD  - Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, 69978, Israel.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Travel Med
JT  - Journal of travel medicine
JID - 9434456
RN  - 0 (Antibodies, Viral)
RN  - 0 (Chickenpox Vaccine)
RN  - 0 (Measles-Mumps-Rubella Vaccine)
RN  - 0 (Vaccines, Combined)
SB  - IM
MH  - Antibodies, Viral
MH  - *Chickenpox/prevention & control
MH  - Chickenpox Vaccine/adverse effects
MH  - Child
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Measles/prevention & control
MH  - Measles-Mumps-Rubella Vaccine/adverse effects
MH  - Middle Aged
MH  - *Mumps/chemically induced/epidemiology/prevention & control
MH  - Prospective Studies
MH  - *Rubella
MH  - Vaccines, Combined/adverse effects
OTO - NOTNLM
OT  - MMR
OT  - MMRV
OT  - adverse events
OT  - vaccine
EDAT- 2021/06/09 06:00
MHDA- 2022/04/19 06:00
CRDT- 2021/06/08 17:36
PHST- 2021/01/13 00:00 [received]
PHST- 2021/03/14 00:00 [revised]
PHST- 2021/04/27 00:00 [accepted]
PHST- 2021/06/09 06:00 [pubmed]
PHST- 2022/04/19 06:00 [medline]
PHST- 2021/06/08 17:36 [entrez]
AID - 6295126 [pii]
AID - 10.1093/jtm/taab071 [doi]
PST - ppublish
SO  - J Travel Med. 2021 Dec 29;28(8):taab071. doi: 10.1093/jtm/taab071.