PMID- 34104303
OWN - NLM
STAT- MEDLINE
DCOM- 20210615
LR  - 20210615
IS  - 1937-8688 (Electronic)
VI  - 38
DP  - 2021
TI  - [Chemotherapy for breast cancer during pregnancy: about a case].
PG  - 255
LID - 10.11604/pamj.2021.38.255.18879 [doi]
LID - 255
AB  - The management of breast cancer during pregnancy is a challenge for physicians 
      due to mother s desire to carry the pregnancy to term despite the need for 
      chemotherapy. This study reports the case of a 37-year-old multiparous woman at 
      20 weeks and 4 days of amenorrhea (WA). She was hospitalized for dyspnoea (stage 
      IV according to New York Heart Association (NYHA) classification). The patient 
      had a syndrome of heavy left pleural effusion and bilateral mastitis. The 
      diagnosis of metastatic breast cancer was retained based on cytological 
      examination of pleural fluid and breast cytoponction revealing galactophoric 
      carcinoma. The patient underwent pleural drainage with improvement of dyspnea but 
      pleural fluid continued. After multidisciplinary consultation (MC), specific 
      treatment of cancer was necessary. Five cycles of epirubicin- 
      cyclophosphamide-5-FU-based chemotherapy was performed after the couple provided 
      consent. Pleural fluid diminished significantly after the second cycle of 
      treatment. After consultation with the obstetrician, chemotherapy was interrupted 
      one month before the 37(th) week of amenorrhea. Pregnancy evolved favorable, 
      vaginal birth was managed following rupture of membranes at term with good 
      neonatal adaptation. After one-year follow-up, the mother was still on 
      chemotherapy and the baby was in good health. Several parameters should be 
      considered before the administration of antineoplastic agents, hence the role of 
      early fetal and maternal monitoring. Multidisciplinary approach is recommended to 
      support therapeutic decision and follow-up.
CI  - Copyright: Henintsoa Murielle Rakotomalala et al.
FAU - Rakotomalala, Henintsoa Murielle
AU  - Rakotomalala HM
AD  - Faculte de Medecine d'Antananarivo, Antananarivo, Madagascar.
FAU - Ramahandrisoa, Andriatsihoarana Voahary Nasandratriniavo
AU  - Ramahandrisoa AVN
AD  - Service d'Oncologie, Centre Hospitalier Universitaire Joseph Ravoahangy 
      Andrianavalona, Antananarivo, Madagascar.
FAU - Razakanaivo, Malala
AU  - Razakanaivo M
AD  - Service d'Oncologie, Centre Hospitalier Universitaire Joseph Ravoahangy 
      Andrianavalona, Antananarivo, Madagascar.
FAU - Andrianandrasana, Ny Ony
AU  - Andrianandrasana NO
AD  - Service d'Oncologie, Centre Hospitalier Universitaire Joseph Ravoahangy 
      Andrianavalona, Antananarivo, Madagascar.
FAU - Rafaramino, Florine
AU  - Rafaramino F
AD  - Faculte de Medecine d'Antananarivo, Antananarivo, Madagascar.
LA  - fre
PT  - Case Reports
TT  - Chimiotherapie du cancer du sein au cours de la grossesse: a propos d un cas.
DEP - 20210311
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
RN  - 3Z8479ZZ5X (Epirubicin)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Adult
MH  - Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
MH  - Breast Neoplasms/diagnosis/*drug therapy/pathology
MH  - Cyclophosphamide/administration & dosage
MH  - Epirubicin/administration & dosage
MH  - Female
MH  - Fluorouracil/administration & dosage
MH  - Follow-Up Studies
MH  - Humans
MH  - Pleural Effusion/diagnosis
MH  - Pregnancy
MH  - Pregnancy Complications, Neoplastic/diagnosis/*drug therapy/pathology
MH  - *Pregnancy Outcome
PMC - PMC8164436
OTO - NOTNLM
OT  - Breast cancer
OT  - case report
OT  - chemotherapy
OT  - multidisciplinary consultation
OT  - pregnancy
COIS- Les auteurs ne declarent aucun conflit d interets.
EDAT- 2021/06/10 06:00
MHDA- 2021/06/16 06:00
PMCR- 2021/03/11
CRDT- 2021/06/09 06:45
PHST- 2019/05/05 00:00 [received]
PHST- 2020/01/27 00:00 [accepted]
PHST- 2021/06/09 06:45 [entrez]
PHST- 2021/06/10 06:00 [pubmed]
PHST- 2021/06/16 06:00 [medline]
PHST- 2021/03/11 00:00 [pmc-release]
AID - PAMJ-38-255 [pii]
AID - 10.11604/pamj.2021.38.255.18879 [doi]
PST - epublish
SO  - Pan Afr Med J. 2021 Mar 11;38:255. doi: 10.11604/pamj.2021.38.255.18879. 
      eCollection 2021.