PMID- 34102537
OWN - NLM
STAT- MEDLINE
DCOM- 20210913
LR  - 20210913
IS  - 2213-1582 (Electronic)
IS  - 2213-1582 (Linking)
VI  - 31
DP  - 2021
TI  - Structural and functional reorganization of contralateral hippocampus after 
      temporal lobe epilepsy surgery.
PG  - 102714
LID - S2213-1582(21)00158-3 [pii]
LID - 10.1016/j.nicl.2021.102714 [doi]
LID - 102714
AB  - OBJECTIVE: To explore the structural and functional reorganization of 
      contralateral hippocampus in patients with unilateral mesial temporal lobe 
      epilepsy (mTLE) who achieved seizure-freedom after anterior temporal lobectomy 
      (ATL). METHODS: We obtained high-resolution structural MRI and resting-state 
      functional MRI data in 28 unilateral mTLE patients and 29 healthy controls. 
      Patients were scanned before and three and 24 months after surgery while controls 
      were scanned only once. Hippocampal gray matter volume (GMV) and functional 
      connectivity (FC) were assessed. RESULTS: No obvious GMV changes were observed in 
      contralateral hippocampus before and after successful surgery. Before surgery, 
      ipsilateral hippocampus showed increased FC with ipsilateral insula (INS) and 
      temporoparietal junction (TPJ), but decreased FC with widespread bilateral 
      regions, as well as contralateral hippocampus. After successful ATL, 
      contralateral hippocampus showed: (1) decreased FC with ipsilateral INS at three 
      months follow-up, without further changes; (2) decreased FC with ipsilateral TPJ, 
      postcentral gyrus and rolandic operculum at three months, with an obvious 
      increase at 24 months follow-up; (3) increased FC with bilateral medial 
      prefrontal cortex (MPFC) and superior frontal gyrus (SFG) at three months 
      follow-up, without further changes. CONCLUSIONS: Successful ATL may not lead to 
      an obvious structural reorganization in contralateral hippocampus. Surgical 
      manipulation may lead to a transient FC reduction of contralateral hippocampus. 
      Increased FC between contralateral hippocampus and bilateral MPFC and SFG may be 
      related to postoperative functional remodeling.
CI  - Copyright (c) 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Li, Wei
AU  - Li W
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Jiang, Yuchao
AU  - Jiang Y
AD  - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for 
      Neuroinformation, Center for Information in Medicine, School of Life Science and 
      Technology, University of Electronic Science and Technology of China, Chengdu, 
      Sichuan, China.
FAU - Qin, Yingjie
AU  - Qin Y
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Zhou, Baiwan
AU  - Zhou B
AD  - Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan 
      University, Chengdu, Sichuan, China.
FAU - Lei, Du
AU  - Lei D
AD  - Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan 
      University, Chengdu, Sichuan, China.
FAU - Zhang, Heng
AU  - Zhang H
AD  - Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Lei, Ding
AU  - Lei D
AD  - Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Yao, Dezhong
AU  - Yao D
AD  - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for 
      Neuroinformation, Center for Information in Medicine, School of Life Science and 
      Technology, University of Electronic Science and Technology of China, Chengdu, 
      Sichuan, China.
FAU - Luo, Cheng
AU  - Luo C
AD  - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for 
      Neuroinformation, Center for Information in Medicine, School of Life Science and 
      Technology, University of Electronic Science and Technology of China, Chengdu, 
      Sichuan, China.
FAU - Gong, Qiyong
AU  - Gong Q
AD  - Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan 
      University, Chengdu, Sichuan, China. Electronic address: qiyonggong@hmrrc.org.cn.
FAU - Zhou, Dong
AU  - Zhou D
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China. Electronic address: zhoudong66@yahoo.de.
FAU - An, Dongmei
AU  - An D
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China. Electronic address: andongmei2010@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210602
PL  - Netherlands
TA  - Neuroimage Clin
JT  - NeuroImage. Clinical
JID - 101597070
SB  - IM
MH  - Anterior Temporal Lobectomy
MH  - *Epilepsy, Temporal Lobe/diagnostic imaging/surgery
MH  - Gray Matter
MH  - Hippocampus/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
PMC - PMC8187253
OTO - NOTNLM
OT  - Anterior temporal lobectomy
OT  - Functional connectivity
OT  - Gray matter volume
OT  - Hippocampus
OT  - Mesial temporal lobe epilepsy
OT  - Reorganization
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2021/06/09 06:00
MHDA- 2021/09/14 06:00
PMCR- 2021/06/02
CRDT- 2021/06/08 20:51
PHST- 2021/02/06 00:00 [received]
PHST- 2021/05/27 00:00 [revised]
PHST- 2021/05/28 00:00 [accepted]
PHST- 2021/06/09 06:00 [pubmed]
PHST- 2021/09/14 06:00 [medline]
PHST- 2021/06/08 20:51 [entrez]
PHST- 2021/06/02 00:00 [pmc-release]
AID - S2213-1582(21)00158-3 [pii]
AID - 102714 [pii]
AID - 10.1016/j.nicl.2021.102714 [doi]
PST - ppublish
SO  - Neuroimage Clin. 2021;31:102714. doi: 10.1016/j.nicl.2021.102714. Epub 2021 Jun 
      2.