PMID- 34119408
OWN - NLM
STAT- MEDLINE
DCOM- 20220310
LR  - 20220310
IS  - 1096-3634 (Electronic)
IS  - 1084-9521 (Linking)
VI  - 121
DP  - 2022 Jan
TI  - Nonclassical androgen and estrogen signaling is essential for normal 
      spermatogenesis.
PG  - 71-81
LID - S1084-9521(21)00147-6 [pii]
LID - 10.1016/j.semcdb.2021.05.032 [doi]
AB  - Signaling by androgens through androgen receptor (AR) is essential to complete 
      spermatogenesis in the testis. Similarly, loss of the main estrogen receptor, 
      estrogen receptor 1 (ESR1; also known as ERalpha), results in male infertility, due 
      in part to indirect deleterious effects on the seminiferous epithelium and 
      spermatogenesis. Effects of steroid hormones are induced primarily through 
      genomic changes induced by hormone-mediated activation of their intracellular 
      receptors and subsequent effects on nuclear gene transcription. However, 
      androgens and estrogens also signal through rapid nonclassical pathways involving 
      actions initiated at the cell membrane. Here we review the data that nonclassical 
      androgen and estrogen signaling pathways support processes essential for male 
      fertility in the testis and reproductive tract. The recent development of 
      transgenic mice lacking nonclassical AR or ESR1 signaling but retaining genomic 
      nuclear signaling has provided a powerful tool to elucidate the function of 
      nonclassical signaling in the overall response to androgens and estrogens. 
      Results from these mice have emphasized that nonclassical signaling is essential 
      for full responses to these hormones, and absence of either nonclassical or 
      classical AR or ESR1 pathways produces abnormalities in spermatogenesis and the 
      male reproductive tract. Although additional work is required to fully understand 
      how classical and nonclassical receptor signaling synergize to produce full 
      steroid hormone responses, here we summarize the known physiological functions of 
      the classical and nonclassical androgen and estrogen signaling pathways in the 
      testis and reproductive tract.
CI  - Copyright (c) 2021. Published by Elsevier Ltd.
FAU - Cooke, Paul S
AU  - Cooke PS
AD  - Department of Physiological Sciences, University of Florida, Gainesville, FL 
      32610, USA. Electronic address: paulscooke@ufl.edu.
FAU - Walker, William H
AU  - Walker WH
AD  - Department of Obstetrics, Gynecology and Reproductive Sciences, University of 
      Pittsburgh School of Medicine and Magee-Womens Research Institute, Pittsburgh, PA 
      15213, USA. Electronic address: walkerw@pitt.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210609
PL  - England
TA  - Semin Cell Dev Biol
JT  - Seminars in cell & developmental biology
JID - 9607332
RN  - 0 (Androgens)
RN  - 0 (Estrogens)
SB  - IM
MH  - Androgens/*metabolism
MH  - Animals
MH  - Estrogens/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Spermatogenesis/*genetics
OTO - NOTNLM
OT  - Efferent ductules
OT  - Rete testis
OT  - Sertoli cell
OT  - Sperm
OT  - Steroid hormone receptors
OT  - Testis
EDAT- 2021/06/14 06:00
MHDA- 2022/03/11 06:00
CRDT- 2021/06/13 20:34
PHST- 2021/01/20 00:00 [received]
PHST- 2021/05/25 00:00 [revised]
PHST- 2021/05/31 00:00 [accepted]
PHST- 2021/06/14 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
PHST- 2021/06/13 20:34 [entrez]
AID - S1084-9521(21)00147-6 [pii]
AID - 10.1016/j.semcdb.2021.05.032 [doi]
PST - ppublish
SO  - Semin Cell Dev Biol. 2022 Jan;121:71-81. doi: 10.1016/j.semcdb.2021.05.032. Epub 
      2021 Jun 9.