PMID- 34105563
OWN - NLM
STAT- MEDLINE
DCOM- 20211130
LR  - 20221207
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 12
IP  - 14
DP  - 2021 Jul 21
TI  - Lactobacillus plantarum HAC01 ameliorates type 2 diabetes in high-fat diet and 
      streptozotocin-induced diabetic mice in association with modulating the gut 
      microbiota.
PG  - 6363-6373
LID - 10.1039/d1fo00698c [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a serious metabolic disorder that occurs 
      worldwide; however, this condition can be managed with probiotics. We assessed 
      the potential therapeutic effects of Lactobacillus plantarum HAC01 on 
      hyperglycemia and T2DM and determined their potential mechanisms using mice with 
      high-fat diet (HFD) and streptozotocin (STZ)-induced diabetes. The diabetic model 
      was established with an HFD and 50 mg kg(-1) STZ. L. plantarum HAC01 was then 
      administered for 10 weeks. Body weight, food and water intake, biochemical 
      parameters, and homeostasis model assessment for insulin resistance (HOMA-IR) 
      were measured. Oral glucose tolerance test and histological analysis were 
      performed, and the glucose metabolism-related gene expression and signaling 
      pathways in the liver were determined. Fecal microbiota and serum short-chain 
      fatty acids (SCFAs) were also analyzed. L. plantarum HAC01 significantly lowered 
      blood glucose and HbA1c levels and improved glucose tolerance and HOMA-IR. 
      Additionally, it increased the insulin-positive beta-cell area in islets and 
      decreased the mRNA expression levels of phosphoenolpyruvate carboxykinase and 
      glucose 6-phosphatase, which are associated with gluconeogenesis. L. plantarum 
      HAC01 also increased the phosphorylation of AMPK and Akt, which are involved in 
      glucose metabolism in the liver. Notably, L. plantarum HAC01 increased the 
      Akkermansiaceae family and increased SCFAs in serum. L. plantarum HAC01 could 
      alleviate hyperglycemia and T2DM by regulating glucose metabolism in the liver, 
      protecting the islet beta-cell mass, and restoring the gut microbiota and SCFAs. L. 
      plantarum HAC01 may thus be an effective therapeutic agent for T2DM.
FAU - Lee, Young-Sil
AU  - Lee YS
AD  - AtoGen Co., Ltd, Daejeon, 34015, Korea. jhkang@atogen.co.kr.
FAU - Lee, Daeyoung
AU  - Lee D
FAU - Park, Gun-Seok
AU  - Park GS
FAU - Ko, Seung-Hyun
AU  - Ko SH
FAU - Park, Juyi
AU  - Park J
FAU - Lee, You-Kyung
AU  - Lee YK
FAU - Kang, Jihee
AU  - Kang J
LA  - eng
PT  - Journal Article
DEP - 20210609
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Volatile)
RN  - 0 (Glycated Hemoglobin A)
RN  - 5W494URQ81 (Streptozocin)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Experimental/*drug therapy/metabolism
MH  - Diabetes Mellitus, Type 2/*drug therapy/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Fatty Acids, Volatile/metabolism
MH  - Feces/microbiology
MH  - Gastrointestinal Microbiome/*drug effects
MH  - Gluconeogenesis/drug effects
MH  - Glycated Hemoglobin/metabolism
MH  - Hyperglycemia/drug therapy/metabolism
MH  - Insulin Resistance
MH  - *Lactobacillus plantarum
MH  - Liver/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Probiotics/*administration & dosage
MH  - Streptozocin/adverse effects
EDAT- 2021/06/10 06:00
MHDA- 2021/12/01 06:00
CRDT- 2021/06/09 08:48
PHST- 2021/06/10 06:00 [pubmed]
PHST- 2021/12/01 06:00 [medline]
PHST- 2021/06/09 08:48 [entrez]
AID - 10.1039/d1fo00698c [doi]
PST - ppublish
SO  - Food Funct. 2021 Jul 21;12(14):6363-6373. doi: 10.1039/d1fo00698c. Epub 2021 Jun 
      9.