PMID- 34115015
OWN - NLM
STAT- MEDLINE
DCOM- 20210622
LR  - 20230103
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 100
IP  - 23
DP  - 2021 Jun 11
TI  - Effects of pain on depression, sleep, exercise tolerance, and quality of life in 
      patients with nontuberculous mycobacterial pulmonary disease.
PG  - e26249
LID - 10.1097/MD.0000000000026249 [doi]
LID - e26249
AB  - The experience and causes of pain in patients with nontuberculous mycobacterial 
      pulmonary disease (NTM-PD) have not been clarified.This study aimed to determine 
      the prevalence and severity of bodily pain (BP) in patients with NTM-PD. We also 
      investigated the clinical indicators that contribute to pain.We used a 
      retrospective cross-sectional study design. The participants were 114 NTM-PD 
      patients (109 women) with a mean age of 65 years. The prevalence and severity of 
      pain were measured using 2 items from the 36-Item Short Form Survey version 2 
      (SF-36), and the BP score was calculated. Functional limitation due to dyspnea 
      was quantified using the Modified Medical Research Council Dyspnea Scale (mMRC), 
      depression was assessed using the Center for Epidemiological Studies Depression 
      Scale (CES-D), sleep quality was assessed using the Pittsburgh Sleep Quality 
      Index (PSQI); health-related quality of life was assessed using the Leicester 
      Cough Questionnaire (LCQ), and exercise tolerance was measured using the 
      Incremental Shuttle Walk Test (ISWT).Pain was reported by 70.2% of the patients 
      (n = 80), and of these, 35.7% (n = 25) reported moderate to very severe pain. 
      NTM-PD patients with high levels of pain had significantly higher scores on the 
      mMRC, CES-D, and PSQI scores, and significantly lower performance on the ISWT and 
      LCQ. Multiple regression analysis identified ISWT, CES-D, and PSQI as independent 
      factors that affected BP scores.Our findings suggest that pain significantly 
      impacts daily life associated with reduced exercise tolerance, the presence of 
      depressive symptoms, and poor sleep quality in patients with NTM-PD.
CI  - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Mori, Kosuke
AU  - Mori K
AD  - Department of Clinical Mycobacteriology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki.
AD  - Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan 
      Anti-Tuberculosis Association.
FAU - Tabusadani, Mitsuru
AU  - Tabusadani M
AD  - Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan 
      Anti-Tuberculosis Association.
FAU - Yamane, Kazumasa
AU  - Yamane K
AD  - Department of Clinical Mycobacteriology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki.
AD  - Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan 
      Anti-Tuberculosis Association.
FAU - Takao, Satoshi
AU  - Takao S
AD  - Department of Clinical Mycobacteriology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki.
AD  - Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan 
      Anti-Tuberculosis Association.
FAU - Kuroyama, Yuki
AU  - Kuroyama Y
AD  - Department of Clinical Mycobacteriology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki.
AD  - Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan 
      Anti-Tuberculosis Association.
FAU - Matsumura, Yusuke
AU  - Matsumura Y
AD  - Department of Clinical Mycobacteriology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki.
AD  - Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan 
      Anti-Tuberculosis Association.
FAU - Ono, Kazuki
AU  - Ono K
AD  - Department of Clinical Mycobacteriology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki.
AD  - Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan 
      Anti-Tuberculosis Association.
FAU - Kawahara, Kazuma
AU  - Kawahara K
AD  - Department of Clinical Mycobacteriology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki.
AD  - Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan 
      Anti-Tuberculosis Association.
FAU - Omatsu, Shunya
AU  - Omatsu S
AD  - Department of Clinical Mycobacteriology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki.
AD  - Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan 
      Anti-Tuberculosis Association.
FAU - Fujiwara, Keiji
AU  - Fujiwara K
AD  - Respiratory Diseases Center, Fukujuji Hospital, Japan Anti-Tuberculosis 
      Association, Tokyo.
FAU - Furuuchi, Koji
AU  - Furuuchi K
AD  - Respiratory Diseases Center, Fukujuji Hospital, Japan Anti-Tuberculosis 
      Association, Tokyo.
AD  - Department of Basic Mycobacteriology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki.
FAU - Morimoto, Kozo
AU  - Morimoto K
AD  - Respiratory Diseases Center, Fukujuji Hospital, Japan Anti-Tuberculosis 
      Association, Tokyo.
AD  - Division of Clinical Research, Fukujuji Hospital, Japan Anti-Tuberculosis 
      Association, Tokyo, Japan.
FAU - Kimura, Hiroshi
AU  - Kimura H
AD  - Department of Clinical Mycobacteriology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki.
AD  - Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan 
      Anti-Tuberculosis Association.
AD  - Respiratory Diseases Center, Fukujuji Hospital, Japan Anti-Tuberculosis 
      Association, Tokyo.
FAU - Senjyu, Hideaki
AU  - Senjyu H
AUID- ORCID: 0000-0003-0489-8615
AD  - Department of Clinical Mycobacteriology, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki.
AD  - Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan 
      Anti-Tuberculosis Association.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Depression/epidemiology/etiology/*psychology
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Mycobacterium/pathogenicity
MH  - Pain/*complications/epidemiology/psychology
MH  - Pain Measurement/methods
MH  - Prevalence
MH  - Psychometrics/instrumentation/methods
MH  - Quality of Life/psychology
MH  - Respiratory Tract Diseases/*complications/epidemiology/physiopathology
MH  - Retrospective Studies
MH  - Sleep/*physiology
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
PMC - PMC8202577
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2021/06/12 06:00
MHDA- 2021/06/23 06:00
PMCR- 2021/06/11
CRDT- 2021/06/11 12:17
PHST- 2021/02/07 00:00 [received]
PHST- 2021/05/19 00:00 [accepted]
PHST- 2021/06/11 12:17 [entrez]
PHST- 2021/06/12 06:00 [pubmed]
PHST- 2021/06/23 06:00 [medline]
PHST- 2021/06/11 00:00 [pmc-release]
AID - 00005792-202106110-00038 [pii]
AID - MD-D-21-00907 [pii]
AID - 10.1097/MD.0000000000026249 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2021 Jun 11;100(23):e26249. doi: 
      10.1097/MD.0000000000026249.