PMID- 34118238
OWN - NLM
STAT- MEDLINE
DCOM- 20210720
LR  - 20210720
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 520
DP  - 2021 Sep
TI  - Atopic respiratory diseases and IgE sensitization are associated with leukocyte 
      subset concentrations in 14,440 blood donors.
PG  - 139-146
LID - S0009-8981(21)00216-3 [pii]
LID - 10.1016/j.cca.2021.06.015 [doi]
AB  - BACKGROUND AND AIMS: Allergic rhinitis (AR), allergic conjunctivitis (AC), and 
      asthma are characterized by activation of the immune system. The aim of this 
      study was to explore the long-term association between AR, AC, asthma, and 
      specific immunoglobulin E (IgE) and blood platelet and leukocyte differential 
      counts. MATERIAL AND METHODS: In the Danish Blood Donor Study, 14,440 
      participants from Central Denmark Region had platelet and leukocyte differential 
      counts available and completed a questionnaire regarding AR, AC, and asthma. Of 
      these participants, 8485 were tested for IgE to inhalation allergens. RESULTS: 
      The prevalence of AR, AC, asthma, and IgE sensitization was 19%, 15%, 9%, and 
      29%, respectively. AR, AC, asthma, wheeze, and IgE sensitization was associated 
      with increased blood eosinophil concentration even in IgE sensitized participants 
      who did not report any allergy or asthma. The strongest associations were 
      observed for participants with current disease. We found no differences in 
      eosinophil concentration between months without symptoms and months with symptoms 
      of AR and asthma. CONCLUSION: AR, AC, asthma, wheezing, and IgE sensitization to 
      inhalation allergens are associated with increased eosinophil concentration. This 
      may reflect a persistent inflammation even in periods without symptomatic 
      disease.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Mikkelsen, Susan
AU  - Mikkelsen S
AD  - Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark. 
      Electronic address: susanmke@rm.dk.
FAU - Boldsen, Jens Kjaergaard
AU  - Boldsen JK
AD  - Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark; 
      Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University, 
      DK-4000 Roskilde, Denmark.
FAU - Moller, Bjarne Kuno
AU  - Moller BK
AD  - Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
FAU - Dinh, Khoa Manh
AU  - Dinh KM
AD  - Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
FAU - Rostgaard, Klaus
AU  - Rostgaard K
AD  - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
FAU - Petersen, Mikkel Steen
AU  - Petersen MS
AD  - Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
FAU - Kaspersen, Kathrine Agergard
AU  - Kaspersen KA
AD  - Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark; 
      Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University, 
      DK-4000 Roskilde, Denmark.
FAU - Pedersen, Ole Birger
AU  - Pedersen OB
AD  - Department of Clinical Immunology, Zealand University Hospital, Koge, Denmark.
FAU - Thorner, Lise Wegner
AU  - Thorner LW
AD  - Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, 
      Denmark.
FAU - Handgaard, Linda Jenny
AU  - Handgaard LJ
AD  - Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, 
      Denmark.
FAU - Ostrowski, Sisse Rye
AU  - Ostrowski SR
AD  - Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, 
      Denmark.
FAU - Sigsgaard, Torben
AU  - Sigsgaard T
AD  - Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University, 
      DK-4000 Roskilde, Denmark; Department of Public Health, Aarhus University, 
      Aarhus, Denmark.
FAU - Erikstrup, Christian
AU  - Erikstrup C
AD  - Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark; 
      Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University, 
      DK-4000 Roskilde, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20210609
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens
MH  - Blood Donors
MH  - Eosinophils
MH  - Humans
MH  - *Hypersensitivity, Immediate/epidemiology
MH  - Immunoglobulin E
MH  - *Rhinitis, Allergic
OTO - NOTNLM
OT  - Allergic IgE sensitization
OT  - Allergic conjunctivitis
OT  - Allergic rhinitis
OT  - Asthma
OT  - Peripheral blood leukocytes
OT  - Platelets
EDAT- 2021/06/13 06:00
MHDA- 2021/07/21 06:00
CRDT- 2021/06/12 20:08
PHST- 2021/04/18 00:00 [received]
PHST- 2021/06/07 00:00 [revised]
PHST- 2021/06/07 00:00 [accepted]
PHST- 2021/06/13 06:00 [pubmed]
PHST- 2021/07/21 06:00 [medline]
PHST- 2021/06/12 20:08 [entrez]
AID - S0009-8981(21)00216-3 [pii]
AID - 10.1016/j.cca.2021.06.015 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2021 Sep;520:139-146. doi: 10.1016/j.cca.2021.06.015. Epub 2021 
      Jun 9.