PMID- 34119776
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20221207
IS  - 1879-2219 (Electronic)
IS  - 0966-6362 (Linking)
VI  - 88
DP  - 2021 Jul
TI  - Minimal clinically important difference in walking velocity, gait profile score 
      and two minute walk test for individuals with lower limb amputation.
PG  - 221-224
LID - S0966-6362(21)00216-2 [pii]
LID - 10.1016/j.gaitpost.2021.06.001 [doi]
AB  - BACKGROUND: Individuals with lower limb amputation are routinely assessed with a 
      variety outcome measures, however there is a lack of published data to indicate 
      minimal clinically important differences (MCID) for many of these outcome 
      measures. Three such important gait-specific outcome measures include walking 
      velocity, gait profile score (GPS) and the two minute walk test (2MWT). RESEARCH 
      QUESTION: Determine the MCIDs for walking velocity, GPS and 2MWT for individuals 
      with lower limb amputation. METHODS: Walking velocity and GPS (n = 60), and 2MWT 
      (n = 119) data for individuals with unilateral transfemoral or knee 
      disarticulation were identified retrospectively from a database held at the study 
      centre. An anchor-based method was used with Medicare functional classification 
      level (MFCL) acting as the impairment-related criterion, and a least-squares 
      linear regression approach was used to calculate the gradient required for a 
      change between MFCL levels. RESULTS: An increase of 0.21 m/s (95 % CI: 0.13,0.29) 
      for walking velocity, a reduction of 1.7 degrees  (95 % CI: -2.449,-1.097) for GPS and an 
      increase of 37.2 m (95 % CI: 28.8,45.5) for 2MWT were found to correspond to an 
      increase in MFCL of one level. Walking velocity, GPS and 2MWT correlated with 
      MFCL with R(2) values of 0.333, 0.322 and 0.398 respectively (p < 0.00001). The 
      authors propose that 0.21 m/s for walking velocity, 1.7 degrees  for GPS and 37.2 m for 
      2MWT be used as MCID values for individuals with lower limb amputation. 
      SIGNIFICANCE: The results of this study can be used to help both researchers and 
      clinicians to objectively evaluate if interventions for individuals with lower 
      limb amputation are effective.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Carse, Bruce
AU  - Carse B
AD  - West of Scotland Rehabilitation and Mobility Centre, Queen Elizabeth University 
      Hospital, NHS Greater Glasgow and Clyde, 1345 Govan Road, Glasgow, G51 4TF, UK. 
      Electronic address: bruce.carse@ggc.scot.nhs.uk.
FAU - Scott, Helen
AU  - Scott H
AD  - West of Scotland Rehabilitation and Mobility Centre, Queen Elizabeth University 
      Hospital, NHS Greater Glasgow and Clyde, 1345 Govan Road, Glasgow, G51 4TF, UK.
FAU - Davie-Smith, Fiona
AU  - Davie-Smith F
AD  - West of Scotland Rehabilitation and Mobility Centre, Queen Elizabeth University 
      Hospital, NHS Greater Glasgow and Clyde, 1345 Govan Road, Glasgow, G51 4TF, UK.
FAU - Brady, Laura
AU  - Brady L
AD  - West of Scotland Rehabilitation and Mobility Centre, Queen Elizabeth University 
      Hospital, NHS Greater Glasgow and Clyde, 1345 Govan Road, Glasgow, G51 4TF, UK.
FAU - Colvin, John
AU  - Colvin J
AD  - West of Scotland Rehabilitation and Mobility Centre, Queen Elizabeth University 
      Hospital, NHS Greater Glasgow and Clyde, 1345 Govan Road, Glasgow, G51 4TF, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210610
PL  - England
TA  - Gait Posture
JT  - Gait & posture
JID - 9416830
SB  - IM
MH  - Aged
MH  - Amputation, Surgical
MH  - *Amputees
MH  - *Artificial Limbs
MH  - Gait
MH  - Humans
MH  - Lower Extremity
MH  - Medicare
MH  - Minimal Clinically Important Difference
MH  - Retrospective Studies
MH  - United States
MH  - Walk Test
MH  - Walking
OTO - NOTNLM
OT  - Gait
OT  - Gait profile score
OT  - Lower limb amputation
OT  - Minimal clinically important difference
OT  - Prosthetic
OT  - Walking velocity
EDAT- 2021/06/14 06:00
MHDA- 2021/11/26 06:00
CRDT- 2021/06/13 20:45
PHST- 2020/11/06 00:00 [received]
PHST- 2021/05/31 00:00 [revised]
PHST- 2021/06/02 00:00 [accepted]
PHST- 2021/06/14 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2021/06/13 20:45 [entrez]
AID - S0966-6362(21)00216-2 [pii]
AID - 10.1016/j.gaitpost.2021.06.001 [doi]
PST - ppublish
SO  - Gait Posture. 2021 Jul;88:221-224. doi: 10.1016/j.gaitpost.2021.06.001. Epub 2021 
      Jun 10.