PMID- 34117382
OWN - NLM
STAT- MEDLINE
DCOM- 20210920
LR  - 20240403
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 35
IP  - 9
DP  - 2021 Sep
TI  - Clinical electrophysiology of the optic nerve and retinal ganglion cells.
PG  - 2386-2405
LID - 10.1038/s41433-021-01614-x [doi]
AB  - Clinical electrophysiological assessment of optic nerve and retinal ganglion cell 
      function can be performed using the Pattern Electroretinogram (PERG), Visual 
      Evoked Potential (VEP) and the Photopic Negative Response (PhNR) amongst other 
      more specialised techniques. In this review, we describe these 
      electrophysiological techniques and their application in diseases affecting the 
      optic nerve and retinal ganglion cells with the exception of glaucoma. The 
      disease groups discussed include hereditary, compressive, toxic/nutritional, 
      traumatic, vascular, inflammatory and intracranial causes for optic nerve or 
      retinal ganglion cell dysfunction. The benefits of objective, 
      electrophysiological measurement of the retinal ganglion cells and optic nerve 
      are discussed, as are their applications in clinical diagnosis of disease, 
      determining prognosis, monitoring progression and response to novel therapies.
CI  - (c) 2021. The Author(s).
FAU - Marmoy, Oliver R
AU  - Marmoy OR
AUID- ORCID: 0000-0003-2022-3669
AD  - Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital 
      for Children, London, UK. o.marmoy@nhs.net.
AD  - UCL-GOS Institute for Child Health, University College London, London, UK. 
      o.marmoy@nhs.net.
AD  - Manchester Metropolitan University, Manchester, UK. o.marmoy@nhs.net.
FAU - Viswanathan, Suresh
AU  - Viswanathan S
AD  - College of Optometry, State University of New York, New York, NY, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210611
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
SB  - IM
EIN - Eye (Lond). 2023 Apr;37(6):1290. PMID: 34645971
MH  - Electroretinography
MH  - Evoked Potentials, Visual
MH  - *Glaucoma/diagnosis
MH  - Humans
MH  - Optic Nerve
MH  - *Retinal Ganglion Cells
PMC - PMC8377055
COIS- The authors declare no competing interests.
EDAT- 2021/06/13 06:00
MHDA- 2021/09/21 06:00
PMCR- 2021/06/11
CRDT- 2021/06/12 06:12
PHST- 2021/03/17 00:00 [received]
PHST- 2021/05/19 00:00 [accepted]
PHST- 2021/05/11 00:00 [revised]
PHST- 2021/06/13 06:00 [pubmed]
PHST- 2021/09/21 06:00 [medline]
PHST- 2021/06/12 06:12 [entrez]
PHST- 2021/06/11 00:00 [pmc-release]
AID - 10.1038/s41433-021-01614-x [pii]
AID - 1614 [pii]
AID - 10.1038/s41433-021-01614-x [doi]
PST - ppublish
SO  - Eye (Lond). 2021 Sep;35(9):2386-2405. doi: 10.1038/s41433-021-01614-x. Epub 2021 
      Jun 11.