PMID- 34118072
OWN - NLM
STAT- MEDLINE
DCOM- 20210811
LR  - 20221207
IS  - 1439-0272 (Electronic)
IS  - 0303-4569 (Linking)
VI  - 53
IP  - 8
DP  - 2021 Sep
TI  - A comprehensive assessment of genetic variation in serotonin transporter gene 
      (5-HTTLPR+rs25531) and the response to dapoxetine in Chinese patients with 
      premature ejaculation.
PG  - e14141
LID - 10.1111/and.14141 [doi]
AB  - This study was to explore whether serotonin transporter gene-linked polymorphic 
      region polymorphisms (5-HTTLPR+rs25531) influence the response to dapoxetine 
      treatment in a Chinese population with premature ejaculation (PE). 112 patients 
      with PE re-enrolled from our previous study received dapoxetine monotherapy. At 
      the endpoint, patients with S'S' had a significant increased risk of nonresponse 
      compared with L' carriers (p < .001). The improvement in S'S' genotype was 
      significantly lower in premature ejaculation profile (PEP) items of 'control over 
      ejaculation' (p = .035) and 'distress related to ejaculation' (p = .017) than 
      that in L' carriers. As to clinical global impression of change (CGIC), results 
      in S'S' subjects showed significantly lower scores (p = .008) and a less 
      satisfaction rate reporting at least 'better' (p = .020) compared with L' 
      carriers. Moreover, our findings suggested that patients with S'S' were more 
      likely to develop adverse effects (AEs) compared with L' carriers (p = .040). 
      This study suggests that PE patients bearing the S'S' genotype have an inferior 
      comprehensive efficacy and safety of dapoxetine treatment, which consist of 
      poorer response in IELTs, less improvement in patient-reported outcome (PRO) 
      measures and greater incidence of AEs, than L' carriers. Variants of triallelic 
      5-HTTLPR may play a major role as a predictor of treatment response to 
      dapoxetine.
CI  - (c) 2021 Wiley-VCH GmbH.
FAU - Huang, Yuanyuan
AU  - Huang Y
AUID- ORCID: 0000-0002-9715-9661
AD  - Department of Urology, First Affiliated Hospital of Anhui Medical University, 
      Hefei, China.
FAU - Gao, Jingjing
AU  - Gao J
AD  - Department of Urology, First Affiliated Hospital of Anhui Medical University, 
      Hefei, China.
FAU - Gao, Pan
AU  - Gao P
AD  - Department of Urology, First Affiliated Hospital of Anhui Medical University, 
      Hefei, China.
FAU - Peng, Dangwei
AU  - Peng D
AD  - Department of Urology, First Affiliated Hospital of Anhui Medical University, 
      Hefei, China.
FAU - Dai, Yutian
AU  - Dai Y
AD  - Department of Andrology, Affiliated Drum Tower Hospital, School of Medicine, 
      Nanjing University, Nanjing, China.
FAU - Jiang, Hui
AU  - Jiang H
AD  - Department of Andrology, Peking University Third Hospital, Beijing, China.
AD  - Department of Human Sperm Bank, Peking University Third Hospital, Beijing, China.
FAU - Zhang, Xiansheng
AU  - Zhang X
AUID- ORCID: 0000-0001-6003-5182
AD  - Department of Urology, First Affiliated Hospital of Anhui Medical University, 
      Hefei, China.
LA  - eng
GR  - 82071637/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20210612
PL  - Germany
TA  - Andrologia
JT  - Andrologia
JID - 0423506
RN  - 0 (Benzylamines)
RN  - 0 (Naphthalenes)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - GB2433A4M3 (dapoxetine)
SB  - IM
MH  - Benzylamines
MH  - China
MH  - Ejaculation
MH  - Humans
MH  - Male
MH  - Naphthalenes
MH  - Polymorphism, Genetic
MH  - *Premature Ejaculation/drug therapy/genetics
MH  - *Serotonin Plasma Membrane Transport Proteins/genetics
MH  - Selective Serotonin Reuptake Inhibitors/therapeutic use
MH  - Treatment Outcome
OTO - NOTNLM
OT  - dapoxetine
OT  - polymorphism
OT  - premature ejaculation
OT  - serotonin transporter
EDAT- 2021/06/13 06:00
MHDA- 2021/08/12 06:00
CRDT- 2021/06/12 12:13
PHST- 2021/05/13 00:00 [revised]
PHST- 2021/02/02 00:00 [received]
PHST- 2021/05/21 00:00 [accepted]
PHST- 2021/06/13 06:00 [pubmed]
PHST- 2021/08/12 06:00 [medline]
PHST- 2021/06/12 12:13 [entrez]
AID - 10.1111/and.14141 [doi]
PST - ppublish
SO  - Andrologia. 2021 Sep;53(8):e14141. doi: 10.1111/and.14141. Epub 2021 Jun 12.