PMID- 34111252
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20230202
IS  - 2164-2591 (Electronic)
IS  - 2164-2591 (Linking)
VI  - 10
IP  - 6
DP  - 2021 May 3
TI  - Longitudinal Study of Retinal Structure, Vascular, and Neuronal Function in 
      Patients With Relapsing-Remitting Multiple Sclerosis: 1-Year Follow-Up.
PG  - 6
LID - 10.1167/tvst.10.6.6 [doi]
LID - 6
AB  - OBJECTIVE: The purpose of this study was to quantify retinal structural, 
      vascular, and functional changes in patients with relapsing-remitting multiple 
      sclerosis (RRMS) over 1 year. METHODS: Eighty-eight eyes of 44 patients with RRMS 
      underwent assessments of low contrast letter acuity (LCLA), retinal ganglion cell 
      function detected by the steady-state pattern electroretinogram (PERG), axonal 
      microstructural integrity measured as birefringence, intraretinal layer 
      thicknesses by ultra-high-resolution optical coherence tomography (OCT), 
      volumetric vessel density (VVD) by OCT angiography, and retinal tissue perfusion 
      (RTP) by the Retinal Function Imager (RFI). All measurements were performed at 
      baseline and 1-year follow-up. The impacts of disease activities and a history of 
      optic neuritis (ON) were analyzed. RESULTS: Compared to baseline, there were no 
      significant differences in all variables (P > 0.05), except for the axonal 
      birefringence and RTP. The birefringence's of the retinal fiber layer at the 
      temporal and superior quadrants was significantly decreased (P < 0.05), whereas 
      RTP was significantly increased (P < 0.05). In the subgroup with ON, 
      significantly longer PERG latency and decreased VVD were observed at follow-up (P 
      < 0.05). In patients with improved LCLA, significantly increased RTP and 
      decreased VVD (P < 0.05) were also observed. CONCLUSIONS: This is the first 
      longitudinal study that assessed the RTP and VVD, along with other retinal 
      structural and functional parameters in MS. The recovery of retinal vascular 
      function occurred with the improved LCLA, suggesting that these measurements may 
      be associated with disease progression. TRANSLATIONAL RELEVANCE: The retinal 
      microvascular changes could be potential biomarkers for monitoring therapeutic 
      efficacy in MS.
FAU - Chen, Qi
AU  - Chen Q
AD  - School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, 
      China.
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, FL, USA.
FAU - Jiang, Hong
AU  - Jiang H
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, FL, USA.
AD  - Department of Neurology, University of Miami Miller School of Medicine, Miami, 
      FL, USA.
FAU - Delgado, Silvia
AU  - Delgado S
AD  - Department of Neurology, University of Miami Miller School of Medicine, Miami, 
      FL, USA.
FAU - Hernandez, Jeffrey
AU  - Hernandez J
AD  - Department of Neurology, University of Miami Miller School of Medicine, Miami, 
      FL, USA.
FAU - Alba, Diego Eduardo
AU  - Alba DE
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, FL, USA.
FAU - Gregori, Giovanni
AU  - Gregori G
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, FL, USA.
FAU - Rammohan, Kottil W
AU  - Rammohan KW
AD  - Department of Neurology, University of Miami Miller School of Medicine, Miami, 
      FL, USA.
FAU - Porciatti, Vittorio
AU  - Porciatti V
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, FL, USA.
FAU - Wang, Jianhua
AU  - Wang J
AD  - Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami 
      Miller School of Medicine, Miami, FL, USA.
LA  - eng
GR  - P30 EY014801/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transl Vis Sci Technol
JT  - Translational vision science & technology
JID - 101595919
SB  - IM
MH  - Follow-Up Studies
MH  - Humans
MH  - Longitudinal Studies
MH  - *Multiple Sclerosis
MH  - *Multiple Sclerosis, Relapsing-Remitting/diagnostic imaging
MH  - Retina/diagnostic imaging
PMC - PMC8107487
COIS- Disclosure: Q. Chen, None; H. Jiang, None; S. Delgado, None; J. Hernandez, None; 
      D.E. Alba, None; G. Gregori, None; K.W. Rammohan, None; V. Porciatti, None; J. 
      Wang, None
EDAT- 2021/06/11 06:00
MHDA- 2021/06/29 06:00
PMCR- 2021/05/05
CRDT- 2021/06/10 17:27
PHST- 2021/06/10 17:27 [entrez]
PHST- 2021/06/11 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2021/05/05 00:00 [pmc-release]
AID - 2772568 [pii]
AID - TVST-20-2898 [pii]
AID - 10.1167/tvst.10.6.6 [doi]
PST - ppublish
SO  - Transl Vis Sci Technol. 2021 May 3;10(6):6. doi: 10.1167/tvst.10.6.6.