PMID- 34126225
OWN - NLM
STAT- MEDLINE
DCOM- 20210816
LR  - 20210816
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 152
DP  - 2021 Sep
TI  - Regular physical activity reduces the proinflammatory response in older women 
      with diabetes and hypertension in the postmenopausal phase.
PG  - 111449
LID - S0531-5565(21)00231-X [pii]
LID - 10.1016/j.exger.2021.111449 [doi]
AB  - Aging in women is characterized by extreme hormonal changes leading them to 
      develop a chronic low-grade inflammation that is linked to the development of 
      systemic arterial hypertension (SAH) and type 2 diabetes mellitus (T2DM). In this 
      scenario, physical activity emerges as an interesting methodology, since it seems 
      to be connected to a decrease in serum levels of some pro-inflammatory cytokines. 
      Nevertheless, most studies evaluate these cytokines in an isolated manner not 
      considering the influence of comorbidities on the responsiveness of participants 
      to the benefits of physical activity. So, this study aimed to assess the 
      influence of physical activity on body composition, anthropometric parameters, 
      lipid profile, and inflammatory markers of diabetic and hypertensive older 
      postmenopausal women. We evaluated 163 women aged from 60 to 80 years, diagnosed 
      with T2DM and SAH that were assisted by the Family Health Units in Vitoria da 
      Conquista, Bahia, Brazil. The pratice of physical activity was measured by the 
      International Physical Activity Questionnaire with the participants being 
      classified as active or sedentary individuals. Active older women presented 
      better body composition, lipid profile and inflammatory balance. This was 
      connected to a better correlation profile between these factors in active older 
      women, characteristics that were not noticed in sedentary older women. Moreover, 
      IL-17A and the relationship between IL-10 and the other pro-inflammatory 
      cytokines examined was greatly influenced by physical activity. Consequently, 
      physical activity is linked to a global improvement in T2DM and SAH risk factors 
      and with a positive inflammatory modulation in diabetic and hypertensive older 
      women.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Lopes, Diego P S
AU  - Lopes DPS
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Hormindo Barros Street, 17 Block, 58 Lot, Candeias, 45.029-094 
      Vitoria da Conquista, Bahia, Brazil.
FAU - Ribeiro, Israel S
AU  - Ribeiro IS
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Hormindo Barros Street, 17 Block, 58 Lot, Candeias, 45.029-094 
      Vitoria da Conquista, Bahia, Brazil; Paulo Freire Campus, Federal University of 
      Southern Bahia, 250 Joana Angelica Square, Sao Jose, 45.988-058 Teixeira de 
      Freitas, Bahia, Brazil.
FAU - Santos, Deborah C
AU  - Santos DC
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Hormindo Barros Street, 17 Block, 58 Lot, Candeias, 45.029-094 
      Vitoria da Conquista, Bahia, Brazil.
FAU - Lima, Fernanda M S
AU  - Lima FMS
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Hormindo Barros Street, 17 Block, 58 Lot, Candeias, 45.029-094 
      Vitoria da Conquista, Bahia, Brazil.
FAU - Santos, Andressa A
AU  - Santos AA
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Hormindo Barros Street, 17 Block, 58 Lot, Candeias, 45.029-094 
      Vitoria da Conquista, Bahia, Brazil.
FAU - Souza, Daniela S P
AU  - Souza DSP
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Hormindo Barros Street, 17 Block, 58 Lot, Candeias, 45.029-094 
      Vitoria da Conquista, Bahia, Brazil.
FAU - Lopes, Danilo N
AU  - Lopes DN
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Hormindo Barros Street, 17 Block, 58 Lot, Candeias, 45.029-094 
      Vitoria da Conquista, Bahia, Brazil.
FAU - Prado, Alice O
AU  - Prado AO
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Hormindo Barros Street, 17 Block, 58 Lot, Candeias, 45.029-094 
      Vitoria da Conquista, Bahia, Brazil.
FAU - Pereira, Italo S
AU  - Pereira IS
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Hormindo Barros Street, 17 Block, 58 Lot, Candeias, 45.029-094 
      Vitoria da Conquista, Bahia, Brazil.
FAU - Santos, Denisar P
AU  - Santos DP
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Hormindo Barros Street, 17 Block, 58 Lot, Candeias, 45.029-094 
      Vitoria da Conquista, Bahia, Brazil; FG Universitary Center, UniFG, 459 Barao do 
      Rio Branco Avenue, Downtown, 46430-000 Guanambi, Bahia, Brazil.
FAU - Santos, Gilvaneia S
AU  - Santos GS
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Hormindo Barros Street, 17 Block, 58 Lot, Candeias, 45.029-094 
      Vitoria da Conquista, Bahia, Brazil.
FAU - Silva, Robson A A
AU  - Silva RAA
AD  - Multidisciplinary Institute of Health, Anisio Teixeira Campus, Federal University 
      of Bahia, 58 Hormindo Barros Street, 17 Block, 58 Lot, Candeias, 45.029-094 
      Vitoria da Conquista, Bahia, Brazil. Electronic address: ramaro@ufba.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210611
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
SB  - IM
MH  - Aged
MH  - Body Composition
MH  - *Diabetes Mellitus, Type 2
MH  - Exercise
MH  - Female
MH  - Humans
MH  - *Hypertension
MH  - Postmenopause
OTO - NOTNLM
OT  - Inflammaging
OT  - Older women
OT  - Physical activity
OT  - Postmenopause
OT  - Systemic arterial hypertension
OT  - Type 2 diabetes mellitus
EDAT- 2021/06/15 06:00
MHDA- 2021/08/17 06:00
CRDT- 2021/06/14 20:15
PHST- 2020/09/01 00:00 [received]
PHST- 2021/06/06 00:00 [revised]
PHST- 2021/06/08 00:00 [accepted]
PHST- 2021/06/15 06:00 [pubmed]
PHST- 2021/08/17 06:00 [medline]
PHST- 2021/06/14 20:15 [entrez]
AID - S0531-5565(21)00231-X [pii]
AID - 10.1016/j.exger.2021.111449 [doi]
PST - ppublish
SO  - Exp Gerontol. 2021 Sep;152:111449. doi: 10.1016/j.exger.2021.111449. Epub 2021 
      Jun 11.