PMID- 34118175 OWN - NLM STAT- MEDLINE DCOM- 20210826 LR - 20231107 IS - 1708-8208 (Electronic) IS - 1523-0899 (Print) IS - 1523-0899 (Linking) VI - 23 IP - 4 DP - 2021 Aug TI - Efficacy of bone-substitute materials use in immediate dental implant placement: A systematic review and meta-analysis. PG - 506-519 LID - 10.1111/cid.13014 [doi] AB - OBJECTIVE: To assess the efficacy of using a bone substitute material (BSM) in the fixture-socket gap in patients undergoing tooth extraction and immediate implant placement. MATERIALS AND METHODS: MEDLINE, EMBASE, and CENTRAL databases were searched for randomized controlled trials (RCTs). RCTs were screened for eligibility, and data were extracted by two authors independently. Risk of bias (ROB) was assessed using Cochrane's ROB tool 2.0. Primary outcomes were implant failure, overall complications, and soft-tissue esthetics. Secondary outcomes were vertical buccal bone resorption, vertical interproximal bone resorption, horizontal buccal bone resorption, and mid-buccal mucosal recession. Meta-analysis was performed using random-effects model with generic inverse variance weighing. GRADE was used to grade the certainty of the evidence. RESULTS: After screening 19 544 potentially eligible references, 20 RCTs were included in this review, with a total of 848 patients (916 sites). Most included RCTs were deemed of some concerns (53%) or at low (38%) risk of bias, except for overall complications (high ROB). Implant failure did not differ significantly RR = 0.92 (confidence intervals [CI] 0.34 to 2.46) between using a BSM compared with not using a BSM (NoBSM). BSM use resulted in less horizontal buccal bone resorption (MD = -0.52 mm [95% CI -0.74 to -0.30]), a higher esthetic score (MD = 1.49 [95% CI 0.46 to 2.53]), but also more complications (RR = 3.50 [95% CI 1.11 to 11.1] compared with NoBSM. Too few trials compared types of BSMs against each other to allow for pooled analyses. The certainty of the evidence was considered moderate for all outcomes except implant failure (low), overall complications (very low), and vertical interproximal bone resorption (very low). CONCLUSION: BSM use during immediate implant placement reduces horizontal buccal bone resorption and improves the periimplant soft-tissue esthetics. Although BSM use increases the risk of predominantly minor complications. CI - (c) 2021 The Authors. Clinical Implant Dentistry and Related Research Published by Wiley Periodicals LLC. FAU - Zaki, John AU - Zaki J AUID- ORCID: 0000-0003-2180-4094 AD - Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. AD - Maidan Dental Clinic, Kuwait. FAU - Yusuf, Nermin AU - Yusuf N AD - Department of Periodontology, Faculty of Dentistry, Cairo University, Giza, Egypt. FAU - El-Khadem, Ahmed AU - El-Khadem A AD - The Centre for Evidence-Based Dentistry, Faculty of Dentistry, Cairo University, Giza, Egypt. AD - Department of Pediatric Dentistry, Faculty of Dentistry, Cairo University, Giza, Egypt. FAU - Scholten, Rob J P M AU - Scholten RJPM AD - Cochrane Netherlands and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. AD - Cochrane Netherlands, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. FAU - Jenniskens, Kevin AU - Jenniskens K AD - Cochrane Netherlands and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20210612 PL - United States TA - Clin Implant Dent Relat Res JT - Clinical implant dentistry and related research JID - 100888977 RN - 0 (Bone Substitutes) RN - 0 (Dental Implants) SB - IM MH - *Bone Substitutes MH - Dental Implantation, Endosseous/adverse effects MH - *Dental Implants/adverse effects MH - Esthetics, Dental MH - Humans MH - Tooth Extraction PMC - PMC8453723 OTO - NOTNLM OT - bone regeneration OT - bone substitutes OT - dental implant OT - tooth extraction OT - tooth socket COIS- The authors declare no conflicts of interest. EDAT- 2021/06/13 06:00 MHDA- 2021/08/27 06:00 PMCR- 2021/09/21 CRDT- 2021/06/12 17:06 PHST- 2021/03/25 00:00 [revised] PHST- 2020/12/16 00:00 [received] PHST- 2021/04/29 00:00 [accepted] PHST- 2021/06/13 06:00 [pubmed] PHST- 2021/08/27 06:00 [medline] PHST- 2021/06/12 17:06 [entrez] PHST- 2021/09/21 00:00 [pmc-release] AID - CID13014 [pii] AID - 10.1111/cid.13014 [doi] PST - ppublish SO - Clin Implant Dent Relat Res. 2021 Aug;23(4):506-519. doi: 10.1111/cid.13014. Epub 2021 Jun 12.