PMID- 34122050
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210615
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 13
DP  - 2021
TI  - Right Frontoinsular Cortex: A Potential Imaging Biomarker to Evaluate 
      T2DM-Induced Cognitive Impairment.
PG  - 674288
LID - 10.3389/fnagi.2021.674288 [doi]
LID - 674288
AB  - Cognitive impairment in type 2 diabetes mellitus (T2DM) is associated with 
      functional and structural abnormalities in the intrinsic brain network. The 
      salience network (SN) is a neurocognitive network that maintains normal cognitive 
      function, but it has received little attention in T2DM. We explored SN changes in 
      patients with T2DM with normal cognitive function (DMCN) and in patients with 
      T2DM with mild cognitive impairment (DMCI). Sixty-five T2DM patients and 31 
      healthy controls (HCs) underwent a neuropsychological assessment, independent 
      component analysis (ICA), and voxel-based morphometry (VBM) analysis. The ICA 
      extracted the SN for VBM to compare SN functional connectivity (FC) and gray 
      matter (GM) volume (GMV) between groups. A correlation analysis examined the 
      relationship between abnormal FC and GMV and clinical/cognitive variables. 
      Compared with HCs, DMCN patients demonstrated increased FC in the left 
      frontoinsular cortex (FIC), right anterior insula, and putamen, while DMCI 
      patients demonstrated decreased right middle/inferior frontal gyrus FC. Compared 
      with DMCN patients, DMCI patients showed decreased right FIC FC. There was no 
      significant difference in SN GMV in DMCN and DMCI patients compared with HCs. FIC 
      GMV was decreased in the DMCI patients compared with DMCN patients. In addition, 
      right FIC FC and SN GMV positively correlated with Montreal Cognitive Assessment 
      and Mini-Mental State Examination (MMSE) scores. These findings indicate that 
      changes in SN FC, and GMV are complex non-linear processes accompanied by 
      increased cognitive dysfunction in patients with T2DM. The right FIC may be a 
      useful imaging biomarker for supplementary assessment of early cognitive 
      dysfunction in patients with T2DM.
CI  - Copyright (c) 2021 Zhang, Lei, Gao, Qi, Yan, Ai, Zhe, Cheng, Wang, Su, Tang and 
      Zhang.
FAU - Zhang, Dongsheng
AU  - Zhang D
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Lei, Yumeng
AU  - Lei Y
AD  - Department of Graduate, Xi'an Medical University, Xi'an, China.
FAU - Gao, Jie
AU  - Gao J
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Qi, Fei
AU  - Qi F
AD  - Department of Graduate, Xi'an Medical University, Xi'an, China.
FAU - Yan, Xuejiao
AU  - Yan X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Ai, Kai
AU  - Ai K
AD  - Department of Clinical Science, Philips Healthcare, Xi'an, China.
FAU - Zhe, Xia
AU  - Zhe X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Cheng, Miao
AU  - Cheng M
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Wang, Man
AU  - Wang M
AD  - Department of Graduate, Xi'an Medical University, Xi'an, China.
FAU - Su, Yu
AU  - Su Y
AD  - Department of Graduate, Xi'an Medical University, Xi'an, China.
FAU - Tang, Min
AU  - Tang M
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Zhang, Xiaoling
AU  - Zhang X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
LA  - eng
PT  - Journal Article
DEP - 20210528
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC8193040
OTO - NOTNLM
OT  - independent component analysis
OT  - neuroimaging
OT  - salience network
OT  - type 2 diabetes mellitus
OT  - voxel-based morphometry
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/06/15 06:00
MHDA- 2021/06/15 06:01
PMCR- 2021/01/01
CRDT- 2021/06/14 09:35
PHST- 2021/03/01 00:00 [received]
PHST- 2021/04/27 00:00 [accepted]
PHST- 2021/06/14 09:35 [entrez]
PHST- 2021/06/15 06:00 [pubmed]
PHST- 2021/06/15 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2021.674288 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2021 May 28;13:674288. doi: 10.3389/fnagi.2021.674288. 
      eCollection 2021.