PMID- 34105081 OWN - NLM STAT- MEDLINE DCOM- 20211102 LR - 20211102 IS - 1875-8312 (Electronic) IS - 1569-5794 (Linking) VI - 37 IP - 11 DP - 2021 Nov TI - Impairment of left atrial function in pediatric patients with repaired tetralogy of Fallot: a cardiovascular magnetic resonance imaging study. PG - 3255-3267 LID - 10.1007/s10554-021-02302-3 [doi] AB - We aimed to assess left atrial (LA) strain before LA dilatation in patients with repaired tetralogy of Fallot (rTOF) compared with healthy controls. We also determined the effects of right atrial (RA) dilatation on LA performance using cardiovascular magnetic resonance-feature tracking (CMR-FT). Forty-nine pediatric patients with rTOF and 36 age- and sex-matched healthy controls were prospectively recruited between June 2017 and August 2019. Balanced steady-state free precession (2D b-SSFP) cine, 2D late gadolinium enhancement (LGE) and phase-contrast (PC) sequences were acquired on 1.5 and 3.0 Tesla scanners. Both ventricular and atrial volumes and ejection fraction were measured. Left ventricular (LV) strain and diastolic strain rates were evaluated between the rTOF patient and control groups. LA reservoir (Es), conduit (Ee), and booster strain (Ea) were determined at LV end-systole, LV diastasis, and pre-LA systole, respectively. The first derivatives of the respective strains yielded corresponding peak strain rates. Statistical analysis was performed using the t-test and Mann-Whitney test for parametric and non-parametric variables, respectively. Correlations were assessed using Pearson's correlation coefficient for normally distributed variables and Spearman's correlation coefficient for non-parametric data. Intra-observer and inter-observer variabilities of LA strain and strain rate measurements were determined from ten randomly selected rTOF patients and ten control subjects. LA strain was significantly lower in patients with rTOF compared with controls (Es, P < 0.001; Ee, P = 0.002; Ea, P < 0.001). The correlations between LA strain and RA stroke volume indices (SVi) and RA ejection fraction (EF) were moderate (Es and SVi, r = 0.538, P < 0.001; Es and RA EF, r = 0.493, P < 0.001; Ee and SVi, r = 0.532, P < 0.001; Ee and RA EF, r = 0.466, P < 0.001). LA strain and strain rates had good reproducibility in intra-observer and inter-observer analyses. LA strain and strain rates decreased in pediatric patients with rTOF compared with controls before LA enlargement. A dysfunction in LA performance might precede LV dysfunction in patients with rTOF, even in the early stages after repair. CI - (c) 2021. The Author(s), under exclusive licence to Springer Nature B.V. FAU - Hu, Liwei AU - Hu L AD - Diagnostic Imaging Center, Shanghai Children's Medical Center Affiliated With Shanghai Jiao Tong University School of Medicine, 1678 Dong Fang Road, Shanghai, 200127, People's Republic of China. FAU - Ouyang, Rongzhen AU - Ouyang R AD - Diagnostic Imaging Center, Shanghai Children's Medical Center Affiliated With Shanghai Jiao Tong University School of Medicine, 1678 Dong Fang Road, Shanghai, 200127, People's Republic of China. FAU - Liu, Xinlong AU - Liu X AD - Department of Cardiovascular and Thoracic Surgery, Shanghai Children's Medical Center Affiliated With Shanghai, Jiao Tong University School of Medicine, No. 1678 Dong Fang Road, Shanghai, 200127, China. FAU - Shuang, Leng AU - Shuang L AD - National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore. AD - Duke-NUS Medical School, National University of Singapore, 8 College Rd., Singapore, 169857, Singapore. FAU - Xiaodan, Zhao AU - Xiaodan Z AD - National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore. AD - Duke-NUS Medical School, National University of Singapore, 8 College Rd., Singapore, 169857, Singapore. FAU - Guo, Chen AU - Guo C AD - Diagnostic Imaging Center, Shanghai Children's Medical Center Affiliated With Shanghai Jiao Tong University School of Medicine, 1678 Dong Fang Road, Shanghai, 200127, People's Republic of China. FAU - Peng, Yafeng AU - Peng Y AD - Diagnostic Imaging Center, Shanghai Children's Medical Center Affiliated With Shanghai Jiao Tong University School of Medicine, 1678 Dong Fang Road, Shanghai, 200127, People's Republic of China. FAU - Xie, Weihui AU - Xie W AD - Diagnostic Imaging Center, Shanghai Children's Medical Center Affiliated With Shanghai Jiao Tong University School of Medicine, 1678 Dong Fang Road, Shanghai, 200127, People's Republic of China. FAU - Han, Tongtong AU - Han T AD - Circle Cardiovascular Imaging, 250, 815 8th Ave SW, Calgary, Canada. FAU - Liang, Zhong AU - Liang Z AD - National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore. zhong.liang@nhcs.com.sg. AD - Duke-NUS Medical School, National University of Singapore, 8 College Rd., Singapore, 169857, Singapore. zhong.liang@nhcs.com.sg. FAU - Zhong, Yumin AU - Zhong Y AUID- ORCID: 0000-0002-0164-8752 AD - Diagnostic Imaging Center, Shanghai Children's Medical Center Affiliated With Shanghai Jiao Tong University School of Medicine, 1678 Dong Fang Road, Shanghai, 200127, People's Republic of China. zyumin2002@163.com. AD - Department of Cardiovascular and Thoracic Surgery, Shanghai Children's Medical Center Affiliated With Shanghai, Jiao Tong University School of Medicine, No. 1678 Dong Fang Road, Shanghai, 200127, China. zyumin2002@163.com. LA - eng GR - 2018YFB1107100/National Key R&D Program of China/ GR - 17411965400/Science and Technology Commission of Shanghai Municipality/ GR - 17DZ2253100/Science and Technology Commission of Shanghai Municipality/ GR - 201740095/Shanghai Municipal Population and Family Planning Commission/ PT - Journal Article DEP - 20210608 PL - United States TA - Int J Cardiovasc Imaging JT - The international journal of cardiovascular imaging JID - 100969716 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Atrial Function, Left MH - Child MH - Contrast Media MH - Gadolinium MH - Humans MH - Magnetic Resonance Imaging MH - Magnetic Resonance Imaging, Cine MH - Predictive Value of Tests MH - Reproducibility of Results MH - Retrospective Studies MH - *Tetralogy of Fallot/diagnostic imaging/surgery OTO - NOTNLM OT - Cardiovascular magnetic resonance OT - Feature tracking OT - Left atrial strain OT - Remodeling OT - Repaired TOF EDAT- 2021/06/10 06:00 MHDA- 2021/11/03 06:00 CRDT- 2021/06/09 06:58 PHST- 2021/02/21 00:00 [received] PHST- 2021/05/25 00:00 [accepted] PHST- 2021/06/10 06:00 [pubmed] PHST- 2021/11/03 06:00 [medline] PHST- 2021/06/09 06:58 [entrez] AID - 10.1007/s10554-021-02302-3 [pii] AID - 10.1007/s10554-021-02302-3 [doi] PST - ppublish SO - Int J Cardiovasc Imaging. 2021 Nov;37(11):3255-3267. doi: 10.1007/s10554-021-02302-3. Epub 2021 Jun 8.