PMID- 34118642 OWN - NLM STAT- MEDLINE DCOM- 20220203 LR - 20220203 IS - 1873-5126 (Electronic) IS - 1353-8020 (Linking) VI - 88 DP - 2021 Jul TI - Retinal thickness and microvascular pathway in Idiopathic Rapid eye movement sleep behaviour disorder and Parkinson's disease. PG - 40-45 LID - S1353-8020(21)00203-0 [pii] LID - 10.1016/j.parkreldis.2021.05.031 [doi] AB - INTRODUCTION: Retinal impairment has previously been described in Parkinson's Disease (PD), also in early stage of disease. Idiopathic Rapid-eye-movement sleep Behavior Disorder (iRBD) is considered the strongest marker in the diagnosis of "Prodromal PD". Thus, we evaluated the thickness of retinal layers and the microvascular retinal pattern in a group of iRBD patients compared to PD and healthy subjects (HCs). METHODS: retinal layer's thickness and microvascular pattern among PD, iRBD and HCs were assessed using Spectral-Density Optical Coherence Tomography (SD-OCT) and OCT-Angiography (OCT-A), respectively. RESULTS: Forty-one eyes from 21 PD, 37 eyes from 19 iRBD and 33 eyes from 17 HCs were analysed. Peripapillary Retinal Nerve Fiber Layer (RNFL) was thinner in PD and RBD compared to HCs. All macular retinal layers, except for retinal pigment epithelium, resulted to be significantly thinner in iRBD and in PD compared to HCs, also adjusting by age, sex and hypertension. Macular RNFL and ganglionic cell layer were thinner in PD compared to iRBD. Moreover, in iRBD, a peculiar microvascular pattern was found, characterized by a higher vascularization of the deep capillary plexus with respect both PD patients and HCs. CONCLUSION: in PD and iRBD patients retina was thinner than HCs, and values of iRBD were between PD and HCs. Moreover, in iRBD, a peculiar microvascular pattern has been found, characterized by a higher vascularization of the deep capillary plexus. Our findings suggest that retina might be considered a biomarker of neurodegeneration in iRBD, easily estimable using non-invasive tool such as OCT and OCT-A. CI - Copyright (c) 2021 Elsevier Ltd. All rights reserved. FAU - Rascuna, Cristina AU - Rascuna C AD - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, Section of Neurosciences, University of Catania, Catania, CT, Italy. Electronic address: cristiras90@gmail.com. FAU - Cicero, Calogero Edoardo AU - Cicero CE AD - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, Section of Neurosciences, University of Catania, Catania, CT, Italy. Electronic address: edoardo.cicero@gmail.com. FAU - Chisari, Clara Grazia AU - Chisari CG AD - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, Section of Neurosciences, University of Catania, Catania, CT, Italy. Electronic address: clarachisari@yahoo.it. FAU - Russo, Andrea AU - Russo A AD - Department of Ophthalmology, University of Catania, Catania, CT, Italy. Electronic address: andrearusso2000@hotmail.com. FAU - Giuliano, Loretta AU - Giuliano L AD - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, Section of Neurosciences, University of Catania, Catania, CT, Italy. Electronic address: giuliano.loretta@gmail.com. FAU - Castellino, Niccolo AU - Castellino N AD - Department of Ophthalmology, University of Catania, Catania, CT, Italy. Electronic address: ncastellino7@gmail.com. FAU - Terravecchia, Claudio AU - Terravecchia C AD - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, Section of Neurosciences, University of Catania, Catania, CT, Italy. Electronic address: claudioterravecchia@gmail.com. FAU - Grillo, Marco AU - Grillo M AD - Department of Ophthalmology, University of Catania, Catania, CT, Italy. Electronic address: drmarcogrillo@gmail.com. FAU - Longo, Antonio AU - Longo A AD - Department of Ophthalmology, University of Catania, Catania, CT, Italy. Electronic address: antlongo@unict.it. FAU - Avitabile, Teresio AU - Avitabile T AD - Department of Ophthalmology, University of Catania, Catania, CT, Italy. Electronic address: t.avitabile@unict.it. FAU - Zappia, Mario AU - Zappia M AD - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, Section of Neurosciences, University of Catania, Catania, CT, Italy. Electronic address: m.zappia@unict.it. FAU - Reibaldi, Michele AU - Reibaldi M AD - Department of Ophthalmology, University of Catania, Catania, CT, Italy. Electronic address: mreibaldi@libero.it. FAU - Nicoletti, Alessandra AU - Nicoletti A AD - Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, Section of Neurosciences, University of Catania, Catania, CT, Italy. Electronic address: anicolet@unict.it. LA - eng PT - Journal Article DEP - 20210606 PL - England TA - Parkinsonism Relat Disord JT - Parkinsonism & related disorders JID - 9513583 RN - 0 (Biomarkers) SB - IM MH - Aged MH - Biomarkers MH - Female MH - Humans MH - Male MH - Middle Aged MH - Parkinson Disease/diagnostic imaging/*pathology MH - REM Sleep Behavior Disorder/diagnostic imaging/*pathology MH - Retinal Diseases/diagnostic imaging/*pathology MH - Retinal Vessels/diagnostic imaging/*pathology MH - Tomography, Optical Coherence OTO - NOTNLM OT - Idiopathic rapid eye movement sleep behaviour disorder (iRBD) OT - Neurodegeneration OT - Optical coherence tomography (OCT) OT - Parkinson's disease OT - Retina OT - Vascularization EDAT- 2021/06/13 06:00 MHDA- 2022/02/04 06:00 CRDT- 2021/06/12 20:18 PHST- 2020/12/04 00:00 [received] PHST- 2021/05/23 00:00 [revised] PHST- 2021/05/28 00:00 [accepted] PHST- 2021/06/13 06:00 [pubmed] PHST- 2022/02/04 06:00 [medline] PHST- 2021/06/12 20:18 [entrez] AID - S1353-8020(21)00203-0 [pii] AID - 10.1016/j.parkreldis.2021.05.031 [doi] PST - ppublish SO - Parkinsonism Relat Disord. 2021 Jul;88:40-45. doi: 10.1016/j.parkreldis.2021.05.031. Epub 2021 Jun 6.