PMID- 34124239
OWN - NLM
STAT- MEDLINE
DCOM- 20210922
LR  - 20230920
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2021
DP  - 2021
TI  - Importance of KIM-1 and MCP-1 in Determining the Leptospirosis-Associated AKI: A 
      Sri Lankan Study.
PG  - 1752904
LID - 10.1155/2021/1752904 [doi]
LID - 1752904
AB  - BACKGROUND: Acute kidney injury (AKI) is one of most prevalent and serious 
      complications of leptospirosis, a prevalent zoonotic disease in tropical 
      countries. Prompt diagnosis of the leptospirosis-associated AKI is a challenge as 
      there are no proper diagnostic tools that can identify patients in the early 
      stage. Kidney injury molecule-1 (KIM-1) and monocyte chemoattractant protein-1 
      (MCP-1) are widely used novel AKI biomarkers that are studied in various disease 
      conditions with AKI, but not in leptospirosis. Thus, this study is aimed at 
      seeking the importance of KIM-1 and MCP-1 in determining the 
      leptospirosis-associated AKI. METHODS: Leptospirosis-suspected patients who were 
      admitted to medical wards of two selected hospitals in the Western province of 
      Sri Lanka were recruited. Leptospirosis was confirmed by three diagnostic tests: 
      PCR, MAT, and culture, and the status of AKI was determined by Kidney Disease 
      Improving Global Outcomes (KDIGO) criteria. RESULTS: Of 170 
      leptospirosis-suspected patients, 79 were leptospirosis confirmed, and among 
      them, 24.05% of patients were diagnosed to have AKI according to KDIGO criteria. 
      Median serum KIM-1 (p < 0.0001), urine KIM-1 (0.0053), serum MCP-1 (0.0080), and 
      urine MCP-1 (0.0019) levels in those developing AKI were significantly higher 
      than in patients not developing AKI. The biomarker levels associated with 
      leptospirosis AKI had AUC-ROC of 0.8565, 0.7292, 0.7024, and 0.7282 for serum 
      KIM-1, urine KIM-1, serum MCP-1, and urine MCP-1, respectively. CONCLUSION: This 
      study revealed serum KIM-1 as a promising marker for leptospirosis-associated AKI 
      among the tested biomarkers. Thus, further validation is recommended with a 
      larger study group.
CI  - Copyright (c) 2021 Thilini Nisansala et al.
FAU - Nisansala, Thilini
AU  - Nisansala T
AUID- ORCID: 0000-0002-2194-6802
AD  - Department of Microbiology, Faculty of Medical Sciences, University of Sri 
      Jayewardenepura, Sri Lanka.
FAU - Weerasekera, Manjula
AU  - Weerasekera M
AUID- ORCID: 0000-0002-8194-2205
AD  - Department of Microbiology, Faculty of Medical Sciences, University of Sri 
      Jayewardenepura, Sri Lanka.
FAU - Ranasinghe, Nilantha
AU  - Ranasinghe N
AUID- ORCID: 0000-0002-8149-9928
AD  - Base Hospital, Panadura, Sri Lanka.
FAU - Marasinghe, Chamil
AU  - Marasinghe C
AUID- ORCID: 0000-0002-9499-6376
AD  - Department of Medicine, Faculty of Medical Sciences, University of Sri 
      Jayewardenepura, Sri Lanka.
FAU - Gamage, Chandika
AU  - Gamage C
AUID- ORCID: 0000-0003-0974-5730
AD  - Department of Microbiology, Faculty of Medicine, University of Peradeniya, Sri 
      Lanka.
FAU - Fernando, Neluka
AU  - Fernando N
AUID- ORCID: 0000-0001-7551-8224
AD  - Department of Microbiology, Faculty of Medical Sciences, University of Sri 
      Jayewardenepura, Sri Lanka.
FAU - Gunasekara, Chinthika
AU  - Gunasekara C
AUID- ORCID: 0000-0002-6003-3088
AD  - Department of Microbiology, Faculty of Medical Sciences, University of Sri 
      Jayewardenepura, Sri Lanka.
LA  - eng
PT  - Journal Article
DEP - 20210602
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (HAVCR1 protein, human)
RN  - 0 (Hepatitis A Virus Cellular Receptor 1)
SB  - IM
MH  - *Acute Kidney Injury/blood/diagnosis/etiology
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Hepatitis A Virus Cellular Receptor 1/*blood
MH  - Humans
MH  - *Leptospirosis/blood/complications/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Sri Lanka
PMC - PMC8192184
COIS- The authors declare that they have no conflicts of interests.
EDAT- 2021/06/15 06:00
MHDA- 2021/09/23 06:00
PMCR- 2021/06/02
CRDT- 2021/06/14 09:52
PHST- 2020/06/18 00:00 [received]
PHST- 2021/05/05 00:00 [revised]
PHST- 2021/05/22 00:00 [accepted]
PHST- 2021/06/14 09:52 [entrez]
PHST- 2021/06/15 06:00 [pubmed]
PHST- 2021/09/23 06:00 [medline]
PHST- 2021/06/02 00:00 [pmc-release]
AID - 10.1155/2021/1752904 [doi]
PST - epublish
SO  - Biomed Res Int. 2021 Jun 2;2021:1752904. doi: 10.1155/2021/1752904. eCollection 
      2021.