PMID- 34106962 OWN - NLM STAT- MEDLINE DCOM- 20211026 LR - 20211026 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 16 IP - 6 DP - 2021 TI - Correlation between thoracolumbar disc degeneration and anatomical spinopelvic parameters in supine position on MRI. PG - e0252385 LID - 10.1371/journal.pone.0252385 [doi] LID - e0252385 AB - OBJECTIVE: This study aims to investigate the correlation between spinopelvic parameters in supine position (pelvic incidence (PI), sacral slope (SS), pelvic tilt (PT), lumbar lordosis (LL)), disc degeneration and herniation of the thoracolumbar spine, as well as cardiovascular risk factors and back pain in a southern German cohort from the general population. METHODS: This study is a cross-sectional, case-control study drawn from a prospective cohort of the "Cooperative Health Research in the Region of Augsburg/Kooperative Gesundheitsforschung in der Region Augsburg" study (KORA). In total, 374 participants (mean age 56.4 +/- 9.2 years; 57.8% male) from the whole-body MRI cohort (FF4) were included. All participants underwent a standardized whole-body MRI on which disc degeneration of the thoracic and lumbar spine was evaluated using a sequence adapted Pfirrmann score. PI, PT, SS and LL were measured according to the description in the literature, using sagittal imaging. Furthermore, disc bulging and protrusion were assessed. Correlations were estimated by logistic regression models providing odds ratios. RESULTS: Mean PI was 54.0 degrees +/- 11.1 degrees , PT 13.0 degrees +/- 5.8 degrees , SS 40.2 degrees +/- 8.8 degrees and LL 36.2 degrees +/- 9.6 degrees . SS was greater in men (p<0.05) and lumbar lordosis in women (p<0.001). PT increased by 0.09 degrees per age-year with rising age. Age was not associated with PI, SS and LL. Neither BMI, hypertension, cholesterol, lipid levels, nor physical activity were associated with PI, PT, SS or LL. Diabetes mellitus negatively correlated with SS (beta = -4.19; 95%CI -7.31-1.06, p<0.01). Smaller spinopelvic parameters (PI, SS and LL) where significantly (p<0.05) correlated with an increased frequency of disc bulging, as well as a local clustering in the lumbar, but not the thoracic spine. CONCLUSION: In conclusion, spinopelvic parameters, measured in supine position, are significantly correlated with disc bulging alone; there is no significant correlation between supine spinopelvic parameters and disc degeneration, back pain or cardiovascular risk factors. FAU - Walter, Sven S AU - Walter SS AUID- ORCID: 0000-0002-2870-825X AD - Department for Diagnostic and Interventional Radiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tubingen, Germany. FAU - Lorbeer, Roberto AU - Lorbeer R AD - Department of Radiology, Ludwig-Maximilian-University Hospital Marchioninistrasse, Munich, Germany. FAU - Hefferman, Gerald AU - Hefferman G AUID- ORCID: 0000-0002-5135-3282 AD - Brigham and Women's Hospital, Department of Radiology and Harvard Medical School, Boston, MA, United States of America. FAU - Schlett, Christopher L AU - Schlett CL AD - Department of Diagnostic and Interventional Radiology, Medical Center - University of Freiburg, Freiburg, Germany. FAU - Peters, Anette AU - Peters A AD - Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center forEnvironmental Health, Neuherberg, Germany. AD - Medical Faculty, Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - German Center for Diabetes Research (DZD), Partner site Neuherberg, Neuherberg, Germany. FAU - Rospleszcz, Susanne AU - Rospleszcz S AD - Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center forEnvironmental Health, Neuherberg, Germany. AD - Medical Faculty, Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Nikolaou, Konstantin AU - Nikolaou K AD - Department for Diagnostic and Interventional Radiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tubingen, Germany. FAU - Bamberg, Fabian AU - Bamberg F AD - Department of Diagnostic and Interventional Radiology, Medical Center - University of Freiburg, Freiburg, Germany. FAU - Notohamiprodjo, Mike AU - Notohamiprodjo M AUID- ORCID: 0000-0002-2751-1439 AD - Department for Diagnostic and Interventional Radiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tubingen, Germany. AD - Die Radiologie, Munich, Germany. FAU - Maurer, Elke AU - Maurer E AD - Department for Trauma and Reconstructive Surgery, BG Unfallklinik Tuebingen, Eberhard Karls University Tuebingen, Tuebingen, Germany. LA - eng PT - Journal Article DEP - 20210609 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Female MH - Heart Disease Risk Factors MH - Humans MH - Intervertebral Disc Degeneration/*diagnostic imaging MH - Lumbar Vertebrae/*diagnostic imaging MH - Magnetic Resonance Imaging/*methods MH - Male MH - Middle Aged MH - Pelvic Bones/*diagnostic imaging MH - Supine Position MH - Thoracic Vertebrae/*diagnostic imaging PMC - PMC8189447 COIS- The authors have declared that no competing interests exist. EDAT- 2021/06/10 06:00 MHDA- 2021/10/27 06:00 PMCR- 2021/06/09 CRDT- 2021/06/09 17:25 PHST- 2021/02/27 00:00 [received] PHST- 2021/05/15 00:00 [accepted] PHST- 2021/06/09 17:25 [entrez] PHST- 2021/06/10 06:00 [pubmed] PHST- 2021/10/27 06:00 [medline] PHST- 2021/06/09 00:00 [pmc-release] AID - PONE-D-21-06584 [pii] AID - 10.1371/journal.pone.0252385 [doi] PST - epublish SO - PLoS One. 2021 Jun 9;16(6):e0252385. doi: 10.1371/journal.pone.0252385. eCollection 2021.