PMID- 34102579
OWN - NLM
STAT- MEDLINE
DCOM- 20211012
LR  - 20211204
IS  - 1568-7856 (Electronic)
IS  - 1568-7856 (Linking)
VI  - 104
DP  - 2021 Aug
TI  - mTOR pathway and DNA damage response: A therapeutic strategy in cancer therapy.
PG  - 103142
LID - S1568-7864(21)00098-7 [pii]
LID - 10.1016/j.dnarep.2021.103142 [doi]
AB  - The mammalian target of rapamycin (mTOR) is a conserved serine/threonine-protein 
      kinase, comprising two subunit protein complexes: mTORC1 and mTORC2. In response 
      to insult and cancer, the mTOR pathway plays a crucial role in regulating growth, 
      metabolism, cell survival, and protein synthesis. Key subunits of mTORC1/2 
      catalyze the phosphorylation of various molecules, including eukaryotic 
      translation initiation factor 4E binding protein 1 (4E-BP1), ribosomal protein S6 
      kinase beta-1 (S6K1). The DNA damage response (DDR) maintains genomic stability and 
      provides an opportunity for treating tumors with defects caused by DNA damaging 
      agents. Many mTOR inhibitors are utilized for the treatment of cancers. However, 
      several clinical trials are still assessing the efficacy of mTOR inhibitors. This 
      paper discusses the role of the mTOR signaling pathway and its regulators in 
      developing cancer. In the following, we will review the interaction between DDR 
      and mTOR signaling and the innovative therapies applied in preclinical and 
      clinical trials for treating cancers.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Danesh Pazhooh, Romina
AU  - Danesh Pazhooh R
AD  - Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran. Electronic 
      address: romina.danesh.p@gmail.com.
FAU - Rahnamay Farnood, Parnia
AU  - Rahnamay Farnood P
AD  - Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran. Electronic 
      address: parniarahnama@ymail.com.
FAU - Asemi, Zatollah
AU  - Asemi Z
AD  - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute 
      for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. 
      Electronic address: Asemi_r@yahoo.com.
FAU - Mirsafaei, Liaosadat
AU  - Mirsafaei L
AD  - Department of Cardiology, Ramsar Campus, Mazandaran University of Medical 
      Sciences, Sari, Iran. Electronic address: Liaosadat.mirsafaei@gmail.com.
FAU - Yousefi, Bahman
AU  - Yousefi B
AD  - Molecular Medicine Research Center, Tabriz University of Medical Sciences, 
      Tabriz, Iran; Department of Biochemistry, Faculty of Medicine, Tabriz University 
      of Medical Sciences, Tabriz, Iran. Electronic address: bahmanusefi@gmail.com.
FAU - Mirzaei, Hamed
AU  - Mirzaei H
AD  - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute 
      for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. 
      Electronic address: h.mirzaei2002@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210603
PL  - Netherlands
TA  - DNA Repair (Amst)
JT  - DNA repair
JID - 101139138
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (EIF4EBP1 protein, human)
RN  - 9007-49-2 (DNA)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (ribosomal protein S6 kinase, 70kD, polypeptide 2)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/metabolism
MH  - Animals
MH  - Cell Cycle Proteins/metabolism
MH  - DNA/metabolism
MH  - *DNA Damage
MH  - *DNA Repair
MH  - Humans
MH  - Neoplasms/*drug therapy/genetics/metabolism
MH  - Phosphorylation
MH  - Protein Processing, Post-Translational
MH  - Ribosomal Protein S6 Kinases, 70-kDa/metabolism
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
OTO - NOTNLM
OT  - Cancer
OT  - DNA damage
OT  - DNA repair
OT  - Therapy
OT  - mTOR
EDAT- 2021/06/09 06:00
MHDA- 2021/10/13 06:00
CRDT- 2021/06/08 20:55
PHST- 2021/04/28 00:00 [received]
PHST- 2021/05/26 00:00 [revised]
PHST- 2021/05/31 00:00 [accepted]
PHST- 2021/06/09 06:00 [pubmed]
PHST- 2021/10/13 06:00 [medline]
PHST- 2021/06/08 20:55 [entrez]
AID - S1568-7864(21)00098-7 [pii]
AID - 10.1016/j.dnarep.2021.103142 [doi]
PST - ppublish
SO  - DNA Repair (Amst). 2021 Aug;104:103142. doi: 10.1016/j.dnarep.2021.103142. Epub 
      2021 Jun 3.