PMID- 34105902
OWN - NLM
STAT- MEDLINE
DCOM- 20210811
LR  - 20240403
IS  - 2162-3279 (Electronic)
VI  - 11
IP  - 7
DP  - 2021 Jul
TI  - Resting-state functional connectivity in patients with a complex PTSD or complex 
      dissociative disorder before and after inpatient trauma treatment.
PG  - e02200
LID - 10.1002/brb3.2200 [doi]
LID - e02200
AB  - INTRODUCTION: Recent research suggests that traumatized patients are 
      characterized by disrupted resting-state functional connectivity. We examined 
      whether neural networks involved in resting-state change over the course of a 
      phase-oriented inpatient treatment for complex traumatized and dissociative 
      disorder patients. We also investigated associations between these network 
      alterations and clinical symptoms and emotion regulation skills. METHODS: Pre- 
      and post-treatment, electroencephalography (EEG) was recorded during 
      resting-state in patients (n = 23) with a complex dissociative disorder (CDD) or 
      complex posttraumatic stress disorder (cPTSD). Patients also completed clinical 
      and emotion regulation questionnaires. To reduce variance in the collected data, 
      patients were exclusively tested as one prototypical dissociative part referred 
      to as Apparently Normal Part (ANP). Functional network connectivity was examined 
      and compared with a matched healthy control group (n = 37), also measured twice. 
      RESULTS: Prior to treatment and compared with controls, patients had a 
      significantly lower functional connectivity strength within eyes-open and 
      eyes-closed resting-state networks in the theta and alpha frequency band. 
      Following treatment, functional connectivity strength within these networks was 
      comparable to the control group and comprised areas belonging to the default mode 
      network (DMN) and prefrontal as well as anterior cingulate control regions. 
      Treatment-related network normalizations in the theta frequency band were 
      associated with a self-reported increase in the use of cognitive reappraisal 
      strategies and reduction in emotion regulation difficulties. CONCLUSION: 
      Phase-oriented trauma treatment can strengthen resting-state network connectivity 
      and can increase the capacity of complex traumatized and dissociative patients as 
      ANP to handle emotional challenges effectively.
CI  - (c) 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
FAU - Schlumpf, Yolanda R
AU  - Schlumpf YR
AUID- ORCID: 0000-0002-5754-2113
AD  - Division of Neuropsychology, Department of Psychology, University of Zurich, 
      Zurich, Switzerland.
AD  - Clienia Littenheid AG, Hospital for Psychiatry and Psychotherapy, Littenheid, 
      Switzerland.
FAU - Nijenhuis, Ellert R S
AU  - Nijenhuis ERS
AD  - Clienia Littenheid AG, Hospital for Psychiatry and Psychotherapy, Littenheid, 
      Switzerland.
FAU - Klein, Carina
AU  - Klein C
AUID- ORCID: 0000-0003-0159-1079
AD  - Division of Neuropsychology, Department of Psychology, University of Zurich, 
      Zurich, Switzerland.
FAU - Jancke, Lutz
AU  - Jancke L
AD  - Division of Neuropsychology, Department of Psychology, University of Zurich, 
      Zurich, Switzerland.
AD  - Research Unit for Plasticity and Learning of the Healthy Aging Brain, University 
      of Zurich, Zurich, Switzerland.
FAU - Bachmann, Silke
AU  - Bachmann S
AD  - Department of Psychiatry, Psychotherapy, and Psychosomatics, University Hospitals 
      and University of Halle (Saale), Halle, Germany.
AD  - Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland.
LA  - eng
SI  - ClinicalTrials.gov/NCT02459340
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210609
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
SB  - IM
MH  - Brain
MH  - Brain Mapping
MH  - Dissociative Disorders/therapy
MH  - Humans
MH  - Inpatients
MH  - Magnetic Resonance Imaging
MH  - Neural Pathways/diagnostic imaging
MH  - *Stress Disorders, Post-Traumatic/therapy
PMC - PMC8323038
OTO - NOTNLM
OT  - clinical observation study
OT  - complex trauma
OT  - dissociation
OT  - electroencephalography
OT  - functional brain network
OT  - resting-state
COIS- All authors declare no conflicts of interest.
EDAT- 2021/06/10 06:00
MHDA- 2021/08/12 06:00
PMCR- 2021/06/09
CRDT- 2021/06/09 08:59
PHST- 2021/04/30 00:00 [revised]
PHST- 2020/10/26 00:00 [received]
PHST- 2021/05/09 00:00 [accepted]
PHST- 2021/06/10 06:00 [pubmed]
PHST- 2021/08/12 06:00 [medline]
PHST- 2021/06/09 08:59 [entrez]
PHST- 2021/06/09 00:00 [pmc-release]
AID - BRB32200 [pii]
AID - 10.1002/brb3.2200 [doi]
PST - ppublish
SO  - Brain Behav. 2021 Jul;11(7):e02200. doi: 10.1002/brb3.2200. Epub 2021 Jun 9.