PMID- 34103902
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220423
IS  - 1177-889X (Print)
IS  - 1177-889X (Electronic)
IS  - 1177-889X (Linking)
VI  - 15
DP  - 2021
TI  - Patient Preferences for Treating "OFF" Episodes in Parkinson's Disease: A 
      Discrete Choice Experiment.
PG  - 1187-1196
LID - 10.2147/PPA.S301644 [doi]
AB  - INTRODUCTION: Several on-demand treatments are available for management of "OFF" 
      episodes in patients with Parkinson's disease (PD). We evaluated patients' 
      preferences for features of theoretical on-demand treatment options. METHODS: In 
      a discrete choice experiment, US adults with self-reported PD of >/=5 years, or <5 
      years with "OFF" episodes, taking oral carbidopa/levodopa, selected between pairs 
      of theoretical on-demand treatments that varied by mode of administration (with 
      and without mode-specific adverse events [AEs]), time to FULL "ON," duration of 
      "ON," and out-of-pocket cost for a 30-day supply. Data were analyzed with a 
      random parameters logit model; results were used to calculate relative importance 
      of treatment attributes, preference shares, and willingness to pay. RESULTS: 
      Among 300 respondents, 98% had "OFF" episodes. Across the range of attribute 
      levels included in the survey, avoiding $90 cost was most important to 
      respondents, followed by a preferable mode of administration with associated AEs 
      and decreasing time to FULL "ON." Duration of "ON" was relatively less important. 
      On average, respondents preferred a theoretical dissolvable sublingual film 
      versus other theoretical treatments with alternative modes of administration. 
      Respondents were willing to pay $28-$52 US dollars to switch from least- to 
      more-preferred mode of administration with associated AEs, $58 to reach FULL "ON" 
      in 15 versus 60 min, and $9 to increase duration of FULL "ON" from 1 to 2 h. 
      CONCLUSION: Respondents with PD valued lower out-of-pocket cost and a sublingual 
      mode of administration with its associated AEs when choosing an on-demand 
      treatment for "OFF" episodes.
CI  - (c) 2021 Thach et al.
FAU - Thach, Andrew
AU  - Thach A
AD  - Health Economics and Outcomes Research, Sunovion Pharmaceuticals Inc., 
      Marlborough, MA, USA.
FAU - Sutphin, Jessie
AU  - Sutphin J
AD  - Health Preference Assessment, RTI Health Solutions, Research Triangle Park, NC, 
      USA.
FAU - Coulter, Joshua
AU  - Coulter J
AD  - Health Preference Assessment, RTI Health Solutions, Research Triangle Park, NC, 
      USA.
FAU - Leach, Colton
AU  - Leach C
AD  - Health Preference Assessment, RTI Health Solutions, Research Triangle Park, NC, 
      USA.
FAU - Pappert, Eric
AU  - Pappert E
AD  - Medical Affairs, Sunovion Pharmaceuticals Inc., Marlborough, MA, USA.
FAU - Mansfield, Carol
AU  - Mansfield C
AUID- ORCID: 0000-0002-3144-8938
AD  - Health Preference Assessment, RTI Health Solutions, Research Triangle Park, NC, 
      USA.
LA  - eng
PT  - Journal Article
DEP - 20210601
PL  - New Zealand
TA  - Patient Prefer Adherence
JT  - Patient preference and adherence
JID - 101475748
PMC - PMC8179791
OTO - NOTNLM
OT  - Parkinson's disease
OT  - apomorphine sublingual film
OT  - discrete choice experiment
OT  - patient preference
OT  - "OFF" episode
COIS- AT and EP are salaried employees of Sunovion Pharmaceuticals Inc. JS was a 
      salaried employee of RTI Health Solutions when the study was conducted and is now 
      affiliated with Duke Clinical Research Institute, Duke University, Durham, NC, 
      USA. JC, CL, and CM are salaried employees of RTI Health Solutions. The authors 
      report no other conflicts of interest in this work.
EDAT- 2021/06/10 06:00
MHDA- 2021/06/10 06:01
PMCR- 2021/06/01
CRDT- 2021/06/09 06:40
PHST- 2021/02/04 00:00 [received]
PHST- 2021/05/05 00:00 [accepted]
PHST- 2021/06/09 06:40 [entrez]
PHST- 2021/06/10 06:00 [pubmed]
PHST- 2021/06/10 06:01 [medline]
PHST- 2021/06/01 00:00 [pmc-release]
AID - 301644 [pii]
AID - 10.2147/PPA.S301644 [doi]
PST - epublish
SO  - Patient Prefer Adherence. 2021 Jun 1;15:1187-1196. doi: 10.2147/PPA.S301644. 
      eCollection 2021.