PMID- 34105694
OWN - NLM
STAT- MEDLINE
DCOM- 20210610
LR  - 20210629
IS  - 1678-7765 (Electronic)
IS  - 1678-7757 (Print)
IS  - 1678-7757 (Linking)
VI  - 29
DP  - 2021
TI  - Effects of acute mental stress on conditioned pain modulation in 
      temporomandibular disorders patients and healthy individuals.
PG  - e20200952
LID - S1678-77572021000100426 [pii]
LID - 10.1590/1678-7757-2020-0952 [doi]
LID - e20200952
AB  - BACKGROUND: Stress is a contributing factor to painful temporomandibular 
      disorders (TMD). Nevertheless, the underpinnings of this relationship are not 
      fully understood. OBJECTIVE: To investigate the effects of acute mental stress on 
      conditioned pain modulation (CPM) in TMD patients compared with healthy 
      individuals. METHODOLOGY: Twenty women with chronic myofascial TMD diagnosed 
      according to the RDC/TMD and 20 age-matched healthy women had the CPM assessed 
      before and after a stressful task using the Paced Auditory Serial Addition Task 
      (PASAT) in a single session. Subjective stress response was assessed with the aid 
      of visual analog scale (VAS). Pressure pain threshold (PPT) on masseter muscle 
      was the test stimulus (TS) and immersion of the participant's hand on hot water 
      was the conditioning stimulus (CS) - CPM-sequential paradigm. RESULTS: Healthy 
      individuals reported PASAT are more stressful when compared with TMD patients and 
      the stress task did not affect the CPM in neither group. Nonetheless, a negative 
      correlation was observed between change in CPM and change in TS from baseline to 
      post-stress session, which indicates that the greater the increase in PPT after 
      the stress task, the greater was the decrease in CPM magnitude. The correlation 
      was strong for healthy controls (r=- 0.72, p<0.001) and moderate for TMD patients 
      (r=- 0.44, p=0.047). CONCLUSIONS: The correlation between the change in CPM and 
      the TS change following the stress task may possibly indicate an overlapping 
      pathway between stress-induced analgesia/hyperalgesia and descending pain 
      inhibition.
FAU - Ferreira, Dyna Mara Araujo Oliveira
AU  - Ferreira DMAO
AUID- ORCID: 0000-0001-5166-8519
AD  - Universidade de Sao Paulo, Faculdade de Odontologia de Bauru, Departamento de 
      Protese e Periodontia, Bauru, Brasil.
FAU - Costa, Yuri Martins
AU  - Costa YM
AUID- ORCID: 0000-0002-7658-5020
AD  - Universidade de Campinas, Faculdade de Odontologia de Piracicaba, Departamento de 
      Biociencias, Piracicaba, Brasil.
FAU - Bonjardim, Leonardo Rigoldi
AU  - Bonjardim LR
AUID- ORCID: 0000-0002-0080-7678
AD  - Universidade de Sao Paulo, Faculdade de Odontologia de Bauru, Departamento de 
      Ciencias Biologicas, Bauru, Brasil.
FAU - Conti, Paulo Cesar Rodrigues
AU  - Conti PCR
AUID- ORCID: 0000-0003-0413-4658
AD  - Universidade de Sao Paulo, Faculdade de Odontologia de Bauru, Departamento de 
      Protese e Periodontia, Bauru, Brasil.
LA  - eng
PT  - Journal Article
DEP - 20210604
PL  - Brazil
TA  - J Appl Oral Sci
JT  - Journal of applied oral science : revista FOB
JID - 101189774
SB  - IM
MH  - Female
MH  - Humans
MH  - Pain
MH  - Pain Measurement
MH  - *Pain Threshold
MH  - Stress, Psychological
MH  - *Temporomandibular Joint Disorders
PMC - PMC8232930
COIS- Declaration of competing interest The authors declare no conflict of interest.
EDAT- 2021/06/10 06:00
MHDA- 2021/06/11 06:00
PMCR- 2021/06/04
CRDT- 2021/06/09 08:50
PHST- 2020/11/04 00:00 [received]
PHST- 2021/02/18 00:00 [accepted]
PHST- 2021/06/09 08:50 [entrez]
PHST- 2021/06/10 06:00 [pubmed]
PHST- 2021/06/11 06:00 [medline]
PHST- 2021/06/04 00:00 [pmc-release]
AID - S1678-77572021000100426 [pii]
AID - 10.1590/1678-7757-2020-0952 [doi]
PST - epublish
SO  - J Appl Oral Sci. 2021 Jun 4;29:e20200952. doi: 10.1590/1678-7757-2020-0952. 
      eCollection 2021.