PMID- 34117967
OWN - NLM
STAT- MEDLINE
DCOM- 20220830
LR  - 20240424
IS  - 1573-6830 (Electronic)
IS  - 0272-4340 (Linking)
VI  - 42
IP  - 7
DP  - 2022 Oct
TI  - The CXCL12/CXCR4/ACKR3 Response Axis in Chronic Neurodegenerative Disorders of 
      the Central Nervous System: Therapeutic Target and Biomarker.
PG  - 2147-2156
LID - 10.1007/s10571-021-01115-1 [doi]
AB  - There has been an increase in the incidence of chronic neurodegenerative 
      disorders of the central nervous system, including Alzheimer's and Parkinson's 
      diseases, over the recent years mostly due to the rise in the number of elderly 
      individuals. In addition, various neurodegenerative disorders are related to 
      imbalances in the CXCL12/CXCR4/ACKR3 response axis. Notably, the CXC Chemokine 
      Ligand 12 (CXCL12) is essential for the development of the central nervous 
      system. Moreover, the expression and distribution of CXCL12 and its receptors are 
      associated with the aggravation or alleviation of symptoms of neurodegenerative 
      disorders. Therefore, the current review sought to highlight the specific 
      functions of CXCL12 and its receptors in various neurodegenerative disorders, in 
      order to provide new insights for future research.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Yan, Yudie
AU  - Yan Y
AD  - Department of Ultrasound, First Affiliated Hospital of China Medical University, 
      Liaoning Province, Shenyang City, 110001, People's Republic of China.
FAU - Su, Jingtong
AU  - Su J
AD  - Jinzhou Medical University, Liaoning Province, Jinzhou City, People's Republic of 
      China.
FAU - Zhang, Zhen
AU  - Zhang Z
AUID- ORCID: 0000-0002-4261-0910
AD  - Department of Ultrasound, First Affiliated Hospital of China Medical University, 
      Liaoning Province, Shenyang City, 110001, People's Republic of China. 
      zhangzhen@cmu.edu.cn.
LA  - eng
GR  - 81471809/National Natural Science Foundation of China/
GR  - 81971639/National Natural Science Foundation of China/
GR  - 2019-ZD-0772/Natural Science Foundation of Liaoning Province/
PT  - Journal Article
PT  - Review
DEP - 20210612
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - 0 (Biomarkers)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (CXCR4 protein, human)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Ligands)
RN  - 0 (Receptors, CXCR)
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - Aged
MH  - Biomarkers
MH  - Central Nervous System
MH  - *Chemokine CXCL12
MH  - Humans
MH  - Ligands
MH  - *Receptors, CXCR
MH  - Receptors, CXCR4
MH  - Signal Transduction
OTO - NOTNLM
OT  - ACKR3
OT  - CXCL12
OT  - CXCR4
OT  - Central nervous system
OT  - Neurodegenerative disorders
EDAT- 2021/06/13 06:00
MHDA- 2022/08/31 06:00
CRDT- 2021/06/12 12:10
PHST- 2021/04/05 00:00 [received]
PHST- 2021/06/02 00:00 [accepted]
PHST- 2021/06/13 06:00 [pubmed]
PHST- 2022/08/31 06:00 [medline]
PHST- 2021/06/12 12:10 [entrez]
AID - 10.1007/s10571-021-01115-1 [pii]
AID - 10.1007/s10571-021-01115-1 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2022 Oct;42(7):2147-2156. doi: 10.1007/s10571-021-01115-1. 
      Epub 2021 Jun 12.