PMID- 34117950
OWN - NLM
STAT- MEDLINE
DCOM- 20211019
LR  - 20220531
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 40
IP  - 11
DP  - 2021 Nov
TI  - Serum cartilage oligomeric matrix protein is correlated with quantitative 
      magnetic resonance imaging and arthroscopic cartilage findings in anterior 
      cruciate ligament deficient knees without osteoarthritic changes.
PG  - 4629-4638
LID - 10.1007/s10067-021-05800-w [doi]
AB  - INTRODUCTION/OBJECTIVES: To investigate the association between serum biomarker 
      [cartilage oligomeric matrix protein (COMP) and matrix metalloproteinase-3 
      (MMP-3)] levels and clinical, magnetic resonance imaging (MRI), and arthroscopic 
      findings in anterior cruciate ligament (ACL)-deficient knees without 
      osteoarthritic changes on radiographs. METHOD: Patients with ACL injury of 
      Kellgren-Lawrence grade 0 or 1 were enrolled. Serum COMP and MMP-3 levels were 
      measured preoperatively. Correlations of serum biomarker levels with age, body 
      mass index (BMI), duration from time of injury, Tegner activity scale (TAS) 
      score, Lysholm knee score, International Knee Documentation Committee score, 
      KT-1000 arthrometer measurements, whole-organ MRI score (WORMS), MRI T2 
      relaxation time, and arthroscopic International Cartilage Research Society (ICRS) 
      grade were assessed by calculating Spearman correlation coefficients. 
      Associations between intraoperative findings (cartilage, meniscus) and serum 
      biomarker levels were determined using the Mann-Whitney U test. Multiple 
      regression analysis was performed to investigate the correlations between serum 
      biomarker levels and MRI and arthroscopic findings. RESULTS: Ninety-eight 
      patients with a mean age of 23.7 years were enrolled. Higher serum COMP level was 
      correlated with older age and higher BMI, TAS score, serum MMP-3 level, WORMS, 
      and T2 relaxation times (medial femur, medial tibia). Multivariate analysis 
      showed that the serum COMP level was independently associated with WORMS and ICRS 
      grade. CONCLUSIONS: The serum COMP level was correlated with age, BMI, TAS score, 
      and MMP-3 level in ACL-deficient knees and was independently correlated with 
      WORMS and ICRS grade. Thus, the serum COMP level can help detect cartilage 
      degeneration even in patients without radiographic osteoarthritic changes. Key 
      Points * Serum COMP correlated with WORMS and ICRS grade in ACL deficient knee. * 
      The serum COMP level could help in detecting cartilage degeneration, even in 
      patients with no radiographic osteoarthritic changes.
CI  - (c) 2021. International League of Associations for Rheumatology (ILAR).
FAU - Nishida, Yohei
AU  - Nishida Y
AD  - Department of Orthopaedic Surgery, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Hashimoto, Yusuke
AU  - Hashimoto Y
AUID- ORCID: 0000-0001-8138-5341
AD  - Department of Orthopaedic Surgery, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan. 
      hussy@med.osaka-cu.ac.jp.
FAU - Orita, Kumi
AU  - Orita K
AD  - Department of Orthopaedic Surgery, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Nishino, Kazuya
AU  - Nishino K
AD  - Department of Orthopaedic Surgery, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Kinoshita, Takuya
AU  - Kinoshita T
AD  - Department of Orthopaedic Surgery, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
FAU - Nakamura, Hiroaki
AU  - Nakamura H
AD  - Department of Orthopaedic Surgery, Osaka City University Graduate School of 
      Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210612
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 0 (Cartilage Oligomeric Matrix Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anterior Cruciate Ligament/diagnostic imaging/surgery
MH  - *Anterior Cruciate Ligament Reconstruction
MH  - Cartilage Oligomeric Matrix Protein
MH  - *Cartilage, Articular/diagnostic imaging
MH  - Humans
MH  - Knee Joint/diagnostic imaging/surgery
MH  - Magnetic Resonance Imaging
MH  - *Osteoarthritis, Knee/diagnostic imaging/surgery
MH  - Young Adult
OTO - NOTNLM
OT  - Anterior cruciate ligament deficient knee
OT  - Biomarker
OT  - Cartilage oligomeric matrix protein
OT  - Early knee osteoarthritis
OT  - Magnetic resonance imaging
EDAT- 2021/06/13 06:00
MHDA- 2021/10/21 06:00
CRDT- 2021/06/12 12:09
PHST- 2020/12/28 00:00 [received]
PHST- 2021/05/30 00:00 [accepted]
PHST- 2021/05/24 00:00 [revised]
PHST- 2021/06/13 06:00 [pubmed]
PHST- 2021/10/21 06:00 [medline]
PHST- 2021/06/12 12:09 [entrez]
AID - 10.1007/s10067-021-05800-w [pii]
AID - 10.1007/s10067-021-05800-w [doi]
PST - ppublish
SO  - Clin Rheumatol. 2021 Nov;40(11):4629-4638. doi: 10.1007/s10067-021-05800-w. Epub 
      2021 Jun 12.