PMID- 34119651
OWN - NLM
STAT- MEDLINE
DCOM- 20210924
LR  - 20211204
IS  - 1879-1107 (Electronic)
IS  - 1096-4959 (Linking)
VI  - 256
DP  - 2021 Oct-Dec
TI  - Review: Schistosoma mansoni phosphatidylinositol 3 kinase (PI3K)/Akt/mechanistic 
      target of rapamycin (mTOR) signaling pathway.
PG  - 110632
LID - S1096-4959(21)00071-3 [pii]
LID - 10.1016/j.cbpb.2021.110632 [doi]
AB  - Schistosoma mansoni worms are under a milieu of external and internal signaling 
      pathways. The life-cycle stages are exposed to enormous stimuli within the 
      mammalian and the snail hosts and as free-living stages in the fresh water. 
      Furthermore, there is a unique interplay between the male and the female worms 
      involving many stimuli from the male essential for full development of the 
      female. PI3K/Akt/mTOR is an evolutionarily divergent signal transduction pathway 
      universal to nearly every multicellular organism. This work reviews the 
      Schistosoma mansoni PI3K/Akt/mTOR signal pathways and the involvement of the 
      signal in the worms' physiology concerning the uptake of glucose, reproduction 
      and survival. The inhibitors of the signal pathway used against Schistosoma 
      mansoni were summarized. Given the importance of the PI3K/Akt/mTOR signal 
      pathway, its inhibition could be a promising control strategy against 
      schistosomiasis.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Abou-El-Naga, Iman F
AU  - Abou-El-Naga IF
AD  - Medical Parasitology Department, Faculty of Medicine, Alexandria University, 12 
      Abdel Hamid El Deeb Street, Tharwat, Alexandria, Egypt. Electronic address: 
      imanabouelnaga@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210610
PL  - England
TA  - Comp Biochem Physiol B Biochem Mol Biol
JT  - Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
JID - 9516061
RN  - EC 2.7.1.137 (Phosphatidylinositol 3-Kinase)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Phosphatidylinositol 3-Kinase/*metabolism
MH  - Proto-Oncogene Proteins c-akt/*metabolism
MH  - Schistosoma mansoni/*physiology
MH  - Schistosomiasis mansoni/*metabolism/parasitology
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
OTO - NOTNLM
OT  - Glucose uptake
OT  - Protein kinases
OT  - Receptors
OT  - Reproduction
OT  - Schistosoma
EDAT- 2021/06/14 06:00
MHDA- 2021/09/25 06:00
CRDT- 2021/06/13 20:41
PHST- 2021/02/12 00:00 [received]
PHST- 2021/04/19 00:00 [revised]
PHST- 2021/06/07 00:00 [accepted]
PHST- 2021/06/14 06:00 [pubmed]
PHST- 2021/09/25 06:00 [medline]
PHST- 2021/06/13 20:41 [entrez]
AID - S1096-4959(21)00071-3 [pii]
AID - 10.1016/j.cbpb.2021.110632 [doi]
PST - ppublish
SO  - Comp Biochem Physiol B Biochem Mol Biol. 2021 Oct-Dec;256:110632. doi: 
      10.1016/j.cbpb.2021.110632. Epub 2021 Jun 10.