PMID- 34111182
OWN - NLM
STAT- MEDLINE
DCOM- 20211111
LR  - 20211111
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 16
IP  - 6
DP  - 2021
TI  - Perinatal exposure to a human relevant mixture of persistent organic pollutants: 
      Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 
      mice.
PG  - e0252954
LID - 10.1371/journal.pone.0252954 [doi]
LID - e0252954
AB  - The ability of persistent organic pollutants (POPs) with endocrine disrupting 
      properties to interfere with the developing reproductive system is of increasing 
      concern. POPs are transferred from dams to offspring and the high sensitivity of 
      neonates to endocrine disturbances may be caused by underdeveloped systems of 
      metabolism and excretion. The present study aimed to characterize the effect of 
      in utero and lactational exposure to a human relevant mixture of POPs on the 
      female mammary gland, ovarian folliculogenesis and liver function in CD-1 
      offspring mice. Dams were exposed to the mixture through the diet at Control, Low 
      or High doses (representing 0x, 5000x and 100 000x human estimated daily intake 
      levels, respectively) from weaning and throughout mating, gestation, and 
      lactation. Perinatally exposed female offspring exhibited altered mammary gland 
      development and a suppressed ovarian follicle maturation. Increased hepatic 
      cytochrome P450 enzymatic activities indirectly indicated activation of nuclear 
      receptors and potential generation of reactive products. Hepatocellular 
      hypertrophy was observed from weaning until 30 weeks of age and could potentially 
      lead to hepatotoxicity. Further studies should investigate the effects of human 
      relevant mixtures of POPs on several hormones combined with female reproductive 
      ability and liver function.
FAU - Johanson, Silje Modahl
AU  - Johanson SM
AUID- ORCID: 0000-0001-8377-7824
AD  - Department of Production Animal Clinical Sciences, Norwegian University of Life 
      Sciences, As, Norway.
FAU - Ropstad, Erik
AU  - Ropstad E
AD  - Department of Production Animal Clinical Sciences, Norwegian University of Life 
      Sciences, As, Norway.
FAU - Ostby, Gunn Charlotte
AU  - Ostby GC
AD  - Department of Production Animal Clinical Sciences, Norwegian University of Life 
      Sciences, As, Norway.
FAU - Aleksandersen, Mona
AU  - Aleksandersen M
AD  - Department of Preclinical Sciences and Pathology, Norwegian University of Life 
      Sciences, As, Norway.
FAU - Zamaratskaia, Galia
AU  - Zamaratskaia G
AD  - Department of Molecular Sciences, Swedish University of Agricultural Sciences, 
      Uppsala, Sweden.
FAU - Boge, Gudrun Seeberg
AU  - Boge GS
AD  - Department of Companion Animal Clinical Sciences, Norwegian University of Life 
      Sciences, As, Norway.
FAU - Halsne, Ruth
AU  - Halsne R
AD  - Division of Laboratory Medicine, Department of Forensic Sciences, Oslo University 
      Hospital, Oslo, Norway.
FAU - Trangerud, Cathrine
AU  - Trangerud C
AD  - Department of Companion Animal Clinical Sciences, Norwegian University of Life 
      Sciences, As, Norway.
FAU - Lyche, Jan Ludvig
AU  - Lyche JL
AD  - Department of Paraclinical Sciences, Norwegian University of Life Sciences, As, 
      Norway.
FAU - Berntsen, Hanne Friis
AU  - Berntsen HF
AD  - Department of Production Animal Clinical Sciences, Norwegian University of Life 
      Sciences, As, Norway.
AD  - National Institute of Occupational Health, Oslo, Norway.
FAU - Zimmer, Karin Elisabeth
AU  - Zimmer KE
AD  - Department of Preclinical Sciences and Pathology, Norwegian University of Life 
      Sciences, As, Norway.
FAU - Verhaegen, Steven
AU  - Verhaegen S
AD  - Department of Production Animal Clinical Sciences, Norwegian University of Life 
      Sciences, As, Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210610
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Endocrine Disruptors)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
SB  - IM
MH  - Animals
MH  - Cytochrome P-450 Enzyme System/metabolism
MH  - Endocrine Disruptors/*toxicity
MH  - Female
MH  - Humans
MH  - Lactation/drug effects
MH  - Liver/drug effects/*physiology
MH  - Liver Function Tests
MH  - Mammary Glands, Animal/drug effects/*growth & development
MH  - Maternal Exposure/*adverse effects
MH  - Mice
MH  - Ovarian Follicle/drug effects/*growth & development
MH  - Persistent Organic Pollutants/*toxicity
MH  - Pregnancy
MH  - Up-Regulation
PMC - PMC8191980
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/06/11 06:00
MHDA- 2021/11/12 06:00
PMCR- 2021/06/10
CRDT- 2021/06/10 17:24
PHST- 2020/12/02 00:00 [received]
PHST- 2021/05/25 00:00 [accepted]
PHST- 2021/06/10 17:24 [entrez]
PHST- 2021/06/11 06:00 [pubmed]
PHST- 2021/11/12 06:00 [medline]
PHST- 2021/06/10 00:00 [pmc-release]
AID - PONE-D-20-37867 [pii]
AID - 10.1371/journal.pone.0252954 [doi]
PST - epublish
SO  - PLoS One. 2021 Jun 10;16(6):e0252954. doi: 10.1371/journal.pone.0252954. 
      eCollection 2021.