PMID- 34111294
OWN - NLM
STAT- MEDLINE
DCOM- 20220302
LR  - 20240327
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 48
IP  - 1
DP  - 2022 Jan 21
TI  - An Event-Related Potential Investigation of Early Visual Processing Deficits 
      During Face Perception in Youth at Clinical High Risk for Psychosis.
PG  - 90-99
LID - 10.1093/schbul/sbab068 [doi]
AB  - Impairments in early visual face perception are well documented in patients with 
      schizophrenia. Specifically, event-related potential (ERP) research in patients 
      with schizophrenia has demonstrated deficits in early sensory processing of 
      stimulus properties (P1 component) and the structural encoding of faces (N170 
      component). However, it is not well understood if similar impairments are present 
      in individuals at clinical high risk (CHR) for psychosis (ie, those in the 
      putative prodromal stage of the illness). Thus, it is unknown if face perception 
      deficits are the result of illness onset or are present in the high-risk period 
      for the illness. The present study used the ERP technique to examine neural 
      activation when viewing facial emotion expressions and objects in 44 CHR and 47 
      control adolescents and young adults (N = 91). P1 amplitude was similar across 
      groups, indicating that early sensory processing impairments did not 
      substantially contribute to face perception deficits in CHR youth. CHR youth 
      exhibited reduced N170 amplitude compared to controls when viewing faces but not 
      objects, implicating a specific deficit in the structural encoding of faces 
      rather than a general perceptual deficit. Further, whereas controls demonstrated 
      the expected face-selective N170 effect (ie, larger amplitude for faces than 
      objects), CHR youth did not, which suggests that facial emotion expressions do 
      not elicit the expected preferential perceptual processing for critical social 
      information in individuals at CHR for psychosis. Together, these findings provide 
      valuable information regarding the specific impairments contributing to face 
      perception deficits in the high-risk period where treatment stands to aid in 
      preventing illness progression.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      Maryland Psychiatric Research Center.All rights reserved. For permissions, please 
      email: journals.permissions@oup.com.
FAU - Osborne, K Juston
AU  - Osborne KJ
AD  - Department of Psychology, Northwestern University, Evanston, IL, USA.
FAU - Kraus, Brian
AU  - Kraus B
AD  - Department of Psychology, Northwestern University, Evanston, IL, USA.
FAU - Curran, Tim
AU  - Curran T
AD  - Department of Psychology and Neuroscience, University of Colorado, Boulder, 
      Boulder, CO, USA.
FAU - Earls, Holly
AU  - Earls H
AD  - Department of Psychology and Neuroscience, University of Colorado, Boulder, 
      Boulder, CO, USA.
FAU - Mittal, Vijay A
AU  - Mittal VA
AUID- ORCID: 0000-0001-9017-5119
AD  - Department of Psychology, Northwestern University, Evanston, IL, USA.
AD  - Department of Psychiatry, Northwestern University, Evanston, IL, USA.
AD  - Institute for Policy Research, Northwestern University, Evanston, IL, USA.
AD  - Department of Medical Social Sciences, Evanston, IL, USA.
AD  - Institute for Innovations in Developmental Sciences (DevSci), Evanston, Chicago, 
      IL, USA.
LA  - eng
GR  - R33 MH103231/MH/NIMH NIH HHS/United States
GR  - R21 MH103231/MH/NIMH NIH HHS/United States
GR  - T32 NS047987/NS/NINDS NIH HHS/United States
GR  - R01 MH094650/MH/NIMH NIH HHS/United States
GR  - F31 MH123121/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cognitive Dysfunction/etiology/*physiopathology
MH  - Disease Susceptibility
MH  - Evoked Potentials/*physiology
MH  - Facial Expression
MH  - Facial Recognition/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Prodromal Symptoms
MH  - Psychotic Disorders/complications/*physiopathology
MH  - Risk
MH  - *Social Perception
MH  - Young Adult
PMC - PMC8781328
OTO - NOTNLM
OT  - N170
OT  - P1
OT  - clinical high risk
OT  - event-related potential
OT  - face perception
OT  - psychosis
EDAT- 2021/06/11 06:00
MHDA- 2022/03/03 06:00
PMCR- 2022/06/10
CRDT- 2021/06/10 17:28
PHST- 2021/06/11 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2021/06/10 17:28 [entrez]
PHST- 2022/06/10 00:00 [pmc-release]
AID - 6296027 [pii]
AID - sbab068 [pii]
AID - 10.1093/schbul/sbab068 [doi]
PST - ppublish
SO  - Schizophr Bull. 2022 Jan 21;48(1):90-99. doi: 10.1093/schbul/sbab068.