PMID- 34105877
OWN - NLM
STAT- MEDLINE
DCOM- 20220215
LR  - 20231107
IS  - 1752-8062 (Electronic)
IS  - 1752-8054 (Print)
IS  - 1752-8054 (Linking)
VI  - 14
IP  - 5
DP  - 2021 Sep
TI  - HLA-associated adverse drug reactions - scoping review.
PG  - 1648-1658
LID - 10.1111/cts.13062 [doi]
AB  - Alleles of the human leukocyte antigen (HLA) system have been associated with the 
      occurrence of idiosyncratic adverse drug reactions (ADRs). Accordingly, it is 
      assumed that pre-emptive testing for the presence of certain HLA alleles 
      (HLA-typing) could prevent these ADRs in carriers. In order to perceive the 
      current evidence for HLA-associated ADRs, we conducted a scoping review according 
      to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 
      (PRISMA). The literature search on PubMed and on Embase was carried out on the 
      July 8 and 9, 2020, respectively. To be included in the scoping review, the 
      studies had to investigate an association of any HLA-associated ADR with any 
      small molecule approved and available on the Swiss market. We considered English 
      and German primary literature published since 2002. A total of 149 studies were 
      included, whereof most were retrospective, whereas one was a prospective 
      randomized controlled trial. The majority of the studies (n = 33) described the 
      association of HLA-B*15:02 with carbamazepine. It was not possible to directly 
      compare the studies, as they were too heterogeneous in terms of the ADR 
      definition, the HLA alleles, the number of participants, and the study types. 
      Therefore, we summarized the results in a descriptive manner. Even if an 
      interpretation of the outcomes remains open, the descriptive overview revealed 
      the prevailing complexity and uncertainty in the field. For the future, 
      consistent definitions on the different phenotypes need to be established and 
      applied and the reporting of association studies should follow a harmonized 
      structure.
CI  - (c) 2021 The Authors. Clinical and Translational Science published by Wiley 
      Periodicals LLC on behalf of the American Society for Clinical Pharmacology and 
      Therapeutics.
FAU - Jeiziner, Chiara
AU  - Jeiziner C
AD  - Pharmaceutical Care Research Group, Department of Pharmaceutical Sciences, 
      University of Basel, Basel, Switzerland.
FAU - Wernli, Ursina
AU  - Wernli U
AD  - Pharmaceutical Care Research Group, Department of Pharmaceutical Sciences, 
      University of Basel, Basel, Switzerland.
FAU - Suter, Katja
AU  - Suter K
AD  - European Center of Pharmaceutical Medicine, Faculty of Medicine, University of 
      Basel, Basel, Switzerland.
FAU - Hersberger, Kurt E
AU  - Hersberger KE
AD  - Pharmaceutical Care Research Group, Department of Pharmaceutical Sciences, 
      University of Basel, Basel, Switzerland.
FAU - Meyer Zu Schwabedissen, Henriette E
AU  - Meyer Zu Schwabedissen HE
AD  - Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, 
      Switzerland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210609
PL  - United States
TA  - Clin Transl Sci
JT  - Clinical and translational science
JID - 101474067
RN  - 0 (HLA Antigens)
RN  - 33CM23913M (Carbamazepine)
SB  - IM
MH  - Alleles
MH  - Carbamazepine/adverse effects
MH  - Drug-Related Side Effects and Adverse Reactions/genetics/*immunology/prevention & 
      control
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics/immunology
MH  - Heterozygote
MH  - Histocompatibility Testing
MH  - Humans
PMC - PMC8504845
COIS- All authors declared no competing interests for this work.
EDAT- 2021/06/10 06:00
MHDA- 2022/02/16 06:00
PMCR- 2021/09/01
CRDT- 2021/06/09 08:57
PHST- 2021/04/14 00:00 [revised]
PHST- 2021/02/24 00:00 [received]
PHST- 2021/04/16 00:00 [accepted]
PHST- 2021/06/10 06:00 [pubmed]
PHST- 2022/02/16 06:00 [medline]
PHST- 2021/06/09 08:57 [entrez]
PHST- 2021/09/01 00:00 [pmc-release]
AID - CTS13062 [pii]
AID - 10.1111/cts.13062 [doi]
PST - ppublish
SO  - Clin Transl Sci. 2021 Sep;14(5):1648-1658. doi: 10.1111/cts.13062. Epub 2021 Jun 
      9.