PMID- 34124478
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210615
IS  - 2470-1343 (Electronic)
IS  - 2470-1343 (Linking)
VI  - 6
IP  - 22
DP  - 2021 Jun 8
TI  - Antimicrobial PDMS Surfaces Prepared through Fast and Oxygen-Tolerant 
      SI-SARA-ATRP, Using Na(2)SO(3) as a Reducing Agent.
PG  - 14551-14558
LID - 10.1021/acsomega.1c01611 [doi]
AB  - Poly(dimethylsiloxane) (PDMS) is an attractive, versatile, and convenient 
      material for use in biomedical devices that are in direct contact with the user. 
      A crucial component in such a device is its surface in terms of antimicrobial 
      properties preventing infection. Moreover, due to its inherent hydrophobicity, 
      PDMS is rather prone to microbial colonization. Thus, developing an antimicrobial 
      PDMS surface in a simple, large-scale, and applicable manner is an essential step 
      in fully exploiting PDMS in the biomedical device industry. Current chemical 
      modification methods for PDMS surfaces are limited; therefore, we present herein 
      a new method for introducing an atom transfer radical polymerization (ATRP) 
      initiator onto the PDMS surface via the base-catalyzed grafting of 
      [(chloromethyl)phenylethyl]trimethoxysilane to the PDMS. The initiator surface 
      was grafted with poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) brushes via 
      a surface-initiated supplemental activator and reducing agent ATRP 
      (SI-SARA-ATRP). The use of sodium sulfite as a novel reducing agent in 
      SI-SARA-ATRP allowed for polymerization during complete exposure to air. 
      Moreover, a fast and linear growth was observed for the polymer over time, 
      leading to a 400 nm thick polymer layer in a 120 min reaction time. Furthermore, 
      the grafted PDMAEMA was quaternized, using various alkylhalides, in order to 
      study the effect on surface antimicrobial properties. It was shown that 
      antimicrobial activity not only depended highly on the charge density but also on 
      the amphiphilicity of the surface. The fast reaction rate, high oxygen tolerance, 
      increased antimicrobial activity, and the overall robustness and simplicity of 
      the presented method collectively move PDMS closer to its full-scale exploitation 
      in biomedical devices.
CI  - (c) 2021 The Authors. Published by American Chemical Society.
FAU - Andersen, Christian
AU  - Andersen C
AD  - Danish Polymer Centre, Department of Chemical and Biochemical Engineering, 
      Technical University of Denmark, Soltofts Plads Building 229, 2800 Kgs. Lyngby, 
      Denmark.
FAU - Zverina, Libor
AU  - Zverina L
AD  - Danish Polymer Centre, Department of Chemical and Biochemical Engineering, 
      Technical University of Denmark, Soltofts Plads Building 229, 2800 Kgs. Lyngby, 
      Denmark.
FAU - Ehtiati, Koosha
AU  - Ehtiati K
AD  - Department of Chemistry, Technical University of Denmark, Kemitorvet Building 
      207, 2800 Kgs. Lyngby, Denmark.
FAU - Thormann, Esben
AU  - Thormann E
AUID- ORCID: 0000-0002-2364-3493
AD  - Department of Chemistry, Technical University of Denmark, Kemitorvet Building 
      207, 2800 Kgs. Lyngby, Denmark.
FAU - Mordhorst, Hanne
AU  - Mordhorst H
AD  - National Food Institute, Technical University of Denmark, Kemitorvet, Building 
      202, 2800 Kgs. Lyngby, Denmark.
FAU - Pamp, Sunje J
AU  - Pamp SJ
AD  - National Food Institute, Technical University of Denmark, Kemitorvet, Building 
      202, 2800 Kgs. Lyngby, Denmark.
FAU - Madsen, Niels J
AU  - Madsen NJ
AD  - Coloplast A/S, Holtedam 1-3, 3050 Humlebaek, Denmark.
FAU - Daugaard, Anders E
AU  - Daugaard AE
AUID- ORCID: 0000-0002-0627-6310
AD  - Danish Polymer Centre, Department of Chemical and Biochemical Engineering, 
      Technical University of Denmark, Soltofts Plads Building 229, 2800 Kgs. Lyngby, 
      Denmark.
LA  - eng
PT  - Journal Article
DEP - 20210521
PL  - United States
TA  - ACS Omega
JT  - ACS omega
JID - 101691658
PMC - PMC8190881
COIS- The authors declare no competing financial interest.
EDAT- 2021/06/15 06:00
MHDA- 2021/06/15 06:01
PMCR- 2021/05/21
CRDT- 2021/06/14 09:55
PHST- 2021/03/25 00:00 [received]
PHST- 2021/05/07 00:00 [accepted]
PHST- 2021/06/14 09:55 [entrez]
PHST- 2021/06/15 06:00 [pubmed]
PHST- 2021/06/15 06:01 [medline]
PHST- 2021/05/21 00:00 [pmc-release]
AID - 10.1021/acsomega.1c01611 [doi]
PST - epublish
SO  - ACS Omega. 2021 May 21;6(22):14551-14558. doi: 10.1021/acsomega.1c01611. 
      eCollection 2021 Jun 8.