PMID- 34124961
OWN - NLM
STAT- MEDLINE
DCOM- 20220316
LR  - 20220502
IS  - 1477-0970 (Electronic)
IS  - 1352-4585 (Linking)
VI  - 28
IP  - 3
DP  - 2022 Mar
TI  - High antibody levels against human herpesvirus-6A interact with lifestyle factors 
      in multiple sclerosis development.
PG  - 383-392
LID - 10.1177/13524585211022011 [doi]
AB  - BACKGROUND: Infection with human herpesvirus 6A (HHV-6A) has been suggested to 
      increase multiple sclerosis (MS) risk. However, potential interactions between 
      HHV-6A and environmental/lifestyle risk factors for MS have not previously been 
      studied. METHODS: We used two Swedish population-based case-control studies 
      comprising 5993 cases and 5995 controls. Using logistic regression models, 
      subjects with different HHV-6A antibody levels, environmental exposures, and 
      lifestyle habits were compared regarding MS risk, by calculating odds ratios 
      (ORs) with 95% confidence intervals (CIs). Potential interactions between high 
      HHV-6A antibody levels and common environmental exposures and lifestyle factors 
      were evaluated on the additive scale. RESULTS: High HHV-6A antibody levels were 
      associated with increased risk of developing MS (OR = 1.5, 95% CI = 1.4-1.6). 
      Regarding MS risk, significant interactions were observed between high HHV-6A 
      antibody levels and both smoking (attributable proportion (AP) = 0.2, 95% 
      CI = 0.1-0.3), low ultraviolet radiation (UVR) exposure (AP = 0.3, 95% 
      CI = 0.1-0.4), and low vitamin D levels (AP = 0.3, 95% CI = 0.0-0.6). CONCLUSION: 
      High HHV-6A antibody levels are associated with increased MS risk and act 
      synergistically with common environmental/lifestyle risk factors for MS. Further 
      research is needed to investigate potential mechanisms underlying the 
      interactions presented in this study.
FAU - Wu, Jing
AU  - Wu J
AUID- ORCID: 0000-0002-6033-3734
AD  - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 
      Sweden/Aging Research Center, Department of Neurobiology, Care Sciences and 
      Society, Karolinska Institutet, Stockholm, Sweden.
FAU - Engdahl, Elin
AU  - Engdahl E
AD  - Department of Clinical Neuroscience and Center for Molecular Medicine, Karolinska 
      Institutet, Stockholm, Sweden.
FAU - Gustafsson, Rasmus
AU  - Gustafsson R
AD  - Department of Clinical Neuroscience and Center for Molecular Medicine, Karolinska 
      Institutet, Stockholm, Sweden.
FAU - Fogdell-Hahn, Anna
AU  - Fogdell-Hahn A
AD  - Department of Clinical Neuroscience and Center for Molecular Medicine, Karolinska 
      Institutet, Stockholm, Sweden.
FAU - Waterboer, Tim
AU  - Waterboer T
AD  - German Cancer Research Center (DKFZ), Heidelberg, Germany.
FAU - Hillert, Jan
AU  - Hillert J
AD  - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, 
      Sweden/Department of Research and Education, Karolinska University Hospital, 
      Sweden.
FAU - Olsson, Tomas
AU  - Olsson T
AD  - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
FAU - Alfredsson, Lars
AU  - Alfredsson L
AD  - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
FAU - Hedstrom, Anna Karin
AU  - Hedstrom AK
AUID- ORCID: 0000-0002-6612-4749
AD  - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210614
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
SB  - IM
MH  - Case-Control Studies
MH  - *Herpesvirus 6, Human
MH  - Humans
MH  - Life Style
MH  - *Multiple Sclerosis
MH  - Ultraviolet Rays
OTO - NOTNLM
OT  - *Multiple sclerosis
OT  - *environmental risk factors
OT  - *human herpesvirus 6A
OT  - *interaction
EDAT- 2021/06/15 06:00
MHDA- 2022/03/17 06:00
CRDT- 2021/06/14 12:19
PHST- 2021/06/15 06:00 [pubmed]
PHST- 2022/03/17 06:00 [medline]
PHST- 2021/06/14 12:19 [entrez]
AID - 10.1177/13524585211022011 [doi]
PST - ppublish
SO  - Mult Scler. 2022 Mar;28(3):383-392. doi: 10.1177/13524585211022011. Epub 2021 Jun 
      14.