PMID- 34125323
OWN - NLM
STAT- MEDLINE
DCOM- 20220127
LR  - 20220422
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Print)
IS  - 1590-1874 (Linking)
VI  - 43
IP  - 2
DP  - 2022 Feb
TI  - Clinical significance of self-descriptive apathy assessment in patients with 
      neurological form of Wilson's disease.
PG  - 1385-1394
LID - 10.1007/s10072-021-05366-0 [doi]
AB  - BACKGROUND AND AIM: Apathy is one of the neuropsychiatric symptoms of Wilson's 
      disease (WD) which typically affects the brain's fronto-basal circuits. Lack of 
      agreed diagnostic criteria and common use of self-description assessment tools 
      lead to underestimation of this clinical phenomenon. The aim of this study was to 
      investigate whether subjective and informant-based clinical features of apathy in 
      patients with WD enable clinicians to make a valid diagnosis. METHODS: Multiple 
      aspects of goal-oriented behavior were assessed in 30 patients with the 
      neurological form of WD and 30 age-matched healthy participants using two 
      questionnaires, the Lille Apathy Rating Scale (LARS) and the Dysexecutive 
      Questionnaire (DEX). Both included a self-descriptive and a caregiver/proxy 
      version. Cognitive functioning was estimated with the use of Addenbrooke's 
      Cognitive Examination-Revised. RESULTS: Patients obtained significantly worse 
      scores on all clinical scales when more objective measures were considered. 
      Features of apathy and executive dysfunction were revealed in patients' caregiver 
      versions of LARS and DEX, which may indicate poor self-awareness of patients with 
      WD. Roughly 30% of participants were likely to present with clinically meaningful 
      symptoms, independent of cognitive dysfunction. CONCLUSIONS: Methods relying on 
      self-description appear inferior to informant-based scales when diagnosing 
      apathy. More objective criteria and measurement tools are needed to better 
      understand this clinical syndrome.
CI  - (c) 2021. The Author(s).
FAU - Lesniak, Marcin
AU  - Lesniak M
AD  - Faculty of Psychology, University of Warsaw, Warsaw, Poland.
FAU - Roessler-Gorecka, Magdalena
AU  - Roessler-Gorecka M
AD  - Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957, Warsaw, Poland.
FAU - Czlonkowska, Anna
AU  - Czlonkowska A
AD  - Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957, Warsaw, Poland.
FAU - Seniow, Joanna
AU  - Seniow J
AUID- ORCID: 0000-0002-1017-4819
AD  - Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957, Warsaw, Poland. 
      seniowj@ipin.edu.pl.
LA  - eng
GR  - 501-15-021-20016/Institute of Psychiatry and Neurology/
GR  - 501-D125-01-1250000 zlec*. 5011000206/Ministerstwo Nauki i Szkolnictwa Wyzszego/
PT  - Journal Article
DEP - 20210614
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
SB  - IM
MH  - *Apathy
MH  - Caregivers
MH  - Cognition
MH  - *Cognitive Dysfunction/diagnosis/etiology
MH  - *Hepatolenticular Degeneration/diagnosis
MH  - Humans
PMC - PMC8789726
OTO - NOTNLM
OT  - Apathy syndrome
OT  - Cognitive impairment
OT  - Psychopathology
OT  - Self-description
OT  - Wilson's disease
COIS- The authors declare no competing interests.
EDAT- 2021/06/15 06:00
MHDA- 2022/01/28 06:00
PMCR- 2021/06/14
CRDT- 2021/06/14 12:38
PHST- 2021/02/15 00:00 [received]
PHST- 2021/05/29 00:00 [accepted]
PHST- 2021/06/15 06:00 [pubmed]
PHST- 2022/01/28 06:00 [medline]
PHST- 2021/06/14 12:38 [entrez]
PHST- 2021/06/14 00:00 [pmc-release]
AID - 10.1007/s10072-021-05366-0 [pii]
AID - 5366 [pii]
AID - 10.1007/s10072-021-05366-0 [doi]
PST - ppublish
SO  - Neurol Sci. 2022 Feb;43(2):1385-1394. doi: 10.1007/s10072-021-05366-0. Epub 2021 
      Jun 14.