PMID- 34110720
OWN - NLM
STAT- MEDLINE
DCOM- 20220202
LR  - 20240402
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 9
IP  - 11
DP  - 2021 Jun
TI  - Serum MMP-3 and its association with central arterial stiffness among young 
      adults is moderated by smoking and BMI.
PG  - e14920
LID - 10.14814/phy2.14920 [doi]
LID - e14920
AB  - Central arterial stiffness is an independent predictor of cardiovascular disease. 
      It is characterized by a marked reduction in the elastin-collagen ratio of the 
      arterial wall extracellular matrix (ECM), and is largely the result of 
      degradation of various ECM components. Matrix metalloproteinase-3 (MMP-3) may 
      contribute to central arterial stiffness via its involvement in ECM homeostasis 
      and remodeling. This study examined the association between serum MMP-3 
      concentrations and central arterial stiffness and potential interactions of MMP-3 
      and traditional cardiovascular risk factors in a population of healthy young 
      adults. A total of 206 participants (n = 109 females) aged 19-25 years were 
      included in the current study. Central arterial stiffness was measured 
      non-invasively as carotid-femoral pulse wave velocity (cfPWV) (m/s). MMP-3 
      concentrations (ng/ml) were measured using ELISA techniques. Regression analyses 
      were used to examine the association between cfPWV and MMP-3, adjusting for age, 
      sex, smoking status, body mass index (BMI), instantaneous mean arterial pressure 
      (MAP) and heart rate, and serum C-reactive protein. Interactions between MMP-3 
      with smoking, BMI, sex, and MAP were analyzed in subsequent regression models. 
      MMP-3 was an independent predictor of cfPWV (beta = 0.187, p = 0.007), and 
      significant interactions between MMP-3 and regular smoking (beta = 0.291, 
      p = 0.022), and MMP-3 and BMI (beta = 0.210, p = 0.013) were observed. Higher serum 
      MMP-3 concentrations were associated with a faster cfPWV and thus, greater 
      central arterial stiffness. Interactions between MMP-3 and smoking, and MMP-3 and 
      BMI may, in part, drive the association between MMP-3 and central arterial 
      stiffness.
CI  - (c) 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on 
      behalf of The Physiological Society and the American Physiological Society.
FAU - Iannarelli, Nathaniel J
AU  - Iannarelli NJ
AD  - Department of Health Sciences, Faculty of Applied Health Sciences, Brock 
      University, Saint Catharines, ON, Canada.
FAU - MacNeil, Adam J
AU  - MacNeil AJ
AD  - Department of Health Sciences, Faculty of Applied Health Sciences, Brock 
      University, Saint Catharines, ON, Canada.
FAU - Dempster, Kylie S
AU  - Dempster KS
AD  - Department of Health Sciences, Faculty of Applied Health Sciences, Brock 
      University, Saint Catharines, ON, Canada.
AD  - Brock-Niagara Centre for Health and Well-Being, Brock University, Saint 
      Catharines, ON, Canada.
FAU - Wade, Terrance J
AU  - Wade TJ
AD  - Department of Health Sciences, Faculty of Applied Health Sciences, Brock 
      University, Saint Catharines, ON, Canada.
AD  - Brock-Niagara Centre for Health and Well-Being, Brock University, Saint 
      Catharines, ON, Canada.
FAU - O'Leary, Deborah D
AU  - O'Leary DD
AUID- ORCID: 0000-0002-0635-1536
AD  - Department of Health Sciences, Faculty of Applied Health Sciences, Brock 
      University, Saint Catharines, ON, Canada.
AD  - Brock-Niagara Centre for Health and Well-Being, Brock University, Saint 
      Catharines, ON, Canada.
LA  - eng
GR  - 363774/CIHR/Canada
GR  - 399332/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Blood Pressure
MH  - *Body Mass Index
MH  - C-Reactive Protein/analysis
MH  - Female
MH  - Heart Disease Risk Factors
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Smoking/*adverse effects
MH  - *Vascular Stiffness/physiology
MH  - Young Adult
PMC - PMC8191404
OTO - NOTNLM
OT  - arterial stiffness
OT  - body mass index
OT  - central arterial stiffness
OT  - matrix metalloproteinases
OT  - smoking
COIS- The authors declare no competing interests associated with this manuscript.
EDAT- 2021/06/11 06:00
MHDA- 2022/02/03 06:00
PMCR- 2021/06/10
CRDT- 2021/06/10 12:42
PHST- 2021/04/26 00:00 [revised]
PHST- 2021/02/02 00:00 [received]
PHST- 2021/05/14 00:00 [accepted]
PHST- 2021/06/10 12:42 [entrez]
PHST- 2021/06/11 06:00 [pubmed]
PHST- 2022/02/03 06:00 [medline]
PHST- 2021/06/10 00:00 [pmc-release]
AID - PHY214920 [pii]
AID - 10.14814/phy2.14920 [doi]
PST - ppublish
SO  - Physiol Rep. 2021 Jun;9(11):e14920. doi: 10.14814/phy2.14920.