PMID- 34122584
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210615
IS  - 1735-3955 (Print)
IS  - 2251-6638 (Electronic)
IS  - 1735-3955 (Linking)
VI  - 16
IP  - 6
DP  - 2020 Nov
TI  - Rationale, design, and preliminary results of the Iran-premature coronary artery 
      disease study (I-PAD): A multi-center case-control study of different Iranian 
      ethnicities.
PG  - 295-300
LID - 10.22122/arya.v16i6.2241 [doi]
AB  - BACKGROUND: Premature coronary artery disease (CAD) is still prevalent worldwide 
      and may differ in various ethnicities. Due to the presence of different 
      ethnicities in Iran, the Iran-premature coronary artery disease (I-PAD) study 
      aimed to determine the frequency of premature CAD and related risk factors based 
      on each ethnicity. METHODS: In this multi-center case-control study, 4000 
      patients with premature CAD from ten different ethnicities who lived in different 
      cities of Iran and underwent coronary angiography were enrolled (women aged </= 70 
      and men </= 60 years). Patients with CAD defined as obstruction equal or above 75% 
      in at least a single coronary artery or left main >/= 50% were included in the case 
      group, while patients with normal coronary arteries were included in the control 
      group. Lifestyle behaviors, cardiometabolic risk factors, anthropometric 
      measurements, and other variables were collected. Serum, whole blood, buffy coat, 
      plasma, urine, stool, and saliva samples were stored. RESULTS: The number of 
      patients enrolled until April 2020 was 2071. The mean age of patients was 53.51 +/- 
      7.52 and 934 (45.09%) of patients were women. To date, about 39.6% of the 
      patients were normal. Also, about 26.0% were with one-vessel disease (1VD), 15.0% 
      with two-vessel disease (2VD), and 15.2% with three-vessel disease (3VD). More 
      than 30000 patients' biosamples from across the country have been stored. 
      CONCLUSION: Knowing the frequency of premature CAD according to different 
      ethnicities with major differences in their lifestyle behaviors and risk factors 
      can assist health decision-makers. In addition, I-PAD biosamples will be an 
      invaluable source.
CI  - (c) 2020 Isfahan Cardiovascular Research Center & Isfahan University of Medical 
      Sciences.
FAU - Zarepur, Ehsan
AU  - Zarepur E
AD  - Resident, Interventional Cardiology Research Center, Cardiovascular Research 
      Institute AND Department of Cardiology, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
FAU - Mohammadifard, Noushin
AU  - Mohammadifard N
AD  - Assistant Professor, Isfahan Cardiovascular Research Center, Cardiovascular 
      Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Mansourian, Marjan
AU  - Mansourian M
AD  - Associate Professor, Pediatric Cardiovascular Research Center, Cardiovascular 
      Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Roohafza, Hamidreza
AU  - Roohafza H
AD  - Assistant Professor, Isfahan Cardiovascular Research Center, Cardiovascular 
      Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Sadeghi, Masoumeh
AU  - Sadeghi M
AD  - Professor, Cardiac Rehabilitation Research Center, Cardiovascular Research 
      Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Khosravi, Alireza
AU  - Khosravi A
AD  - Professor, Hypertension Research Center, Cardiovascular Research Institute, 
      Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Nouri, Fatemeh
AU  - Nouri F
AD  - Heart Failure Research Center, Cardiovascular Research Institute, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
FAU - Azdaki, Nahid
AU  - Azdaki N
AD  - Associate Professor, Cardiovascular Diseases Research Center AND Razi Clinical 
      Research Development Unit, Birjand University of Medical Sciences, Birjand, Iran.
FAU - Salehi, Nahid
AU  - Salehi N
AD  - Associate Professor, Cardiovascular Research Center, Health Institute, Kermanshah 
      University of Medical Sciences, Kermanshah, Iran.
FAU - Lotfizadeh, Masoud
AU  - Lotfizadeh M
AD  - Associate Professor, Social Determinants of Health Research Center, Shahrekord 
      University of Medical Sciences, Shahrekord, Iran.
FAU - Sarrafzadegan, Nizal
AU  - Sarrafzadegan N
AD  - Professor, Isfahan Cardiovascular Research Center, Cardiovascular Research 
      Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
AD  - Professor, Faculty of Medicine, School of Population and Public Health, 
      University of British Columbia, Vancouver, Canada.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - ARYA Atheroscler
JT  - ARYA atherosclerosis
JID - 101487337
PMC - PMC8172231
OTO - NOTNLM
OT  - Biological Specimen Banks
OT  - Coronary Artery Disease
OT  - Ethnic Groups
OT  - Iran
OT  - Risk Factors
EDAT- 2021/06/15 06:00
MHDA- 2021/06/15 06:01
PMCR- 2020/11/01
CRDT- 2021/06/14 09:38
PHST- 2021/06/14 09:38 [entrez]
PHST- 2021/06/15 06:00 [pubmed]
PHST- 2021/06/15 06:01 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - ARYA-16-295 [pii]
AID - 10.22122/arya.v16i6.2241 [doi]
PST - ppublish
SO  - ARYA Atheroscler. 2020 Nov;16(6):295-300. doi: 10.22122/arya.v16i6.2241.