PMID- 34122773
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220423
IS  - 0019-5413 (Print)
IS  - 1998-3727 (Electronic)
IS  - 0019-5413 (Linking)
VI  - 55
IP  - Suppl 1
DP  - 2021 May
TI  - Efficacy of Autologous Conditioned Serum (ACS), Platelet-Rich Plasma (PRP), 
      Hyaluronic Acid (HA) and Steroid for Early Osteoarthritis Knee: A Comparative 
      Analysis.
PG  - 217-227
LID - 10.1007/s43465-020-00274-5 [doi]
AB  - BACKGROUND: Intra-articular injection therapy constituting corticosteroids, 
      viscosupplements and blood-derived products are considered to have a key role in 
      non-operative management of osteoarthritis knee. While corticosteroids and 
      viscosupplements have proven short-term efficacy in early osteoarthritis; 
      orthobiologics are gaining increased attention in osteoarthritis management. The 
      aim of present study was thus to compare two commonly used biologics 
      (platelet-rich plasma/PRP and autologous conditioned serum/ACS) to each other and 
      to established therapies. METHODS: After required institutional clearances, all 
      patients presenting with early primary osteoarthritis knee who had failed initial 
      conservative management and received only unilateral knee injection were 
      included. Patients in the PRP group were compared to the other groups (comprising 
      the HA/hyaluronic acid group, steroid group, and a matched cohort who had been 
      administered ACS for the same indication earlier). Clinical outcome was evaluated 
      using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) 
      questionnaire and Visual Analogue scale (VAS) pre-injection and at 6 months. 
      RESULTS: ACS and PRP did not have any significant difference in terms of either 
      WOMAC score (p = 0.154) or VAS score at 6 months (p = 0.850). The scores for both 
      these orthobiologics were better than the control groups (HA group and Steroid 
      group). Between the two control groups, HA group had better VAS scores as 
      compared to the Steroid group (p = 0.008). CONCLUSION: The clinical outcomes 
      following intra-articular injection of ACS and PRP are better than controls (HA 
      and steroid), but a difference between the two orthobiologics could not be 
      demonstrated. LEVEL OF EVIDENCE: 3b.
CI  - (c) Indian Orthopaedics Association 2020.
FAU - Khurana, Ankit
AU  - Khurana A
AUID- ORCID: 0000-0001-8397-6903
AD  - Department of Orthopaedics, Dr. BSA Medical College and Hospital, Rohini Sector 
      6, Delhi, 110009 India.
FAU - Goyal, Ashish
AU  - Goyal A
AD  - Department of Orthopaedics, Dr. BSA Medical College and Hospital, Rohini Sector 
      6, Delhi, 110009 India.
FAU - Kirubakaran, P
AU  - Kirubakaran P
AD  - Department of Orthopaedics, Evangelisches Krakenhaus, HansSachsGasse, Vienna, 
      Austria.
FAU - Akhand, Gaurav
AU  - Akhand G
AD  - Department of Orthopaedics, Dr. BSA Medical College and Hospital, Rohini Sector 
      6, Delhi, 110009 India.
FAU - Gupta, Rishi
AU  - Gupta R
AD  - Department of Biostatitics, Manokalp Clinic, Delhi, India.
FAU - Goel, Navneet
AU  - Goel N
AD  - Department of Orthopaedics, Dr. BSA Medical College and Hospital, Rohini Sector 
      6, Delhi, 110009 India.
LA  - eng
PT  - Journal Article
DEP - 20201008
PL  - Switzerland
TA  - Indian J Orthop
JT  - Indian journal of orthopaedics
JID - 0137736
PMC - PMC8149550
OTO - NOTNLM
OT  - Autologous conditioned serum (ACS)
OT  - Hyaluronan
OT  - Intra-articular injections
OT  - Osteoarthritis knee
OT  - Platelet-rich plasma (PRP)
COIS- Conflict of interestThe authors declare that they have no competing interests.
EDAT- 2021/06/15 06:00
MHDA- 2021/06/15 06:01
PMCR- 2021/10/08
CRDT- 2021/06/14 09:40
PHST- 2020/07/20 00:00 [received]
PHST- 2020/09/25 00:00 [accepted]
PHST- 2021/06/14 09:40 [entrez]
PHST- 2021/06/15 06:00 [pubmed]
PHST- 2021/06/15 06:01 [medline]
PHST- 2021/10/08 00:00 [pmc-release]
AID - 274 [pii]
AID - 10.1007/s43465-020-00274-5 [doi]
PST - epublish
SO  - Indian J Orthop. 2020 Oct 8;55(Suppl 1):217-227. doi: 10.1007/s43465-020-00274-5. 
      eCollection 2021 May.